Gallic Acid Derived 1, 2-Diarylindole as a Potential Antifungal Agent against Candida Strain

CONCLUSION: In the present study, 100DL6 (indole derivatives) significantly abrupted the ergosterol biosynthetic pathway and showed moderate anti-candidal effects. These studies suggest that 100DL6 significantly enhances antifungal effect of clinical drug fluconazole synergistically and may be considered as in clinical trial prior to some extensive in-vivo validations.PMID:38549526 | DOI:10.2174/0115680266278892240102045630

Source: Current Topics in Medicinal Chemistry - March 29, 2024 Category: Chemistry Authors: Alka Kurmi Akash Pratap Singh Yashveer Gautam Nandan Singh Alok Tripathi Arvind Singh Negi Hemant K Gautam Anirban Pal Dharmendra Saikia Source Type: research