GSE262759 Shared Transcriptomic Signatures of Inflammaging Among Diverse Strains of Drosophila melanogaster

Contributors : Sabrina I Perna ; Weihao Tang ; Andrew Li ; Sydney D Blimbaum ; Lei ZhouSeries Type : Expression profiling by high throughput sequencingOrganism : Drosophila melanogasterBackground: A prominent hallmark of aging is inflammaging —the increased expression of innate immune genes without identifiable infection. Model organisms with shorter lifespans, such as the fruit fly, provide an essential platform for probing the mechanisms of inflammaging. Multiple groups have reported that, like mammalian models, old flies have signif icantly higher levels of expression of anti-microbial peptide genes. However, whether some of these genes—or any others—can serve as reliable markers for assessing and comparing inflammaging in different strains remains unclear. Methods and Results: We compared RNA-Seq datasets generated by diff erent groups. Although the fly strains used in these studies differ significantly, we found that they share a core group of genes with strong aging-associated expression. In addition to anti-microbial peptide genes, we identified other genes that have prominently increased expression in old flies, e specially SPH93. We further showed that machine learning models can be used to predict the “inflammatory age” of the fruit fly.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Drosophila melanogaster Source Type: research