In vitro characterization and molecular epidemiology of Cryptococcus spp. isolates from non-HIV patients in Guangdong, China
ConclusionPhenotypically variant and non-wild-type strains were found in Guangdong, and a significant proportion of these strains had MIC values near the ECV values towards the 6 antifungal drugs, and resistance was observed for 4 out of 6 drugs. The molecular type was highly homogeneous but compositionally diverse, with rare types found. Enhanced surveillance of the aetiology and evolution and continuous monitoring of antifungal susceptibility are needed to provide references for decision-making in the health sector and optimization of disease prevention and control. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - January 15, 2024 Category: Microbiology Source Type: research
Low ‐dose fluconazole as a useful and safe prophylactic option in patients receiving allogeneic hematopoietic stem cell transplantation
ConclusionLow-dose FLCZ prophylaxis is a useful and safe option for patients receiving allogeneic HSCT, except in those undergoing CBT or having any fungal risk features including history of fungal infections, positive fungal markers, and abnormal findings on lung CT before transplantation. (Source: Cancer Medicine)
Source: Cancer Medicine - January 12, 2024 Category: Cancer & Oncology Authors: Kentaro Hirade,
Shigeru Kusumoto,
Hiroya Hashimoto,
Kazuhide Shiraga,
Shinya Hagiwara,
Kana Oiwa,
Tomotaka Suzuki,
Shiori Kinoshita,
Masaki Ri,
Hirokazu Komatsu,
Shinsuke Iida Tags: RESEARCH ARTICLE Source Type: research
EXPLORING THE FLUCONAZOLE-RESISTANCE MODIFYING ACTIVITY AND POTENTIAL MECHANISM OF ACTION OF FIXED OIL FROM Caryocar coriaceum WITTM. (CARYOCARACEAE) AGAINST Candida SPECIES
This study aimed to evaluate the chemical composition, antifungal activity, reduction of fungal virulence, and toxicity of the fixed oil from the inner mesocarp of C. coriaceum tested against three Candida yeasts. The oil was characterized by gas chromatography (GC-MS and GC-FID). Antifungal activity was assessed using the serial microdilution method. Additionally, the potential of the oil as an enhancer of fluconazole action was tested at sub-inhibitory concentrations (MIC/8). The mechanisms of action of the fixed oil of C. coriaceum on the morphological transition of Candida spp. strains and their virulence factors. The ...
Source: Chemistry and Biodiversity - January 10, 2024 Category: Biochemistry Authors: Jos é Almeida-Bezerra Rafael Cruz Viviane Silva Jo ão Silva Neto Larissa Souza Daniele Sousa Nadine Araujo Rafael Silva Blasco Quefi Martinho Rau Ricardo Rebelo Sarah Santos Luiz Silva Henrique Coutinho Saulo Menezes Maria Flaviana Morais-Braga Antonio Source Type: research
Case Report: A Series of Three Meningoencephalitis Cases Caused by Acanthamoeba spp. from Eastern India
We present three cases of Acanthamoeba meningoencephalitis in immunocompetent individuals from Eastern India. The first patient presented with fever and headache; the second with headache, visual disturbance, and squint; and the third presented in a drowsy state. The cases presented on March 3, 18, and 21, 2023 respectively. The first two patients had concomitant tubercular meningitis for which they received antitubercular therapy and steroid. Their cerebrospinal fluid showed slight lymphocytic pleocytosis and increased protein. The diagnosis was done by microscopy, culture, and polymerase chain reaction. They received a c...
Source: Am J Trop Med Hyg - January 8, 2024 Category: Infectious Diseases Authors: Soumendra Nath Haldar Kokila Banerjee Dolanchampa Modak Agnibho Mondal Chayan Sharma Teja Vasireddy Rucha Kalyan Karad Hardik Bharatbhai Patel Debajyoti Majumdar Boudhayan Bhattacharjee Sumeeta Khurana Tapashi Ghosh Subhasish Kamal Guha Bibhuti Saha Source Type: research
Case Report: A Series of Three Meningoencephalitis Cases Caused by Acanthamoeba spp. from Eastern India
We present three cases of Acanthamoeba meningoencephalitis in immunocompetent individuals from Eastern India. The first patient presented with fever and headache; the second with headache, visual disturbance, and squint; and the third presented in a drowsy state. The cases presented on March 3, 18, and 21, 2023 respectively. The first two patients had concomitant tubercular meningitis for which they received antitubercular therapy and steroid. Their cerebrospinal fluid showed slight lymphocytic pleocytosis and increased protein. The diagnosis was done by microscopy, culture, and polymerase chain reaction. They received a c...
Source: The American Journal of Tropical Medicine and Hygiene - January 8, 2024 Category: Tropical Medicine Authors: Soumendra Nath Haldar Kokila Banerjee Dolanchampa Modak Agnibho Mondal Chayan Sharma Teja Vasireddy Rucha Kalyan Karad Hardik Bharatbhai Patel Debajyoti Majumdar Boudhayan Bhattacharjee Sumeeta Khurana Tapashi Ghosh Subhasish Kamal Guha Bibhuti Saha Source Type: research
A single-blind randomised study comparing the efficacy of fluconazole and itraconazole for the treatment of Malassezia dermatitis in client-owned dogs
CONCLUSIONS AND CLINICAL RELEVANCE: This study indicates that 5FZ and 10FZ are as effective as itraconazole in canine Malassezia dermatitis.PMID:38169074 | DOI:10.1111/vde.13233 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - January 3, 2024 Category: Veterinary Research Authors: Hayoon Lee Yoonhoi Koo Taesik Yun Dohee Lee Yeon Chae Kyung-Duk Min Hakhyun Kim Mhan-Pyo Yang Byeong-Teck Kang Source Type: research
Prediction of drug-drug interactions between roflumilast and CYP3A4/1A2 perpetrators using a physiologically-based pharmacokinetic (PBPK) approach
This study aimed to develop a physiologically-based pharmacokinetic (PBPK) model to predict changes in the pharmacokinetics (PK) and pharmacodynamics (PD, PDE4 inhibition) of roflumilast (ROF) and ROF N-oxide when co-administered with eight CYP3A4/1A2 perpetrators. The population PBPK model of ROF and ROF N-oxide has been successfully developed and validated based on the four clinical PK studies and five clinical drug-drug interactions (DDIs) studies. In PK simulations, every ratio of prediction to observation for PK parameters fell within the range 0.7 to 1.5. In DDI simulations, except for tow peak concentration ratios (...
Source: BMC Pharmacology and Toxicology - January 3, 2024 Category: Drugs & Pharmacology Authors: Guangwei Jia Congcong Ren Hongyan Wang Caixia Fan Source Type: research
A single-blind randomised study comparing the efficacy of fluconazole and itraconazole for the treatment of Malassezia dermatitis in client-owned dogs
CONCLUSIONS AND CLINICAL RELEVANCE: This study indicates that 5FZ and 10FZ are as effective as itraconazole in canine Malassezia dermatitis.PMID:38169074 | DOI:10.1111/vde.13233 (Source: Veterinary Dermatology)
Source: Veterinary Dermatology - January 3, 2024 Category: Veterinary Research Authors: Hayoon Lee Yoonhoi Koo Taesik Yun Dohee Lee Yeon Chae Kyung-Duk Min Hakhyun Kim Mhan-Pyo Yang Byeong-Teck Kang Source Type: research
Evaluation of antifungal activity of natural compounds on growth and aflatoxin B1 production of Aspergillus parasiticus and Aspergillus flavus
CONCLUSION: Our findings showed that the compounds are appropriate alternative candidates against growth and production of aflatoxin of Aspergillus spp.PMID:38165494 | DOI:10.1007/s11033-023-09102-z (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 2, 2024 Category: Molecular Biology Authors: Fariba Moghadasi Shahla Roudbarmohammadi Saied Amanloo Fatemeh Nikoomanesh Maryam Roudbary Source Type: research
Mimicking Charged Host-Defense Peptides to Tune the Antifungal Activity and Biocompatibility of Amphiphilic Polymers
In this study, we developed a library of 29 amphiphilic polyacrylamides with different charged units, namely, amines, guanidinium, imidazole, and carboxylic acid groups, representative of the natural amino acids lysine, arginine, histidine, and glutamic acid. Ternary polymers incorporating primary ammonium (lysine-like) or imidazole (histidine-like) groups demonstrated superior activity against Candida albicans and biocompatibility with mammalian cells compared to the polymers containing the other charged groups. Furthermore, a combination of primary ammonium, imidazole, and guanidinium (arginine-like) within the same poly...
Source: Biomacromolecules - January 2, 2024 Category: Biochemistry Authors: Sebastian Schaefer Daniele Melodia Christopher Pracey Nathaniel Corrigan Megan D Lenardon Cyrille Boyer Source Type: research
Evaluation of antifungal activity of natural compounds on growth and aflatoxin B1 production of Aspergillus parasiticus and Aspergillus flavus
CONCLUSION: Our findings showed that the compounds are appropriate alternative candidates against growth and production of aflatoxin of Aspergillus spp.PMID:38165494 | DOI:10.1007/s11033-023-09102-z (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - January 2, 2024 Category: Molecular Biology Authors: Fariba Moghadasi Shahla Roudbarmohammadi Saied Amanloo Fatemeh Nikoomanesh Maryam Roudbary Source Type: research
Mimicking Charged Host-Defense Peptides to Tune the Antifungal Activity and Biocompatibility of Amphiphilic Polymers
In this study, we developed a library of 29 amphiphilic polyacrylamides with different charged units, namely, amines, guanidinium, imidazole, and carboxylic acid groups, representative of the natural amino acids lysine, arginine, histidine, and glutamic acid. Ternary polymers incorporating primary ammonium (lysine-like) or imidazole (histidine-like) groups demonstrated superior activity against Candida albicans and biocompatibility with mammalian cells compared to the polymers containing the other charged groups. Furthermore, a combination of primary ammonium, imidazole, and guanidinium (arginine-like) within the same poly...
Source: Biomacromolecules - January 2, 2024 Category: Biochemistry Authors: Sebastian Schaefer Daniele Melodia Christopher Pracey Nathaniel Corrigan Megan D Lenardon Cyrille Boyer Source Type: research
Production of new ent-hardwickiic acid derivatives by microbial transformation and their antifungal activity
Fitoterapia. 2023 Dec 30:105810. doi: 10.1016/j.fitote.2023.105810. Online ahead of print.ABSTRACTEnt-hardwickiic acid is the major compound of Copaifera pubiflora Benth oleoresin traditionally used in Brazilian folk medicine as an antimicrobial agent. Microbial transformation of ent-hardwickiic by Cunninghamella elegans ATCC 10028b resulted in two and five antifungal derivatives (four new ones) produced in the Czapek modified and Koch's K1 media, respectively. The derivatives were isolated and their structures were determined by spectral analysis, namely 1D/2D NMR and HR-ESIMS. All compounds were tested for cytotoxic and ...
Source: Fitoterapia - January 1, 2024 Category: Biochemistry Authors: Maria V S Teixeira L ívia M Fernandes Vin ícius S de Paula Ant ônio G Ferreira Loren M Pires Raquel A Santos Niege A J C Furtado Source Type: research
Production of new ent-hardwickiic acid derivatives by microbial transformation and their antifungal activity
Fitoterapia. 2023 Dec 30:105810. doi: 10.1016/j.fitote.2023.105810. Online ahead of print.ABSTRACTEnt-hardwickiic acid is the major compound of Copaifera pubiflora Benth oleoresin traditionally used in Brazilian folk medicine as an antimicrobial agent. Microbial transformation of ent-hardwickiic by Cunninghamella elegans ATCC 10028b resulted in two and five antifungal derivatives (four new ones) produced in the Czapek modified and Koch's K1 media, respectively. The derivatives were isolated and their structures were determined by spectral analysis, namely 1D/2D NMR and HR-ESIMS. All compounds were tested for cytotoxic and ...
Source: Fitoterapia - January 1, 2024 Category: Biochemistry Authors: Maria V S Teixeira L ívia M Fernandes Vin ícius S de Paula Ant ônio G Ferreira Loren M Pires Raquel A Santos Niege A J C Furtado Source Type: research
One-pot synthesis and in vitro bioactivity of novel 4-aminopyrazolo[3,4-b]pyridine derivatives as potential antimicrobial compounds
AbstractThe present paper describes an efficient synthesis of a series of 4-aminopyrazolo[3,4-b]pyridine derivatives11a –i in 69 –81% yields by one-pot three-component domino reaction of phenylhydrazine and two differentβ-ketonitriles in DMSO. All the synthesized derivatives were screened in vitro for their antimicrobial potential against seven Gram-positive and Gram-negative clinical bacterial strains and one fungal strain. Most of the tested derivatives displayed promising antimicrobial potency and activity was found to be comparable to standard drugs (amoxicillin and fluconazole). Compounds11a and11d with the MIC v...
Source: Medicinal Chemistry Research - January 1, 2024 Category: Chemistry Source Type: research
