Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Promising activity of etomidate against mixed biofilms of fluconazole-resistant < em > Candida albicans < /em > and methicillin-resistant < em > Staphylococcus aureus < /em >
Conclusion. The results showed the potential of etomidate against polymicrobial biofilms of fluconazole-resistant C. albicans and MRSA.PMID:38385528 | DOI:10.1099/jmm.0.001810 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 22, 2024 Category: Microbiology Authors: Cec ília Rocha da Silva J úlia Délis de Oliveira Rebouças Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Amanda Dias Barbosa Lara Elloyse Almeida Moreira F átima Daiana Dias Barroso Tatiana do Nascimento Paiva Coutinho Elaine Aires de Lim Source Type: research
Synthesis, antibacterial activity, and 3D-QASR studies of matrine-indole derivatives as potential antibiotics
Bioorg Med Chem Lett. 2024 Feb 20:129671. doi: 10.1016/j.bmcl.2024.129671. Online ahead of print.ABSTRACTMatrine and indole have antibacterial, anticancer, and other biological activities, in order to develop new antibiotics to solve the problem of multi-drug resistant bacteria. In this paper, we synthesized a series of 29 novel matrine derivatives as potential drug candidates by combining indole analogs and matrine. The antibacterial activity of these compounds was evaluated through minimum inhibitory concentration (MIC) assays against five bacterial strains (S. aureus, C. albicans, P. acnes, P. aeruginosa, and E. coli). ...
Source: Bioorganic and Medicinal Chemistry Letters - February 22, 2024 Category: Chemistry Authors: Yufang Li Jamal A H Kowah Meiyan Jiang Yaqing Wu Lisheng Wang Fangfang Yang Source Type: research
Promising activity of etomidate against mixed biofilms of fluconazole-resistant < em > Candida albicans < /em > and methicillin-resistant < em > Staphylococcus aureus < /em >
Conclusion. The results showed the potential of etomidate against polymicrobial biofilms of fluconazole-resistant C. albicans and MRSA.PMID:38385528 | DOI:10.1099/jmm.0.001810 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 22, 2024 Category: Microbiology Authors: Cec ília Rocha da Silva J úlia Délis de Oliveira Rebouças Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Amanda Dias Barbosa Lara Elloyse Almeida Moreira F átima Daiana Dias Barroso Tatiana do Nascimento Paiva Coutinho Elaine Aires de Lim Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Synthesis, antibacterial activity, and 3D-QASR studies of matrine-indole derivatives as potential antibiotics
Bioorg Med Chem Lett. 2024 Feb 20:129671. doi: 10.1016/j.bmcl.2024.129671. Online ahead of print.ABSTRACTMatrine and indole have antibacterial, anticancer, and other biological activities, in order to develop new antibiotics to solve the problem of multi-drug resistant bacteria. In this paper, we synthesized a series of 29 novel matrine derivatives as potential drug candidates by combining indole analogs and matrine. The antibacterial activity of these compounds was evaluated through minimum inhibitory concentration (MIC) assays against five bacterial strains (S. aureus, C. albicans, P. acnes, P. aeruginosa, and E. coli). ...
Source: Bioorganic and Medicinal Chemistry Letters - February 22, 2024 Category: Chemistry Authors: Yufang Li Jamal A H Kowah Meiyan Jiang Yaqing Wu Lisheng Wang Fangfang Yang Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Promising activity of etomidate against mixed biofilms of fluconazole-resistant < em > Candida albicans < /em > and methicillin-resistant < em > Staphylococcus aureus < /em >
Conclusion. The results showed the potential of etomidate against polymicrobial biofilms of fluconazole-resistant C. albicans and MRSA.PMID:38385528 | DOI:10.1099/jmm.0.001810 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 22, 2024 Category: Microbiology Authors: Cec ília Rocha da Silva J úlia Délis de Oliveira Rebouças Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Amanda Dias Barbosa Lara Elloyse Almeida Moreira F átima Daiana Dias Barroso Tatiana do Nascimento Paiva Coutinho Elaine Aires de Lim Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Promising activity of etomidate against mixed biofilms of fluconazole-resistant < em > Candida albicans < /em > and methicillin-resistant < em > Staphylococcus aureus < /em >
Conclusion. The results showed the potential of etomidate against polymicrobial biofilms of fluconazole-resistant C. albicans and MRSA.PMID:38385528 | DOI:10.1099/jmm.0.001810 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 22, 2024 Category: Microbiology Authors: Cec ília Rocha da Silva J úlia Délis de Oliveira Rebouças Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Amanda Dias Barbosa Lara Elloyse Almeida Moreira F átima Daiana Dias Barroso Tatiana do Nascimento Paiva Coutinho Elaine Aires de Lim Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
