GSE260902 Effect of Replicative Aging on Cryptococcus neoformans

Contributors : Kyungyoon Yoo ; Natalia Kronbauer Oliveira ; Somanon Bhattacharya ; Bettina C FriesSeries Type : Expression profiling by high throughput sequencingOrganism : Cryptococcus neoformansCryptococcus neoformans (Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells accumulating during chronic infections. This is attributed to their enhanced resistance to phagocytic killing and tolerance of antifungals like fluconazole (FLC). Using RNA-seq, we investigated how transcriptomic changes in different aspects of metabolism contribute to age-associated FLC tolerance in Cn.

Source: GEO: Gene Expression Omnibus - March 6, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Cryptococcus neoformans Source Type: research