Metabolic activation and cytochrome P450 inhibition of piperlonguminine mediated by CYP3A4

This study characterized the O-dealkylated metabolite (M1) through chemical synthesis. The IC50 shift assay showed time-dependent inhibition of CYP3A4, 2C9, 2E1, 2C8 and 2D6 by PLG. This research contributes to the understanding of PLG-induced enzyme inhibition and bioactivation.PMID:38626834 | DOI:10.1016/j.ijbiomac.2024.131502

Source: International Journal of Biological Macromolecules - April 16, 2024 Category: Biochemistry Authors: Yuqian Chi Xiaoliang Zhu Yaxuan Chen Xin Li Ziyi Jiang Xiaoyang Jian Mengyuan Lian Xiaodi Wu Lei Wang Mengmeng Sun Xiaowei Shi Source Type: research