Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient
We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifun...
Source: Anales del Sistema Sanitario de Navarra - March 7, 2024 Category: General Medicine Authors: Juli án Castro Castro Mar ía Dolores Díaz López Source Type: research
Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient
We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifun...
Source: Anales del Sistema Sanitario de Navarra - March 7, 2024 Category: General Medicine Authors: Juli án Castro Castro Mar ía Dolores Díaz López Source Type: research
Cryptococcal meningitis associated with hydrocephalus in an immunocompetent patient
We present the case of a 67-year-old male who was admitted for subacute symptoms of gait disturbance and urinary incontinence. Neurological examination revealed inability to stand and memory impairment. Cranial imaging showed obstructive tetraventricular hydrocephalus with areas of gliosis in the cerebellar peduncles. Endoscopic treatment of hydrocephalus was performed and cerebrospinal fluid samples taken revealing the growth of Cryptococcus neoformans. The patient improved with the endoscopic treatment and after completing intravenous antifungal therapy with liposomal amphotericin B and fluconazole for ten weeks. Antifun...
Source: Anales del Sistema Sanitario de Navarra - March 7, 2024 Category: General Medicine Authors: Juli án Castro Castro Mar ía Dolores Díaz López Source Type: research
GSE260902 Effect of Replicative Aging on Cryptococcus neoformans
Contributors : Kyungyoon Yoo ; Natalia Kronbauer Oliveira ; Somanon Bhattacharya ; Bettina C FriesSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformansCryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells accumulating during chronic infections. This is attributed to their enhanced resistance to phagocytic killing and tolerance of antifungals like fluconazole (FLC). Using RNA-seq, ...
Source: GEO: Gene Expression Omnibus - March 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cryptococcus neoformans Source Type: research
Isolation and identification of Wickerhamiella tropicalis from blood culture by MALDI-MS
In this study, we isolated W. tropicalis from a blood sample of a six-year-old female with a history of B-cell precursor lymphoblastic leukemia in Japan in 2022. Though the strain was morphologically identified as Candida species by routine microbiological examinations, it was subsequently identified as W. tropicalis by sequencing the internal transcribed spacer (ITS) of ribosomal DNA (rDNA). The isolate had amino acid substitutions in ERG11 and FKS1 associated with azole and echinocandin resistance, respectively, in Candida species and showed intermediate-resistant to fluconazole and micafungin. The patient was successful...
Source: Frontiers in cellular and infection microbiology - March 6, 2024 Category: Microbiology Source Type: research
Novel automated antifungal susceptibility testing system for yeasts based on dual-detection algorithm of turbidimetry and colorimetry
Conclusion. Given the above, it can be argued that the utilization of Fungus AST is a discretionary automated approach. More improvements are needed in Fungus AST compared to the BMD system for a wider range of clinical isolates, including different types of fungi.PMID:38440953 | DOI:10.1099/jmm.0.001811 (Source: Journal of Medical Microbiology)
Source: Journal of Medical Microbiology - March 5, 2024 Category: Microbiology Authors: Tingting Shen Piao Liu Dongmiao Chen Duoduo Liu Juan Fang Qian Wang Yinjuan Xu Chunjuan Tan Congrong Wang Source Type: research
