An unusual 2- < em > O < /em > -glyceryl-glycosyl- γ-pyrone from < em > Erigeron annuus < /em > (L.) with potential antifungal activity: < em > in-vitro < /em > and < em > in-silico < /em > study
Nat Prod Res. 2024 Feb 14:1-11. doi: 10.1080/14786419.2024.2315503. Online ahead of print.ABSTRACTPhytochemical characterisation of the polar fraction of Erigeron annuus extract led to the isolation of glycerylerigeroside (1), a unique γ-pyrone derivative. Structure of 1 was decided by intensive study of NMR and mass spectra as 3-O-[4'-((1,3-dihydroxypropan-2-yl)oxy)-β-D-glucopyranoside)]-4H-pyran-4-one, with uncommon glyceroxy side chain attached to 4' position of pyromeconic acid β-D-glucopyranoside. Antimicrobial potential of 1 was tested against Staphylococcus aureus, Salmonella enterica, and Candida albicans. Compo...
Source: Natural Product Research - February 14, 2024 Category: Biochemistry Authors: Mohamed H Abd El-Razek Ahmed H El-Desoky Abdelhalim A Elgahamy Shaymaa M Bata Tarik A Mohamed Mohamed-Elamir F Hegazy Source Type: research
Widespread dermatophytosis in a healthy adolescent: the first report of multidrug-resistant Trichophyton indotineae infection in the UAE
We describe here the case of a boy with widespread, extremely pruritic, inflammatory dermatophytosis affecting his face, neck, trunk, and extremities, unsuccessfully treated for months with oral terbinafine and fluconazole and a range of topical antimycotics. Qualitative polymerase chain reaction of skin scrapings from his lesions identified a T. interdigitale complex fungus, highly probably T. indotineae due to conspecificity and antifungal resistance. Oral itraconazole, administered over 8 weeks, cleared the infection. Because the patient had not traveled outside the United Arab Emirates for months before the infection b...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - February 13, 2024 Category: Dermatology Authors: Milo š D Pavlović Shireen Marzouk Leis Be ćiri Source Type: research
Mechanisms of antifungal resistance and developments in alternative strategies to combat Candida albicans infection
Arch Microbiol. 2024 Feb 13;206(3):95. doi: 10.1007/s00203-023-03824-1.ABSTRACTCandida albicans is a commensal fungus that infects the humans and becomes an opportunistic pathogen particularly in immuno-compromised patients. Among the Candida genus, yeast C. albicans is the most frequently incriminated species and is responsible for nearly 50-90% of human candidiasis, with vulvovaginal candidiasis alone, affecting about 75% of the women worldwide. One of the significant virulence traits in C. albicans is its tendency to alternate between the yeast and hyphae morphotypes, accounting for the development of multi-drug resista...
Source: Archives of Microbiology - February 13, 2024 Category: Microbiology Authors: Kajal Sharma Prashant Kumar Parmanu Meenakshi Sharma Source Type: research
Widespread dermatophytosis in a healthy adolescent: the first report of multidrug-resistant Trichophyton indotineae infection in the UAE
We describe here the case of a boy with widespread, extremely pruritic, inflammatory dermatophytosis affecting his face, neck, trunk, and extremities, unsuccessfully treated for months with oral terbinafine and fluconazole and a range of topical antimycotics. Qualitative polymerase chain reaction of skin scrapings from his lesions identified a T. interdigitale complex fungus, highly probably T. indotineae due to conspecificity and antifungal resistance. Oral itraconazole, administered over 8 weeks, cleared the infection. Because the patient had not traveled outside the United Arab Emirates for months before the infection b...
Source: Acta Dermatovenerologica Alpina, Panonica, et Adriatica - February 13, 2024 Category: Dermatology Authors: Milo š D Pavlović Shireen Marzouk Leis Be ćiri Source Type: research
