Hesperidin activates Nrf2 to protect cochlear hair cells from cisplatin-induced damage

This study employs both in vivo and in vitro models of cisplatin ototoxicity to explore this possibility. Our results reveal that hesperidin mitigates cisplatin-induced ototoxicity by activating the Nrf2/NQO1 pathway in sensory hair cells, thereby reducing ROS accumulation, preventing hair cell apoptosis, and alleviating hearing loss.PMID:38629504 | DOI:10.1080/13510002.2024.2341470
Source: Redox Report : communications in free radical research - Category: Biochemistry Authors: Source Type: research