Eating Disorders & Weight Management Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Risks of suboptimal and excessive thyroid hormone replacement across ages
ConclusionSuboptimal and excessive LT4 replacement of the preventable non-communicable disease hypothyroidism requires more focus from the healthcare system and from the global political systems to prevent the personally devastating and socioeconomically challenging consequences. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research

Clustering of gout-related comorbidities and their relationship with gout flares: a data-driven cluster analysis of eight comorbidities
ConclusionsWe clustered people with gout into five groups with varying comorbidities. People with CVD, CKD, and cancer had the highest risk of gout flares and should receive comprehensive care. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research

Endocannabinoid-related molecules predict the metabolic efficacy of GLP-1 receptor agonism in humans with obesity
ConclusionsOur data suggests that specific NAEs such as OEA and AEA are promising biomarkers of GLP-1RA metabolic efficacy in humans with obesity during weight loss maintenance. Plasma profiling of EC-related molecules may be a promising strategy to tailor GLP-1R-based therapies to individual needs in obesity and diabetes management. (Source: Journal of Endocrinological Investigation)
Source: Journal of Endocrinological Investigation - May 1, 2024 Category: Endocrinology Source Type: research

Thyroid function and iodine intake: global recommendations and relevant dietary trends
Nature Reviews Endocrinology, Published online: 01 May 2024; doi:10.1038/s41574-024-00983-zThis Review discusses the importance of adequate iodine intake for thyroid function, outlining the varying global intake recommendations. Iodine is also considered in the context of the increasing prevalence of overweight and obesity, as well as dietary trends such as cardioprotective salt restriction and plant-based diets. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - May 1, 2024 Category: Endocrinology Authors: Sarah C. Bath Source Type: research

Is the QCI framework suited for monitoring outcomes and costs in a teaching hospital using value-based healthcare principles? A retrospective cohort study
Conclusions The QCI framework is effective for monitoring changes in average total costs and relevant health outcomes on an institutional level. Health outcomes are associated with hospital-based costs of care. (Source: BMJ Open)
Source: BMJ Open - May 1, 2024 Category: General Medicine Authors: van Veghel, W., van Dijk, S. C., Klem, T. M., Weel, A. E., Bügel, J.-B., Birnie, E. Tags: Open access, Health economics Source Type: research

Seipin Deficiency Leads to Energy Dyshomeostasis via Inducing Hypothalamic Neuroinflammation and Aberrant Expression of Neuropeptides
AbstractSeipin is a key regulator of lipid metabolism, the deficiency of which leads to severe lipodystrophy. Hypothalamus is the pivotal center of brain that modulates appetite and energy homeostasis, where Seipin is abundantly expressed. Whether and how Seipin deficiency leads to systemic metabolic disorders via hypothalamus-involved energy metabolism dysregulation remains to be elucidated. In the present study, we demonstrated that Seipin-deficiency induced hypothalamic inflammation, reduction of anorexigenic pro-opiomelanocortin (POMC), and elevation of orexigenic agonist-related peptide (AgRP). Importantly, administra...
Source: NeuroMolecular Medicine - May 1, 2024 Category: Neurology Source Type: research

Effect of metformin and lifestyle intervention on adipokines and hormones in breast cancer survivors: a pooled analysis from two randomized controlled trials
ConclusionsSupportive healthy lifestyle programs combined with metformin to achieve maximal risk reduction among BC cancer survivors are recommended, especially for those with obesity in menopause. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - May 1, 2024 Category: Cancer & Oncology Source Type: research

Factors that determine patients considering medication for the disease of obesity: an IMI2 SOPHIA study
International Journal of Obesity, Published online: 01 May 2024; doi:10.1038/s41366-024-01524-4Factors that determine patients considering medication for the disease of obesity: an IMI2 SOPHIA study (Source: International Journal of Obesity)
Source: International Journal of Obesity - May 1, 2024 Category: Eating Disorders & Weight Management Authors: H. C. Craig D. Alsaeed H. Heneghan W. Al-Najim E. Al Ozairi C. W. le Roux Source Type: research

Shedding the weight of exercise for obesity management
International Journal of Obesity, Published online: 01 May 2024; doi:10.1038/s41366-024-01527-1Shedding the weight of exercise for obesity management (Source: International Journal of Obesity)
Source: International Journal of Obesity - May 1, 2024 Category: Eating Disorders & Weight Management Authors: Gaurav Kudchadkar Oluwatosin Akinsiku Marleigh Hefner Princess Uchechi Ozioma Holli Booe Nikhil V. Dhurandhar Source Type: research

Improving Kidney Transplant Rates in Obese CKD Patients by Sleeve Gastrectomy
Obesity is a central obstacle to health and wellness in people with chronic kidney disease (CKD). It is linked to progression of CKD, a greater burden of disease and disability, and reduced access to kidney transplant.1-3 Moreover, obesity is a common condition in CKD, being seen in nearly 50% of individuals with CKD stages 3 and 4.4 As a highly prevalent and major risk factor for adverse outcomes, obesity has been receiving increasing attention from the nephrology community as an urgent problem that needs addressing. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - May 1, 2024 Category: Internal Medicine Authors: Allon N. Friedman Tags: Editorial Source Type: research

Weight Loss Surgery Increases Kidney Transplant Rates in Patients With Renal Failure and Obesity
To describe the outcomes of kidney transplant (KT) candidates with obesity undergoing sleeve gastrectomy (SG) to meet the criteria for KT. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - May 1, 2024 Category: Internal Medicine Authors: Aleksandra Kukla, Sukhdeep S. Sahi, Pavel Navratil, Roberto P. Benzo, Byron H. Smith, Dustin Duffy, Walter D. Park, Meera Shah, Pankaj Shah, Matthew M. Clark, David C. Fipps, Aleksandar Denic, Carrie A. Schinstock, Patrick G. Dean, Mark D. Stegall, Yogish Tags: Original article Source Type: research

High-fat diet as a predisposing factor to Parkinson disease via interplay between inflammation and autophagy in a murine model
Background: The underlying mechanisms of the neuronal degeneration in Parkinson ’s Disease (PD) are not well understood, but mitochondrial dysfunction, chronic inflammation and defective autophagy have been implicated in animal models of PD. Several studies indicated that among factors associated with risk of developing PD, dietary habits have an important role. High-fat diet (HFD) is associated with an increased risk of developing neurodisorders and that seems to be related to obesity-induced inflammation. (Source: Parkinsonism and Related Disorders)
Source: Parkinsonism and Related Disorders - May 1, 2024 Category: Neurology Authors: A.L. J úlio de Souza, A. Signor, R. Colucci Source Type: research

Are Poor Outcomes Always a Surgeon's Complication?
Many lectures I hear on the regional and national level focus on complications, failures, and risk factors in oral and maxillofacial surgery. However, as I look at my own cases and the presented cases, there is sometimes, and often, an underlying cause. Poor host responses, such as systemic medical conditions, local disease or inflammation, or unhealthy habits, can all contribute to increased complication rates. For example, it is well documented that diabetics have increased wound infections, dehiscence, and scarring, and coupled with obesity, the risk for postoperative infections is further increased. (Source: Journal of...
Source: Journal of Oral and Maxillofacial Surgery - May 1, 2024 Category: ENT & OMF Authors: Tara Aghaloo Tags: Editorial Source Type: research

Effect of the Healthy Dish Method to Reduce Waist Circumference in Teachers with Abdominal Obesity of a Peruvian University
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - April 30, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research

MCU genetically altered mice suggest how mitochondrial Ca < sup > 2+ < /sup > regulates metabolism
Trends Endocrinol Metab. 2024 Apr 29:S1043-2760(24)00088-2. doi: 10.1016/j.tem.2024.04.005. Online ahead of print.ABSTRACTSkeletal muscle has a major impact on total body metabolism and obesity, and is characterized by dynamic regulation of substrate utilization. While it is accepted that acute increases in mitochondrial matrix Ca2+ increase carbohydrate usage to augment ATP production, recent studies in mice with deleted genes for components of the mitochondrial Ca2+ uniporter (MCU) complex have suggested a more complicated regulatory scenario. Indeed, mice with a deleted Mcu gene in muscle, which lack acute mitochondrial...
Source: Trends in Endocrinology and Metabolism: TEM - April 30, 2024 Category: Endocrinology Authors: Jiuzhou Huo Jeffery D Molkentin Source Type: research