Cyclopeptide alkaloids from the Greek shrub < em > Paliurus spina < /em > - < em > christi < /em > and their < em > in silico < /em > binding affinity to Dipeptidyl Peptidase IV

Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and are predicted to exhibit significant affinity to DPP4, in the range of low 2-digit μΜ.PMID:38629156 | DOI:10.1080/14786419.2024.2340755
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research