Efficacy and safety of oral ibrexafungerp in Chinese patients with vulvovaginal candidiasis: a phase III, randomized, double-blind study
ConclusionsAs a first-in-class antifungal agent, ibrexafungerp demonstrated promising efficacy and favorable safety for VVC treatment in Chinese patients.Chinadrugtrials.org.cn registry numberCTR20220918. (Source: Infection)
Source: Infection - April 3, 2024 Category: Infectious Diseases Source Type: research
Effects of Fluconazole Discontinuation on the Pharmacokinetics of Immunosuppression in Pediatric Heart Transplant Recipients
Purpose: Coccidioidomycosis, also known as Valley Fever, is a fungal infection endemic to the southwest United States and represents a significant risk to immunocompromised individuals living in this region. In accordance with guidelines from the Infectious Diseases Society of America (IDSA), the heart transplant (HTx) program at Phoenix Children ’s recently elected to transition our prophylaxis protocol from lifelong fluconazole (Fluc) to coverage during the first year post-transplant with enhanced surveillance thereafter. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: C. Vo, S. Zangwill, B. Wisotzkey, A. Colon, J. Churosh, A. Kimbro, S. Grohall, Source Type: research
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Molecular Medicine)
Source: Molecular Medicine - March 29, 2024 Category: Molecular Biology Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research
Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain
CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630 (Source: Current Topics in Medicinal Chemistry)
Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research
Hydrazone-containing organotin(IV) complexes: synthesis, characterization, antimicrobial, antioxidant activity and molecular-docking studies
Biometals. 2024 Mar 28. doi: 10.1007/s10534-024-00593-2. Online ahead of print.ABSTRACTThe diorganotin(IV) complexes (5-20) were synthesized in the present research from 4-fluorophenoxyacetic hydrazide and salicylaldehyde derivatives-based hydrazone ligands (1-4) to get an effective biological agent to combat microbial and oxidant deformities. Numerous spectral techniques such as (1H, 13C, 119Sn) NMR, UV-Vis, IR, and mass spectrometry were executed to illuminate the composition of complexes. These techniques ascertained tridentate chelation of hydrazone ligands with tin metal through enolic, phenolic oxygens and imine nitr...
Source: Biometals - March 28, 2024 Category: Biochemistry Authors: Bharti Taxak Jai Devi Binesh Kumar Tanisha Arora Source Type: research
Optimizing fluconazole-embedded transfersomal gel for enhanced antifungal activity and compatibility studies
Fungal infections are of major concern all over the globe, and fluconazole is the most prevalently used drug to treat it. The goal of this research work was to formulate a fluconazole-embedded transfersomal gel for the treatment of fungal infections. A compatibility study between fluconazole and soya lecithin was performed by differential scanning calorimetry (DSC). Transfersomes were formulated by a thin-film hydration technique using soya lecithin and Span 80. A central composite design was adopted to prepare different formulations. Soya lecithin and Span 80 were chosen as independent variables, and the effect of these v...
Source: Frontiers in Pharmacology - March 28, 2024 Category: Drugs & Pharmacology Source Type: research
< em > Capsicum annuum < /em > Oleoresin Nanoemulgel - Design Characterization and < em > In vitro < /em > Investigation of Anticancer and Antimicrobial Activities
CONCLUSION: C. annuum oleoresin and its nanoemulgel can be considered valuable sources for the discovery of new antibacterial, antifungal, and anticancer compounds in the pharmaceutical industry, especially due to their potent activity against various cancer cell lines as well as bacterial and fungal strains.PMID:38532324 | DOI:10.2174/0113816128283684231220062019 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ahmad M Eid Hiba Natsheh Linda Issa Majdulin Zoabi Monia Amer Effat Mahamid Ahmed Mousa Source Type: research
Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: a systematic review of < em > in vitro < /em > studies
In conclusion, the EOs of C. zeylanicum, C. citratus, C. nardus, and M. alternifolia showed antimicrobial activity to reduce biofilm on dental acrylic resin.PMID:38538551 | DOI:10.1080/08927014.2024.2332709 (Source: Biofouling)
Source: Biofouling - March 27, 2024 Category: Molecular Biology Authors: Jo ão Marcos Carvalho-Silva Ana Beatriz Vilela Teixeira Mariana Lima da Costa Valente Marcos Vinicius Wada Shimano Andr éa Cândido Dos Reis Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
