Brusatol hinders the progression of bladder cancer by Chac1/Nrf2/SLC7A11 pathway
Exp Cell Res. 2024 Apr 24;438(2):114053. doi: 10.1016/j.yexcr.2024.114053. Online ahead of print.ABSTRACTBladder cancer is a common tumor that impacts the urinary system and marked by a significant fatality rate and an unfavorable prognosis. Promising antineoplastic properties are exhibited by brusatol, which is obtained from the dried ripe fruit of Brucea javanica. The present study aimed to evaluate the influence of brusatol on the progression of bladder cancer and uncover the molecular mechanism involved. We used Cell Counting Kit-8, colony formation and EdU assays to detect cell numbers, viability and proliferation. We...
Source: Experimental Cell Research - April 25, 2024 Category: Cytology Authors: X I Yu Ziqi He Qinghua Wang Shuai Ke Huaxin Wang Zhong Wang Shenglan Li Source Type: research
The Impact of the COVID-19 Pandemic on Food Access: Insights from First-Person Accounts in a Safety-Net Health Care System
J Health Care Poor Underserved. 2024;35(1):37-54.ABSTRACTThe COVID-19 pandemic disproportionately affected populations that were already facing socioeconomic disadvantages and limited access to health care services. The livelihood of millions was further compromised when strict shelter-in-place measures forced them out of their jobs. The way that individuals accessed food during the early stages of the COVID-19 pandemic drastically changed as a result of declines in household income, food chain supply disruptions, and social distance measures. This qualitative study examined the food access experiences of participants enro...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Dharma E Cort és Rachel M Zack Varshini Odayar Margo Moyer Anika Kumar Juliana Libardi Maia Jackie V Rodriguez Bronico Jean Granick Source Type: research
Obesity-Preventive Behaviors and Improvements in Depression among Diverse Utah Women Receiving Coaching from Community Health Workers
CONCLUSION: These results indicate value in addressing and evaluating depression in obesity-related interventions in underserved communities.PMID:38661866 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Grant R Sunada Kathleen B Digre Louisa A Stark France Davis Valentine Mukundente Eruera Napia Ana Sanchez-Birkhead O Fahina Tavake-Pasi Heather Brown Stephen C Alder Karen Gieseker Nan Hu Yelena Wu Sara E Simonsen Source Type: research
The Impact of the COVID-19 Pandemic on Food Access: Insights from First-Person Accounts in a Safety-Net Health Care System
J Health Care Poor Underserved. 2024;35(1):37-54.ABSTRACTThe COVID-19 pandemic disproportionately affected populations that were already facing socioeconomic disadvantages and limited access to health care services. The livelihood of millions was further compromised when strict shelter-in-place measures forced them out of their jobs. The way that individuals accessed food during the early stages of the COVID-19 pandemic drastically changed as a result of declines in household income, food chain supply disruptions, and social distance measures. This qualitative study examined the food access experiences of participants enro...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Dharma E Cort és Rachel M Zack Varshini Odayar Margo Moyer Anika Kumar Juliana Libardi Maia Jackie V Rodriguez Bronico Jean Granick Source Type: research
Obesity-Preventive Behaviors and Improvements in Depression among Diverse Utah Women Receiving Coaching from Community Health Workers
CONCLUSION: These results indicate value in addressing and evaluating depression in obesity-related interventions in underserved communities.PMID:38661866 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Grant R Sunada Kathleen B Digre Louisa A Stark France Davis Valentine Mukundente Eruera Napia Ana Sanchez-Birkhead O Fahina Tavake-Pasi Heather Brown Stephen C Alder Karen Gieseker Nan Hu Yelena Wu Sara E Simonsen Source Type: research
The Impact of the COVID-19 Pandemic on Food Access: Insights from First-Person Accounts in a Safety-Net Health Care System
J Health Care Poor Underserved. 2024;35(1):37-54.ABSTRACTThe COVID-19 pandemic disproportionately affected populations that were already facing socioeconomic disadvantages and limited access to health care services. The livelihood of millions was further compromised when strict shelter-in-place measures forced them out of their jobs. The way that individuals accessed food during the early stages of the COVID-19 pandemic drastically changed as a result of declines in household income, food chain supply disruptions, and social distance measures. This qualitative study examined the food access experiences of participants enro...
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Dharma E Cort és Rachel M Zack Varshini Odayar Margo Moyer Anika Kumar Juliana Libardi Maia Jackie V Rodriguez Bronico Jean Granick Source Type: research
Obesity-Preventive Behaviors and Improvements in Depression among Diverse Utah Women Receiving Coaching from Community Health Workers
CONCLUSION: These results indicate value in addressing and evaluating depression in obesity-related interventions in underserved communities.PMID:38661866 (Source: Journal of Health Care for the Poor and Underserved)
Source: Journal of Health Care for the Poor and Underserved - April 25, 2024 Category: International Medicine & Public Health Authors: Grant R Sunada Kathleen B Digre Louisa A Stark France Davis Valentine Mukundente Eruera Napia Ana Sanchez-Birkhead O Fahina Tavake-Pasi Heather Brown Stephen C Alder Karen Gieseker Nan Hu Yelena Wu Sara E Simonsen Source Type: research
Ameliorative effect of bofutsushosan (Fangfengtongshengsan) extract on the progression of aging-induced obesity
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obesity-reducing effects of a Kampo medicine, bofutsushosan (BTS; fangfengtongshengsan in Chinese). Aged mice fed a high-fat diet containing 2% BTS extract for 28 days exhibited a significant reduction in weight gain and accumulation of visceral and subcutaneous fat, which were greater degree of reduction than those of the young mice. When the treatment period was extended to two months, the serum aspartate aminotransferase and alanine aminotransferase leve ls and the accumulation of fat droplets in the h...
Source: Journal of Natural Medicines - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice
AbstractFibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy. Diosmetin, an aglycone of the flavonoid glycoside diosmin found in citrus fruits and the leaves ofOleaeuropaea L., has antinociceptive, anti-inflammatory, and antioxidant properties. Here, we investigated the effect of diosmetin on nociceptive behaviors and comorbidities in an experimental fibromyalgia model induced by reserpine in mice. To induce the experime...
Source: Inflammopharmacology - April 25, 2024 Category: Drugs & Pharmacology Source Type: research
Noni enhances the anticancer activity of cyclophosphamide and suppresses myelotoxicity and hepatotoxicity in tumor-bearing mice
ConclusionsThe present study suggested that CYL treatment can cause serious myelotoxicity and hepatic injury in cancer patients. In conclusion, the combined use of noni with CYL potentially enhances the antitumor activity of CYL and suppresses myelotoxicity and hepatotoxicity induced by CYL in tumor-bearing mice. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - April 25, 2024 Category: Cancer & Oncology Source Type: research
Sinapic Acid Mitigates Pentylenetetrazol-induced Acute Seizures By Modulating the NLRP3 Inflammasome and Regulating Calcium/calcineurin Signaling: In Vivo and In Silico Approaches
AbstractSinapic acid (SA) is a naturally occurring carboxylic acid found in citrus fruits and cereals. Recent studies have shown that SA has potential anti-seizure properties due to its anti-inflammatory, antioxidant, and anti-apoptotic effects. The present study investigated the neuroprotective role of SA at two different dosages in a pentylenetetrazol (PTZ)-induced acute seizure model. Mice were divided into six groups: normal control, PTZ, SA (20 mg/kg), SA (20 mg/kg) + PTZ, SA (40 mg/kg), and SA (40 mg/kg) + PTZ. SA was orally administered for 21 days, followed by a convulsive dose of intraperitoneal PTZ ...
Source: Inflammation - April 25, 2024 Category: Allergy & Immunology Source Type: research
Genomic characterization and probiotic potential assessment of an exopolysaccharide-producing strain Pediococcus pentosaceus LL-07 isolated from fermented meat
The genomic information available for Pediococcus pentosaceus is primarily derived from fermented fruits and vegetables, with less information available from fermented meat. P. pentosaceus LL-07, a strain isolate... (Source: BMC Microbiology)
Source: BMC Microbiology - April 25, 2024 Category: Microbiology Authors: Kuan Lu, Xueya Wang, Ying Zhou and Qiujin Zhu Tags: Research Source Type: research
Integrated metabolome and transcriptome analyses reveal the role of BoGSTF12 in anthocyanin accumulation in Chinese kale (Brassica oleracea var. alboglabra)
The vivid red, purple, and blue hues that are observed in a variety of plant fruits, flowers, and leaves are produced by anthocyanins, which are naturally occurring pigments produced by a series of biochemical... (Source: BMC Plant Biology)
Source: BMC Plant Biology - April 25, 2024 Category: Biology Authors: Kang Tang, Umer Karamat, Guihua Li, Juxian Guo, Shizheng Jiang, Mei Fu and Xian Yang Tags: Research Source Type: research
Implementation of Food is Medicine Programs in Healthcare Settings: A Narrative Review
AbstractFood is Medicine (FIM) programs to improve the accessibility of fruits and vegetables (FVs) or other healthy foods among patients with low income and diet-related chronic diseases are promising to improve food and nutrition security in the United States (US). However, FIM programs are relatively new and implementation guidance for healthcare settings using an implementation science lens is lacking. We used a narrative review to describe the evidence base on barriers and facilitators to FIM program integration in US healthcare settings following the Exploration, Preparation, Implementation, and Sustainment (EPIS) Fr...
Source: Journal of General Internal Medicine - April 25, 2024 Category: Internal Medicine Source Type: research
Sinapic Acid Mitigates Pentylenetetrazol-induced Acute Seizures By Modulating the NLRP3 Inflammasome and Regulating Calcium/calcineurin Signaling: In Vivo and In Silico Approaches
AbstractSinapic acid (SA) is a naturally occurring carboxylic acid found in citrus fruits and cereals. Recent studies have shown that SA has potential anti-seizure properties due to its anti-inflammatory, antioxidant, and anti-apoptotic effects. The present study investigated the neuroprotective role of SA at two different dosages in a pentylenetetrazol (PTZ)-induced acute seizure model. Mice were divided into six groups: normal control, PTZ, SA (20 mg/kg), SA (20 mg/kg) + PTZ, SA (40 mg/kg), and SA (40 mg/kg) + PTZ. SA was orally administered for 21 days, followed by a convulsive dose of intraperitoneal PTZ ...
Source: Inflammation - April 25, 2024 Category: Allergy & Immunology Source Type: research
