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FTC approves Baxter ’ s $625m Claris buyout, with conditions
The Federal Trade Commission approved Baxter‘s (NYSE:BAX) $625 million acquisition of Claris Lifesciences‘ (BOM:533288) injectable drug biz, but mandated that the companies divest two drugs products – an antifungal agent, fluconazole, and intravenous milrinone. The FTC filed a complaint saying that the original deal would likely reduce competition in the U.S. for fluconazole since Baxter and Claris represent two of the four significant competitors selling fluconazole in saline intravenous bags. Combined, they hold an estimated market share of 60%, according to the FTC. Get the full story at our siste...
Source: Mass Device - July 21, 2017 Category: Medical Devices Authors: Sarah Faulkner Tags: Drug-Device Combinations Mergers & Acquisitions Pharmaceuticals Wall Street Beat Baxter Claris Lifesciences Source Type: news

The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we describe the characterization of the spectrum of in vitro activity and in vivo activity of AR-12, a celecoxib derivative which has been tested in a phase I clinical trial as an anticancer agent. AR-12 inhibits fungal acetyl coenzyme A (acetyl-CoA) synthetase in vitro and is fungicidal at concentrations similar to those achieved in human plasma. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - June 20, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Antifungal peptides: a potential new class of antifungals for treating vulvovaginal candidiasis caused by fluconazole-resistant Candida albicans.
Vulvovaginal candidiasis/candidosis is a common fungal infection afflicting approximately 75% of women globally caused primarily by the yeast Candida albicans. Fluconazole is widely regarded as the antifungal drug of choice since its introduction in 1990 due to its high oral bioavailability, convenient dosing regimen and favourable safety profile. However, its widespread use has led to the emergence of fluconazole-resistant C. albicans, posing a universal clinical concern. (Source: The Aspergillus Website - updates)
Source: The Aspergillus Website - updates - April 24, 2017 Category: Respiratory Medicine Authors: GAtherton Source Type: news

Drug-Resistant Fungus Spreads Among U.S. Healthcare Facilities
This article was updated from a Nov. 2016 story on C. auris.  This reporting is brought to you by HuffPost’s health and science platform, The Scope. Like us on Facebook and Twitter and tell us your story: scopestories@huffingtonpost.com.    -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website. (Source: Healthy Living - The Huffington Post)
Source: Healthy Living - The Huffington Post - March 21, 2017 Category: Consumer Health News Source Type: news

Zydus gets USFDA nod for fungal infections, skin disorder drug
The company has received final approval from the USFDA to market Fluconazole tablets USP and Clobetasol Propionate Spray (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 17, 2017 Category: Pharmaceuticals Source Type: news

Zydus Cadila receives USFDA nod to market fluconazole tablets
The company also received approval for Clobetasol Propionate spray used in the treatment of various skin disorders. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - February 17, 2017 Category: Pharmaceuticals Source Type: news

This Is The First Drug-Resistant Fungus Found In The U.S.
A drug-resistant fungus that first emerged in the U.S. only a few years ago has been linked to four deaths, and health officials are on guard about its potential to spread in healthcare facilities throughout the country.  C. auris, a yeast that has sickened people around the globe and caused potentially deadly infections, appears to have arrived in the U.S. a few years ago, according to the first report on C. auris released by the U.S. Centers for Disease Control and Prevention. Because C. auris cases have cropped up in other countries, the CDC decided to alert all U.S. clinics, labs...
Source: Healthy Living - The Huffington Post - November 5, 2016 Category: Consumer Health News Source Type: news

This Is The First Drug-Resistant Fungus Found In The U.S.
A drug-resistant fungus that first emerged in the U.S. only a few years ago has been linked to four deaths, and health officials are on guard about its potential to spread in healthcare facilities throughout the country.  C. auris, a yeast that has sickened people around the globe and caused potentially deadly infections, appears to have arrived in the U.S. a few years ago, according to the first report on C. auris released by the U.S. Centers for Disease Control and Prevention. Because C. auris cases have cropped up in other countries, the CDC decided to alert all U.S. clinics, labs...
Source: Science - The Huffington Post - November 5, 2016 Category: Science Source Type: news

The First Cases Of Drug-Resistant Fungus Candida Auris Found In The U.S.
A drug-resistant fungus that first emerged in the U.S. only a few years ago has been linked to four deaths, and health officials are on guard about its potential to spread in healthcare facilities throughout the country.  C. auris, a yeast that has sickened people around the globe and caused potentially deadly infections, appears to have arrived in the U.S. a few years ago, according to the first report on C. auris released by the U.S. Centers for Disease Control and Prevention. Because C. auris cases have cropped up in other countries, the CDC decided to alert all U.S. clinics, labs...
Source: Healthy Living - The Huffington Post - November 5, 2016 Category: Consumer Health News Source Type: news

The First Cases Of Drug-Resistant Fungus Candida Auris Found In The U.S.
A drug-resistant fungus that first emerged in the U.S. only a few years ago has been linked to four deaths, and health officials are on guard about its potential to spread in healthcare facilities throughout the country.  C. auris, a yeast that has sickened people around the globe and caused potentially deadly infections, appears to have arrived in the U.S. a few years ago, according to the first report on C. auris released by the U.S. Centers for Disease Control and Prevention. Because C. auris cases have cropped up in other countries, the CDC decided to alert all U.S. clinics, labs...
Source: Science - The Huffington Post - November 5, 2016 Category: Science Source Type: news

Disrupting mitochondrial function could improve treatment of fungal infections
By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50 percent and cause an estimated 1.5 million deaths worldwide annually. Current antifungal therapies are hampered by the increasingly frequent emergence of drug resistance and negative interactions that often preclude combination use. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - August 11, 2016 Category: Science Source Type: news

Disrupting mitochondrial function could improve treatment of fungal infections
(Whitehead Institute for Biomedical Research) By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, Whitehead Institute scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50 percent and cause an estimated 1.5 million deaths worldwide annually. Current antifungal therapies are hampered by the increasingly frequent emergence of drug resistance and negative interactions that often preclud...
Source: EurekAlert! - Medicine and Health - August 11, 2016 Category: Global & Universal Source Type: news

Diflucan (Fluconazole) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 19, 2016 Category: Drugs & Pharmacology Source Type: news

Candida auris: laboratory investigation, management and infection prevention and control
This document provides guidance about sending Candida spp isolates for laboratory testing, treatment and decolonisation of patients and screening in hospitals, and infection prevention and control measures. Candida auris is a pathogenic yeast species that has been reported to cause bloodstream infections, wound infections, and otitis. It has also been cultured from urine and the respiratory tract. Unlike other pathogenic yeast species, C. auris appears to have a propensity for transmission between hospital patients. It is commonly resistant to the first-line antifungal, fluconazole and can develop resistance to other class...
Source: Current Awareness Service for Health (CASH) - July 13, 2016 Category: Consumer Health News Source Type: news

Fluconazole Injection (Fluconazole Injection) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 10, 2016 Category: Drugs & Pharmacology Source Type: news

F.D.A. Urges Caution on Yeast Infection Drug During Pregnancy
The agency had previously warned that high doses of the drug, fluconazole, might be linked to birth defects. A new study suggests dangers at lower doses. (Source: NYT Health)
Source: NYT Health - April 27, 2016 Category: Consumer Health News Authors: CATHERINE SAINT LOUIS Tags: Pregnancy and Childbirth Drugs (Pharmaceuticals) Yeast Infections Miscarriages Food and Drug Administration fluconazole Source Type: news

Yeast Infection Drug May Raise Miscarriage Risk
Agency recommends alternatives to fluconazole for mothers-to-be until its review is complete (Source: WebMD Health)
Source: WebMD Health - April 26, 2016 Category: Consumer Health News Source Type: news

FDA: Yeast Infection Drug Might Increase Miscarriage Risk (FREE)
By Kristin J. Kelley Edited by Lorenzo Di Francesco, MD, FACP, FHM Clinicians should exercise caution when prescribing the oral antifungal fluconazole (Diflucan and generics) to pregnant women, the FDA warned on Tuesday, because the drug might pose increased … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - April 26, 2016 Category: Primary Care Source Type: news

Yeast infection drug may raise miscarriage risk, FDA warns
HealthDay News Doctors should use caution when prescribing the antifungal drug fluconazole during pregnancy because it may raise the risk of miscarriage, the FDA warns. (Source: Health News - UPI.com)
Source: Health News - UPI.com - April 26, 2016 Category: Consumer Health News Source Type: news

Drug for Yeast Infections May Raise Miscarriage Risk, FDA Warns
Agency recommends alternatives to fluconazole for mothers-to-be until its review is complete Source: HealthDay Related MedlinePlus Pages: Miscarriage, Pregnancy, Yeast Infections (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - April 26, 2016 Category: Consumer Health News Source Type: news

Low-Dose Fluconazole in Pregnancy Worries FDALow-Dose Fluconazole in Pregnancy Worries FDA
Clinicians should exercise caution prescribing oral fluconazole to treat yeast infections in pregnant women, given new evidence that even low doses may cause miscarriages, the agency said. News Alerts (Source: Medscape FamilyMedicine Headlines)
Source: Medscape FamilyMedicine Headlines - April 26, 2016 Category: Primary Care Tags: Ob/Gyn & Women ' s Health News Alert Source Type: news

FDA Probes Fluconazole Risks in Pregnancy
(MedPage Today) -- "Cautious prescribing" urged until safety review is complete (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - April 26, 2016 Category: American Health Source Type: news

Drug for Yeast Infections May Raise Miscarriage Risk, FDA Warns
TUESDAY, April 26, 2016 -- Doctors should use caution when prescribing the antifungal drug fluconazole during pregnancy because it may raise the risk of miscarriage, the U.S. Food and Drug Administration warns. Fluconazole (brand name Diflucan) is... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - April 26, 2016 Category: Journals (General) Source Type: news

FDA Drug Safety Communication: FDA to review study examining use of oral fluconazole (Diflucan) in pregnancy
The U.S. Food and Drug Administration (FDA) is evaluating the results of a Danish study1 that concludes there is a possible increased risk of miscarriage with the use of oral fluconazole (Diflucan) for yeast infections. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - April 26, 2016 Category: Drugs & Pharmacology Source Type: news

Tropical Fruit For Natural Yeast Infection Treatment
I’ve seen the health benefits of coconut among numerous traditional cultures in Bali, India, Peru, Jamaica and various parts of Africa. They use it for almost everything — from lip balm and skin moisturizer to cooking oil and a remedy for stomach complaints. For years, coconut fat was demonized as the enemy of heart health — until multiple studies revealed that it’s chock full of antioxidants and vitamin E. It also contains a unique kind of fat called medium-chain triglycerides, or MCTs — and these are extremely good for your heart. Coconut Health Benefits: Help prevent obesity by speeding u...
Source: Al Sears, MD Natural Remedies - March 28, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news

FDA Drug Safety Communication:Use of long-term, high-dose Diflucan (fluconazole) during pregnancy may be associated with birth defects in infants
[8-03-2011] The U.S. Food and Drug Administration (FDA) is informing the public that chronic, high doses (400-800 mg/day) of the antifungal drug Diflucan (fluconazole) may be associated with a rare and distinct set of birth defects in infants whose mothers were treated with the drug during the first trimester of pregnancy. (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 11, 2016 Category: Drugs & Pharmacology Source Type: news

Lack of stem cells in womb linked to miscarriage
Finding could herald new treatments Related items from OnMedicaMiscarriage care must change, says mumsnetQuarter of miscarriages could be prevented Fluconazole linked to increased risk of miscarriageEndometriosis increases risk of miscarriage and ectopic pregnancy (Source: OnMedica Latest News)
Source: OnMedica Latest News - March 8, 2016 Category: UK Health Source Type: news

Sagent Pharmaceuticals Initiates a Nationwide Voluntary Recall of Fluconazole Injection, USP, (in 0.9% Sodium Chloride) 200mg per 100ml Due to the Discovery of an Out of Specification Impurity Result Detected During Routine Quality Testing of Stability Samples at the 18-Month Interval
Sagent Pharmaceuticals, Inc. today announced the voluntary nationwide recall of one lot of Fluconazole Injection, USP, (in 0.9% Sodium Chloride) 200mg per 100mL flexible container bag (NDC 25021-113-82) Lot 40608 manufactured by ACS Dobfar INFO S.A. and distributed by Sagent. Sagent has initiated this voluntary recall of Fluconazole Injection, USP, 200mg per 100mL to the user level due to the discovery of an out of specification impurity result detected during routine quality testing of stability samples at the 18-month interval. (Source: Food and Drug Administration)
Source: Food and Drug Administration - March 4, 2016 Category: Food Science Source Type: news

Meningitis Still Seen With Preemptive Fluconazole (CME/CE)
(MedPage Today) -- Attempts to prevent brain disease and death fall short (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - February 26, 2016 Category: Infectious Diseases Source Type: news

Oral Antifungal in Pregnancy Increases Miscarriage RiskOral Antifungal in Pregnancy Increases Miscarriage Risk
Oral fluconazole, sometimes prescribed for vaginal candidiasis in pregnancy when a topical azole fails, was associated in a large study with a significantly increased risk for spontaneous abortions. Medscape Medical News (Source: Medscape ObGyn and Womens Health Headlines)
Source: Medscape ObGyn and Womens Health Headlines - January 5, 2016 Category: OBGYN Tags: Ob/Gyn & Women ' s Health News Source Type: news

Antifungal for Yeast Infections Tied to Miscarriage Risk
The oral drug fluconazole may increase the risk, Danish researchers say Source: HealthDay Related MedlinePlus Pages: Miscarriage, Pregnancy, Yeast Infections (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - January 5, 2016 Category: Consumer Health News Source Type: news

New Guideline Calls for Aggressive Treatment of CandidiasisNew Guideline Calls for Aggressive Treatment of Candidiasis
Start early therapy for candidemia with an echinocandin, not fluconazole, updated recommendations say. Medscape Medical News (Source: Medscape Critical Care Headlines)
Source: Medscape Critical Care Headlines - December 24, 2015 Category: Intensive Care Tags: Infectious Diseases News Source Type: news

Claris gets USFDA supplemental nod for Fluconazole injection
The drug firm said it markets its products through a wholly-owned subsidiary Claris Lifesciences Inc. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 21, 2015 Category: Pharmaceuticals Source Type: news

fluconazole, Diflucan
Title: fluconazole, DiflucanCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 12/31/2014 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 31, 2014 Category: Drugs & Pharmacology Source Type: news

Medication does not lower risk of fungal infection, death among extremely below weight infants
Use of the antifungal medication fluconazole for six weeks for extremely low birth-weight infants did not significantly reduce the risk of death or invasive candidiasis, a serious infection that occurs when candida -- a type of fungus -- enters the bloodstream and spreads through the body, according to a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 4, 2014 Category: Science Source Type: news

Medication does not lower risk of fungal infection, death among ELBW infants
(The JAMA Network Journals) Use of the antifungal medication fluconazole for six weeks for extremely low birth-weight infants did not significantly reduce the risk of death or invasive candidiasis, a serious infection that occurs when candida -- a type of fungus -- enters the bloodstream and spreads through the body, according to a study in the May 7 issue of JAMA, a theme issue on child health. This issue is being released early to coincide with the Pediatric Academic Societies Annual Meeting. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - May 3, 2014 Category: Infectious Diseases Source Type: news

Fluconazole and Birth Defects: How Much Risk?Fluconazole and Birth Defects: How Much Risk?
A large cohort study evaluates the risk for 15 birth defects with fluconazole use in pregnancy. Medscape Pediatrics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 28, 2013 Category: Consumer Health News Tags: Pediatrics Viewpoint Source Type: news

Yeast Infection Drug Bypassing Fluconazole Resistance FailsYeast Infection Drug Bypassing Fluconazole Resistance Fails
An experimental drug designed to treat vulvovaginal candidiasis has failed in a phase 2 trial. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 19, 2013 Category: Consumer Health News Tags: Infectious Diseases News Source Type: news

Featured in NEJM Journal Watch: Safety of Fluconazole During Pregnancy (FREE)
By the NEJM Journal Watch Editors First-trimester use of typical therapeutic doses of oral fluconazole for yeast infections was not associated with excess risk for overall … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - August 29, 2013 Category: Primary Care Source Type: news

Anti-Fungal Drug Not Tied to Most Birth Defects: Study
But experts may still avoid prescribing fluconazole for pregnant women since it's still linked to a rare heart defect (Source: WebMD Health)
Source: WebMD Health - August 28, 2013 Category: Consumer Health News Source Type: news

Birth Defects Rare With Antifungal Use (CME/CE)
(MedPage Today) -- Oral fluconazole use during the first trimester of pregnancy was not associated with a significant risk for congenital malformations, a Danish registry study found. (Source: MedPage Today Pediatrics)
Source: MedPage Today Pediatrics - August 28, 2013 Category: Pediatrics Source Type: news

Fluconazole Linked to Increased Risk for Rare Birth DefectFluconazole Linked to Increased Risk for Rare Birth Defect
Taking fluconazole in the first trimester tripled the risk for tetralogy Fallot. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 28, 2013 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health News Source Type: news

Anti-Fungal Drug Not Tied to Most Birth Defects
But experts may still avoid prescribing fluconazole for pregnant women since it's still linked to a rare heart defect Source: HealthDay Related MedlinePlus Pages: Birth Defects, Drug Reactions, Yeast Infections (Source: MedlinePlus Health News)
Source: MedlinePlus Health News - August 28, 2013 Category: Consumer Health News Source Type: news

fluconazole, Diflucan
Title: fluconazole, DiflucanCategory: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 4/4/2013 12:00:00 AM (Source: MedicineNet Hepatitis C General)
Source: MedicineNet Hepatitis C General - April 4, 2013 Category: Infectious Diseases Source Type: news

Rapamune (sirolimus) tablets and oral solution - Pfizer Limited - Revised SPC
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates> SPC Changes Section 4.5 Interaction with other medicinal products and other forms of interaction has been updated to include potential interactions with CYP3A4 inhibitors, which may decrease the metabolism of sirolimus and increase sirolimus blood levels. Such inhibitors include e.g. certain antifungals (e.g. clotrimazole, fluconazole, itraconazole, voriconazole), certain antibiotics (e.g.  troleandomycin, telithromycin, clarithromycin), certain protease inhibitors (e.g. ritonavir, indinavir, boceprevir, telaprevir),  nicardipine, brom...
Source: NeLM - SPC Changes - March 1, 2013 Category: Drugs & Pharmacology Source Type: news

Safety and tolerability of fluconazole in children
Novelli V, Holzel H (Source: The Aspergillus Website - articles)
Source: The Aspergillus Website - articles - February 5, 2013 Category: Respiratory Medicine Source Type: news