Widespread dermatophytosis in a healthy adolescent: the first report of multidrug-resistant Trichophyton indotineae infection in the UAE
We describe here the case of a boy with widespread, extremely pruritic, inflammatory dermatophytosis affecting his face, neck, trunk, and extremities, unsuccessfully treated for months with oral terbinafine and fluconazole and a range of topical antimycotics. Qualitative polymerase chain reaction of skin scrapings from his lesions identified a T. interdigitale complex fungus, highly probably T. indotineae due to conspecificity and antifungal resistance. Oral itraconazole, administered over 8 weeks, cleared the infection. Because the patient had not traveled outside the United Arab Emirates for months before the infection b...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - February 13, 2024 Category: Dermatology Authors: Milo š D Pavlović Shireen Marzouk Leis Be ćiri Source Type: research
Rapid Tetra-Primer Amplification Refractory Mutation System-Polymerase Chain Reaction Protocol for Detection of Y132F Mutation in Fluconazole Resistant Candida parapsilosis
Microbial Drug Resistance, Ahead of Print. (Source: Microbial Drug Resistance)
Source: Microbial Drug Resistance - February 12, 2024 Category: Microbiology Authors: Sevgi Öztürk K übra Çam Gizem Babuccu Uzay Altay Onem Serhat Ayd ın Mert Ku şkucu Özlem Doğan Source Type: research
The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model
Candida albicans is the most common fungus that causes vaginal candidiasis in immunocompetent women and catastrophic infections in immunocompromised patients. The treatment of such infections is hindered due to t... (Source: BMC Microbiology)
Source: BMC Microbiology - February 10, 2024 Category: Microbiology Authors: Salwa E. Gomaa, Hisham A. Abbas, Fatma A. Mohamed, Mohamed A. M. Ali, Tarek M. Ibrahim, Alyaa S. Abdel Halim, Mashael A. Alghamdi, Basem Mansour, Anis Ahmad Chaudhary, Amr Elkelish, Fehmi Boufahja, Wael A. H. Hegazy and Fatma Al-zahraa A. Yehia Tags: Research Source Type: research
Safety, Tolerability, and Pharmacokinetics of Voriconazole for Injection in Two Preparations in Chinese Healthy Adult Volunteers
AbstractVoriconazole is a second-generation, synthetic, triazole antifungal drug based on the structure of fluconazole. We compared the safety, tolerability, and pharmacokinetic characteristics of voriconazole for injection (200 mg) manufactured by at a dose of 6 mg/kg in Chinese healthy adult volunteers. This was a single-center, randomized, open, 2-preparation, single-dose, 2-period, 2-sequence, crossover bioequivalence clinical trial. Twenty-four eligible, healthy, male, and female volunteers were assigned randomly to one of 2 dose-sequence groups (test-reference group or reference-test group) in a 1:1 block. The vor...
Source: Clinical Pharmacology in Drug Development - February 8, 2024 Category: Drugs & Pharmacology Authors: Jin Yu,
Yi Wu,
Sisi Lin,
Ying Wang Tags: Original Article Source Type: research
Population pharmacokinetics of cyclosporine A in pediatric patients with thalassemia undergoing allogeneic hematopoietic stem cell transplantation
ConclusionIn the PPK model based on the pediatric cohort on CsA with thalassemia undergoing allogeneic HSCT, WT, POD, FLUC, VORI, POSA, and RBC were found to be the significant factors influencing CL of CsA. The reliability and robustness of the final model were excellent. It is expected that the PPK model can assist in individualizing dosing strategy clinically. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - February 8, 2024 Category: Drugs & Pharmacology Source Type: research
An Insight into the Repurposing of Phytoconstituents obtained from Delhi's Aravalli Biodiversity Park as Antifungal Agents
The objective was to predict or repurpose phyto-based antifungal compounds based on a dual target inhibition approach (Sterol-14-αdemethylase and HSP-90) using a case study. In pursuit of repurposing the phytochemicals as antifungal agents, a team of researchers visited Aravalli Biodiversity Park (ABP), Delhi, India, to collect information on available medicinal plants. From 45 plants, a total of 1149 ligands were collected, and virtual screening was performed using Schrodinger Suite 2016 software to get 83 hits against both the target proteins: Sterol-14-α-demethylase and HSP-90. After analysis of docking results, ligan...
Source: Infectious Disorders Drug Targets - February 2, 2024 Category: Infectious Diseases Authors: Amanpreet Kaur Kalicharan Sharma Neetika Sharma Geeta Aggarwal Source Type: research
SAR study of N'-(Salicylidene)heteroarenecarbohydrazides as promising antifungal agents
Bioorg Med Chem. 2024 Jan 24;100:117610. doi: 10.1016/j.bmc.2024.117610. Online ahead of print.ABSTRACTClinically available antifungal drugs have therapeutic limitations due to toxicity, narrow spectrum of activity, and intrinsic or acquired drug resistance. Thus, there is an urgent need for new broad-spectrum antifungal agents with low toxicity and a novel mechanism of action. In this context, we have successfully identified several highly promising lead compounds, i.e., aromatic N'-(salicylidene)carbohydrazides, exhibiting excellent antifungal activities against Cryptococcus neoformans, Candida albicans, Aspergillus fumi...
Source: Bioorganic and Medicinal Chemistry - February 2, 2024 Category: Chemistry Authors: Yi Sun Saerom Kim SeungYoun Shin Kathryn Takemura Gabriel S Matos Cristina Lazzarini Krupanandan Haranahalli Julia Zambito Ashna Garg Maurizio Del Poeta Iwao Ojima Source Type: research
Physiologically ‐based pharmacokinetic modeling of the drug–drug interaction between ivacaftor and lefamulin in cystic fibrosis patients
AbstractLefamulin is being evaluated as a treatment for bacterial exacerbations in cystic fibrosis (CF). Ivacaftor is approved for the treatment of patients with CF. Lefamulin is a moderate CYP3A inhibitor and co-administration with ivacaftor may result in a drug –drug interaction (DDI). A CF population was built based on literature using the Simcyp Simulator. A previously developed and validated physiologically-based pharmacokinetic (PBPK) model for ivacaftor was used. A PBPK model for lefamulin was developed and verified. Predicted concentrations and pha rmacokinetic (PK) parameters for both ivacaftor and lefamulin in ...
Source: CPT: Pharmacometrics and Systems Pharmacology - February 2, 2024 Category: Drugs & Pharmacology Authors: Magali Amiel,
Alice Ke,
Steven P. Gelone,
Hannah M. Jones,
Wolfgang Wicha Tags: ARTICLE Source Type: research
Limitations of antifungal prophylaxis in preventing invasive < em > Candida < /em > surgical site infections after liver transplant surgery
Antimicrob Agents Chemother. 2024 Feb 1:e0127923. doi: 10.1128/aac.01279-23. Online ahead of print.ABSTRACTInvasive primary Candida surgical site infections (IP-SSIs) are a common complication of liver transplantation, and targeted antifungal prophylaxis is an efficient strategy to limit their occurrence. We performed a retrospective single-center cohort study among adult single liver transplant recipients at Duke University Hospital in the period between 1 January 2015 and 31 December 2020. The study aimed to determine the rate of Candida IP-SSI according to the peri-transplant antifungal prophylaxis received. Of 470 adul...
Source: Antimicrobial Agents and Chemotherapy - February 1, 2024 Category: Microbiology Authors: M Carugati S Arif M E Yarrington L Y King M Harris K Evans A S Barbas D L Sudan J R Perfect R A Miller B D Alexander Source Type: research
Enhanced systematic delivery of fluconazole-loaded biotin-glutathione functionalized chitosan-g-proline carrier into the infected retinitis treatment
The polymer-based facile and effective drug carrier approach was developed to treat superficial fungal infected retinopathy infections. (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - January 30, 2024 Category: Opthalmology Authors: Qing Guo, Zheng Li and Fang Cao Tags: Research Source Type: research
Erratum for McTaggart et al., “First Canadian report of transmission of fluconazole-resistant Candida parapsilosis within two hospital networks confirmed by genomic analysis”
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 26, 2024 Category: Microbiology Authors: Lisa R. McTaggartAliReza EshaghiSusy HotaSusan M. PoutanenJennie JohnstoneDomenica G. De LucaAmrita BharatSamir N. PatelJulianne V. Kus Source Type: research
Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial Candida glabrata isolates
Journal of Clinical Microbiology, Ahead of Print. (Source: Journal of Clinical Microbiology)
Source: Journal of Clinical Microbiology - January 24, 2024 Category: Microbiology Authors: E. MisasE. SeagleE. N. JenkinsM. RajeevS. HurstN. S. NunnallyM. L. BentzM. M. LymanE. BerkowL. H. HarrisonW. SchaffnerT. M. MarkusR. PierceM. M. FarleyN. A. ChowS. R. LockhartA. P. Litvintseva1Mycotic Diseases Branch, Centers for Disease Control and Pr Source Type: research
