< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
Antimicrobial activity of essential oils against biofilms formed in dental acrylic resin: a systematic review of < em > in vitro < /em > studies
In conclusion, the EOs of C. zeylanicum, C. citratus, C. nardus, and M. alternifolia showed antimicrobial activity to reduce biofilm on dental acrylic resin.PMID:38538551 | DOI:10.1080/08927014.2024.2332709 (Source: Biofouling)
Source: Biofouling - March 27, 2024 Category: Molecular Biology Authors: Jo ão Marcos Carvalho-Silva Ana Beatriz Vilela Teixeira Mariana Lima da Costa Valente Marcos Vinicius Wada Shimano Andr éa Cândido Dos Reis Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
< em > N < /em > -3-Methylbutyl-benzisoselenazol-3(2H)-one Exerts Antifungal Activity In Vitro and in a Mouse Model of Vulvovaginal Candidiasis
Curr Issues Mol Biol. 2024 Mar 14;46(3):2480-2496. doi: 10.3390/cimb46030157.ABSTRACTIn the present work, we evaluated the antifungal activities of two novel ebselen analogs, N-allyl-benzisoselenazol-3(2H)-one (N-allyl-bs) and N-3-methylbutylbenzisoselenazol-3(2H)-one (N-3mb-bs). Colorimetric and turbidity assays were performed to determine the minimum inhibitory concentration (MIC) of these compounds in S1 (fluconazole-sensitive) and S2 (fluconazole-resistant) strains of C. albicans. N-3mb-bs was more active than the N-allyl-bs compound. It is noteworthy that the concentration of N-3mb-bs observed to inhibit fungal growth...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Xiuyi Liang Agata J Pacu ła-Miszewska Richa Vartak Milankumar Prajapati Haiyan Zheng Caifeng Zhao Ganming Mao Ketankumar Patel Natalya U Fedosova Jacek Ścianowski Blase Billack Source Type: research
Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
DiscussionC14R has a potent antifungal activity against a large set of clinical isolates of both C. albicans and C. auris, showing its capacity to disrupt Candida membranes. This antifungal activity remains consistent across isolates regardless of their clinical source. Furthermore, the absence of correlation between MICs to C14R and resistance to fluconazole indicates the peptide’s potential effectiveness against fluconazole-resistant strains. Our results suggest the potential of C14R, a pore-forming peptide, as a treatment option for fungal infections, such as invasive candidiasis, including fluconazole and amphoterici...
Source: Frontiers in cellular and infection microbiology - March 27, 2024 Category: Microbiology Source Type: research
Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo
J Inorg Biochem. 2024 Mar 12;255:112522. doi: 10.1016/j.jinorgbio.2024.112522. Online ahead of print.ABSTRACTWith the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)2 (bpm)] (PF6)2 (N-N = 2,2'-bipyridine) (bpy, in Ru1), 1,10-phenanthroline (phen, i...
Source: Journal of Inorganic Biochemistry - March 24, 2024 Category: Biochemistry Authors: Zhi-Chang Xu Xiu-Rong Ma Li-Juan Zhang Hui-Ting Chen Ding-Mei Qing Rong-Tao Li Rui-Rong Ye Rui-Rui Wang Source Type: research
Antifungal activity of ruthenium (II) complex combined with fluconazole against drug-resistant Candida albicans in vitro and its anti-invasive infection in vivo
J Inorg Biochem. 2024 Mar 12;255:112522. doi: 10.1016/j.jinorgbio.2024.112522. Online ahead of print.ABSTRACTWith the abuse of antibiotics and azoles, drug-resistant Candida albicans infections have increased sharply and are spreading rapidly, thereby significantly reducing the antifungal efficacy of existing therapeutics. Several patients die of fungal infections every year. Therefore, there is an urgent requirement to develop new drugs. Accordingly, we synthesized a series of polypyridyl ruthenium (II) complexes having the formula [Ru (NN)2 (bpm)] (PF6)2 (N-N = 2,2'-bipyridine) (bpy, in Ru1), 1,10-phenanthroline (phen, i...
Source: Journal of Inorganic Biochemistry - March 24, 2024 Category: Biochemistry Authors: Zhi-Chang Xu Xiu-Rong Ma Li-Juan Zhang Hui-Ting Chen Ding-Mei Qing Rong-Tao Li Rui-Rong Ye Rui-Rui Wang Source Type: research
Pharmacology and pharmacokinetics of tazemetostat
AbstractTazemetostat, a novel oral selective inhibitor of enhancer of zeste homolog 2 (EZH2), was approved by the Food and Drug Administration (FDA) in 2020 for use in patients with advanced epithelioid sarcoma or relapsed/refractory (R/R) EZH2-mutated follicular lymphoma. These indications were approved by the FDA trough accelerated approval based on objective response rate and duration of response that resulted from phase 2 clinical trials. Tazemetostat competes with S-adenosylmethionine (SAM) cofactor to inhibit EZH2, reducing the levels of trimethylated lysine 27 of histone 3 (H3K27me3), considered as pharmacodynamic m...
Source: Cancer Chemotherapy and Pharmacology - March 23, 2024 Category: Cancer & Oncology Source Type: research
Anti-fungal effects of novel N-(tert-butyl)-2-(pyridin-2-yl)imidazo[1,2-a]pyridin-3-amine derivative and it's in-vitro, in-silico, and mode of action against Candida spp
In this study, two newly synthesized imidazo[1,2-a]pyridine derivative (Probe I and Probe II) molecules were investigated for its antimicrobial potency against of a panel of bacterial (Gram-positive and Gram-negative bacteria) and fungal pathogens. Among the different types of pathogens, we found that Probe II showed excellent antifungal activity against fungal pathogens, based on the preliminary screening the potent molecule further investigated against multidrug-resistance Candida sp. (n = 10) and compared with commercial molecules. In addition, in-silico molecular docking, its dynamics, absorption, distribution, metabol...
Source: Archives of Microbiology - March 21, 2024 Category: Microbiology Authors: Manivannan Nandhagopal Ramanjaneyulu Mala Kanagasabai Somarathinam Divya Dhakshinamurthy Mathivanan Narayanasamy Priyadharshni Vijayan Manimuthu Mani Shankar Source Type: research
