PHARMACOLOGICAL POTENTIAL OF LIMONENE AGAINST OPPORTUNISTIC FUNGI: IMPACT ON Candida VIRULENCE
Acta Trop. 2024 Mar 1:107168. doi: 10.1016/j.actatropica.2024.107168. Online ahead of print.ABSTRACTThe present article aims to evaluate the antifungal and antivirulence effect of the phytoconstituent Limonene against Candida spp. Antifungal assays were performed, where the concentration capable of inhibiting 50% of fungal growth, the growth inhibition curve, the minimum fungicidal concentration, the evaluation of the modifying effect with fluconazole, the inhibitory effect of the substances on the morphological transition of Candida spp. and the statistical analysis of the results were determined. With this study, it was ...
Source: Acta Tropica - March 3, 2024 Category: Infectious Diseases Authors: Maria Hellena Garcia Novais Naiza Saraiva Farias Andressa Guilhermino Dos Santos Victor Juno Alencar Fonseca Jaime Ribeiro-Filho Irwin Rose Alencar de Menezes Henrique Douglas Melo Coutinho Maria Flaviana Bezerra Morais-Braga Source Type: research
Synthesis and antimicrobial activity evaluation of pyridine derivatives containing imidazo[2,1-b][1,3,4]thiadiazole moiety
Chem Biodivers. 2024 Feb 29:e202400135. doi: 10.1002/cbdv.202400135. Online ahead of print.ABSTRACTFour series of novel pyridine derivatives (17a-i, 18a-i, 19a-e, and 20a-e) were synthesized and their antimicrobial activities were evaluated. Of all the target compounds, almost half target compounds showed moderate or high antibacterial activity. The 4-F substituted compound 17d (MIC = 0.5 µg/mL) showed the highest antibacterial activity, its activity was twice the positive control compound gatifloxacin (MIC = 1.0 µg/mL). For fungus ATCC 9763, the activities of compounds 17a and 17d are equivalent to the positive control ...
Source: Chemistry and Biodiversity - March 1, 2024 Category: Biochemistry Authors: Liu Yang Yu-Xin Jiao Yan-Hua Quan Ming-Yu Li Xin-Yi Huang Jun-Zheng Jin Siqi Li Ji-Shan Quan Cheng-Hua Jin Source Type: research
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant < em > C. albicans < /em > and methicillin-resistant < em > S. aureus < /em > in catheters
The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus, by reducing the cell viability of mixed biofilms of...
Source: Biofouling - March 1, 2024 Category: Molecular Biology Authors: Cec ília Rocha da Silva L ívia Gurgel do Amaral Valente Sá Jo ão Batista de Andrade Neto F átima Daiana Dias Barroso Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Lisandra Juv êncio da Silva Iri Sandro Pampolha Lima Lourdes P érez Ande Source Type: research
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant < em > C. albicans < /em > and methicillin-resistant < em > S. aureus < /em > in catheters
The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus, by reducing the cell viability of mixed biofilms of...
Source: Biofouling - March 1, 2024 Category: Molecular Biology Authors: Cec ília Rocha da Silva L ívia Gurgel do Amaral Valente Sá Jo ão Batista de Andrade Neto F átima Daiana Dias Barroso Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Lisandra Juv êncio da Silva Iri Sandro Pampolha Lima Lourdes P érez Ande Source Type: research
Synthesis and antimicrobial activity evaluation of pyridine derivatives containing imidazo[2,1-b][1,3,4]thiadiazole moiety
Chem Biodivers. 2024 Feb 29:e202400135. doi: 10.1002/cbdv.202400135. Online ahead of print.ABSTRACTFour series of novel pyridine derivatives (17a-i, 18a-i, 19a-e, and 20a-e) were synthesized and their antimicrobial activities were evaluated. Of all the target compounds, almost half target compounds showed moderate or high antibacterial activity. The 4-F substituted compound 17d (MIC = 0.5 µg/mL) showed the highest antibacterial activity, its activity was twice the positive control compound gatifloxacin (MIC = 1.0 µg/mL). For fungus ATCC 9763, the activities of compounds 17a and 17d are equivalent to the positive control ...
Source: Chemistry and Biodiversity - March 1, 2024 Category: Biochemistry Authors: Liu Yang Yu-Xin Jiao Yan-Hua Quan Ming-Yu Li Xin-Yi Huang Jun-Zheng Jin Siqi Li Ji-Shan Quan Cheng-Hua Jin Source Type: research
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant < em > C. albicans < /em > and methicillin-resistant < em > S. aureus < /em > in catheters
The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus, by reducing the cell viability of mixed biofilms of...
Source: Biofouling - March 1, 2024 Category: Molecular Biology Authors: Cec ília Rocha da Silva L ívia Gurgel do Amaral Valente Sá Jo ão Batista de Andrade Neto F átima Daiana Dias Barroso Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Lisandra Juv êncio da Silva Iri Sandro Pampolha Lima Lourdes P érez Ande Source Type: research
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant < em > C. albicans < /em > and methicillin-resistant < em > S. aureus < /em > in catheters
The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus, by reducing the cell viability of mixed biofilms of...
Source: Biofouling - March 1, 2024 Category: Molecular Biology Authors: Cec ília Rocha da Silva L ívia Gurgel do Amaral Valente Sá Jo ão Batista de Andrade Neto F átima Daiana Dias Barroso Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Lisandra Juv êncio da Silva Iri Sandro Pampolha Lima Lourdes P érez Ande Source Type: research
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant < em > C. albicans < /em > and methicillin-resistant < em > S. aureus < /em > in catheters
The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus, by reducing the cell viability of mixed biofilms of...
Source: Biofouling - March 1, 2024 Category: Molecular Biology Authors: Cec ília Rocha da Silva L ívia Gurgel do Amaral Valente Sá Jo ão Batista de Andrade Neto F átima Daiana Dias Barroso Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Lisandra Juv êncio da Silva Iri Sandro Pampolha Lima Lourdes P érez Ande Source Type: research
Antimicrobial potential of a biosurfactant gel for the prevention of mixed biofilms formed by fluconazole-resistant < em > C. albicans < /em > and methicillin-resistant < em > S. aureus < /em > in catheters
The objective of this study was to evaluate the antibiofilm activity of RLmix_Arg, both alone and incorporated in a gel prepared with Pluronic F-127, against dual-species biofilms of fluconazole-resistant C. albicans (FRCA) and methicillin-resistant S. aureus (MRSA) in impregnated catheters. Broth microdilution tests, MTT reduction assays of mature biofilms, impregnation of RLmix_Arg and its gel in peripheral venous catheters, durability tests and scanning electron microscopy (SEM) were performed. RLmix_Arg showed antimicrobial activity against Candida spp. and S. aureus, by reducing the cell viability of mixed biofilms of...
Source: Biofouling - March 1, 2024 Category: Molecular Biology Authors: Cec ília Rocha da Silva L ívia Gurgel do Amaral Valente Sá Jo ão Batista de Andrade Neto F átima Daiana Dias Barroso Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Lisandra Juv êncio da Silva Iri Sandro Pampolha Lima Lourdes P érez Ande Source Type: research
Oral Candida carriage and resistance against common antifungal agents in hematopoietic stem cell transplantation recipients
ConclusionOralCandida carriage increases after HSCT. Instead of the expected development of resistance ofC. albicans against fluconazole, the relative proportion of non-albicans strains with innate resistance against azole-group antifungals increased. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - February 23, 2024 Category: Cancer & Oncology Source Type: research
Vesicovaginal and vesicorectal fistula in a patient with systemic sclerosis: A case report
Key Clinical MessageThis case highlights the need for further research to explore a potential link between systemic sclerosis and fistula development, and the importance of raising awareness among clinicians about this possibility for timely appropriate management.AbstractThe primary diagnosis in this case is systemic sclerosis (scleroderma) in a 47-year-old female patient with various clinical manifestations, including vesicovaginal and vesicorectal fistulas. The medical interventions and diagnostic workup involved an electrocardiogram, cardiac echocardiogram, pulmonary function tests, beta blockers, aspirin, inhaled cort...
Source: Clinical Case Reports - February 22, 2024 Category: General Medicine Authors: Mohammad Quteineh,
Sajedah N. Obeid,
Khayry Al ‐Shami,
Hamdah Hanifa Tags: CASE REPORT Source Type: research
Synthesis, antibacterial activity, and 3D-QASR studies of matrine-indole derivatives as potential antibiotics
Bioorg Med Chem Lett. 2024 Feb 20:129671. doi: 10.1016/j.bmcl.2024.129671. Online ahead of print.ABSTRACTMatrine and indole have antibacterial, anticancer, and other biological activities, in order to develop new antibiotics to solve the problem of multi-drug resistant bacteria. In this paper, we synthesized a series of 29 novel matrine derivatives as potential drug candidates by combining indole analogs and matrine. The antibacterial activity of these compounds was evaluated through minimum inhibitory concentration (MIC) assays against five bacterial strains (S. aureus, C. albicans, P. acnes, P. aeruginosa, and E. coli). ...
Source: Bioorganic and Medicinal Chemistry Letters - February 22, 2024 Category: Chemistry Authors: Yufang Li Jamal A H Kowah Meiyan Jiang Yaqing Wu Lisheng Wang Fangfang Yang Source Type: research
Drug-Drug Interaction between Tacrolimus and Fluconazole in a Kidney Transplant Recipient
We report a case of tacrolimus and fluconazole drug-drug interaction in a 20-year-old female kidney transplant recipient with stable kidney function. The patient's tacrolimus blood concentrations were in the therapeutic range until fluconazole was administrated for Candida albicans infection, on day 58 posttransplant. Tacrolimus blood concentration increased by 125% (18.4 ng/mL) on day 79 and by 212% (25.4 ng/mL) on day 84 posttransplant. On day 92, tacrolimus trough blood concentration returned to the therapeutic range (5.6 ng/mL), with decrease of tacrolimus daily dose by 50% (to 4 mg). After fluconazole withdrawal, the ...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - February 22, 2024 Category: Transplant Surgery Authors: Khouloud Ferchichi Syrine Ben Hammamia Mouna Ben Sassi Hanene El Jebari Rim Charfi Riadh Daghfous Emna Gaies Sameh Trabelsi Source Type: research
Promising activity of etomidate against mixed biofilms of fluconazole-resistant < em > Candida albicans < /em > and methicillin-resistant < em > Staphylococcus aureus < /em >
Conclusion. The results showed the potential of etomidate against polymicrobial biofilms of fluconazole-resistant C. albicans and MRSA.PMID:38385528 | DOI:10.1099/jmm.0.001810 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - February 22, 2024 Category: Microbiology Authors: Cec ília Rocha da Silva J úlia Délis de Oliveira Rebouças Vit ória Pessoa de Farias Cabral Daniel Sampaio Rodrigues Amanda Dias Barbosa Lara Elloyse Almeida Moreira F átima Daiana Dias Barroso Tatiana do Nascimento Paiva Coutinho Elaine Aires de Lim Source Type: research
Synthesis, antibacterial activity, and 3D-QASR studies of matrine-indole derivatives as potential antibiotics
Bioorg Med Chem Lett. 2024 Feb 20:129671. doi: 10.1016/j.bmcl.2024.129671. Online ahead of print.ABSTRACTMatrine and indole have antibacterial, anticancer, and other biological activities, in order to develop new antibiotics to solve the problem of multi-drug resistant bacteria. In this paper, we synthesized a series of 29 novel matrine derivatives as potential drug candidates by combining indole analogs and matrine. The antibacterial activity of these compounds was evaluated through minimum inhibitory concentration (MIC) assays against five bacterial strains (S. aureus, C. albicans, P. acnes, P. aeruginosa, and E. coli). ...
Source: Bioorganic and Medicinal Chemistry Letters - February 22, 2024 Category: Chemistry Authors: Yufang Li Jamal A H Kowah Meiyan Jiang Yaqing Wu Lisheng Wang Fangfang Yang Source Type: research
