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Effects of TrPLDs on the pathogenicity of Trichothecium roseum infected apple fruit
Food Microbiol. 2024 Aug;121:104496. doi: 10.1016/j.fm.2024.104496. Epub 2024 Feb 23.ABSTRACTPhospholipase D plays a critical regulatory role in the pathogenicity of filamentous fungi. However, the molecular mechanism of PLD regulating the pathogenicity of filamentous fungi has not been reported. In this research, the previously constructed TrPLD1 and TrPLD2 (TrPLDs) mutants were used as test strains. Firstly, the function of TrPLDs in Trichothecium roseum was studied. Then, the effects of TrPLDs on the pathogenicity of T. roseum and the quality of the inoculated apples were verified. The results suggested that the deletio...
Source: Food Microbiology - April 18, 2024 Category: Food Science Authors: Qili Liu Qianqian Zhang Huali Xue Yang Bi Xi Yang Yuanyuan Zong Zhiguang Liu Prusky Dov Source Type: research

A Long-Lived Alpine Perennial Advances Flowering under Warmer Conditions but Not Enough to Maintain Reproductive Success
Am Nat. 2024 May;203(5):E157-E174. doi: 10.1086/729438. Epub 2024 Mar 27.ABSTRACTAbstractAssessing whether phenological shifts in response to climate change confer a fitness advantage requires investigating the relationships among phenology, fitness, and environmental drivers of selection. Despite widely documented advancements in phenology with warming climate, we lack empirical estimates of how selection on phenology varies in response to continuous climate drivers or how phenological shifts in response to warming conditions affect fitness. We leverage an unusual long-term dataset with repeated, individual measurements o...
Source: The American Naturalist - April 18, 2024 Category: Biology Authors: Meredith A Zettlemoyer Rebecca J Conner Micaela M Seaver Ellen Waddle Megan L DeMarche Source Type: research

Highlights from the literature
Fruit juice – good for you? Child or adult, drinking fruit juice must be a great way of contributing to your five-a-day of fruits and vegetables. There is a lot of free sugar in 100% fruit juice and no fibre. Do these high sugar drinks contribute to obesity? Nguyen M et al (JAMA Pediatr 2024;178:237–246) have completed a systematic review focussing on the evidence that fruit juice has an impact on weight gain and BMI by examining MEDLINE, Embase, and Cochrane databases searching up to 18 May 2023. They looked for prospective cohort studies of at least 6 months and randomised clinical trials (RCTs) of at least 2...
Source: Archives of Disease in Childhood - April 18, 2024 Category: Pediatrics Tags: Miscellanea Source Type: research

The SARM1 TIR domain produces glycocyclic ADPR molecules as minor products
In this study we show that the TIR domains of both human and fruit fly SARM1 produce 1 ′′–2′ and 1′′–3′ glycocyclic ADP-ribose (gcADPR) molecules as minor products. As previously reported, we observed that SARM1 TIR domains mostly convert NAD+ to ADPR (for human SARM1) or cADPR (in the case of SARM1 fromDrosophila melanogaster). However, we now show that human andDrosophila SARM1 additionally convert ~0.1 –0.5% of NAD+ into gcADPR molecules. We find that SARM1 TIR domains produce gcADPR molecules both when purifiedin vitro and when expressed in bacterial cells. Given that gcADPR is a second messenger invo...
Source: PLoS One - April 18, 2024 Category: Biomedical Science Authors: Jeremy Garb Source Type: research

Unveiling the Molecular Mechanism of Diosmetin and its Impact on Multifaceted Cellular Signaling Pathways
CONCLUSION: The amalgamation of the review underscores diosmetin's promising role as a multifaceted therapeutic agent, highlighting its potential for drug development and clinical applications.PMID:38629379 | DOI:10.2174/0109298665294109240323033601 (Source: Protein and Peptide Letters)
Source: Protein and Peptide Letters - April 17, 2024 Category: Biochemistry Authors: Krishna Kumar Varshney Jeetendra Kumar Gupta Rajnish Srivastava Source Type: research

Cyclopeptide alkaloids from the Greek shrub Paliurus spina - christi and their in silico binding affinity to Dipeptidyl Peptidase IV
Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and ar...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Vaios Amountzias Dennis Abatis Antonios Drakopoulos Grigoris Zoidis Nektarios Aligiannis Source Type: research

Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Cell Research)
Source: Cell Research - April 17, 2024 Category: Cytology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research

Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Atherosclerosis)
Source: Atherosclerosis - April 17, 2024 Category: Cardiology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research

Extract of Gualou-Xiebai Herb Pair Improves Lipid Metabolism Disorders by Enhancing the Reverse Cholesterol Transport in Atherosclerosis Mice
CONCLUSION: In summary, our results suggested that GXE improved lipid metabolism disorders by enhancing RCT, providing a scientific basis for the clinical use of GXE in AS treatment.PMID:38629368 | DOI:10.2174/0115672026308438240405055719 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - April 17, 2024 Category: Neurology Authors: Yarong Liu Tian Wang Lidan Ding Zhenglong Li Yexiang Zhang Min Dai Hongfei Wu Source Type: research