Eating Disorders & Weight Management Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Social inequality in prevalence of NCD risk factors: a cross-sectional analysis from the population-based Tromso Study 2015-2016
Conclusion We found statistically significant educational gradients in women and men for all WHO-established leading NCD risk factors within a Nordic middle-aged to older general population. The prevalence of all risk factors increased at lower educational levels, except for harmful alcohol use, which increased at higher educational levels. (Source: BMJ Open)
Source: BMJ Open - April 30, 2024 Category: General Medicine Authors: Hetland, R. A., Wilsgaard, T., Hopstock, L. A., Ariansen, I., Johansson, J., Jacobsen, B. K., Grimsgaard, S. Tags: Open access, Epidemiology Source Type: research

Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial
Volume 16, Issue 1, January-December 2024 . (Source: Gut Microbes)
Source: Gut Microbes - April 30, 2024 Category: Microbiology Authors: Zhengxiao ZhangValentin MocanuEdward C. DeehanNaomi HotteYuanyuan ZhuShanshan WeiDina H. KaoShahzeer KarmaliDaniel W. BirchJens WalterKaren L. Madsena College of Ocean Food and Biological Engineering, Fujian Provincial Engineering Technology Research Cent Source Type: research

Associations Between Prenatal Exposure to Maternal Diabetes and Obesity and Newborn Subcortical Volumes
Maternal diabetes (MD) and maternal obesity (MO) during pregnancy are risk factors for early life adiposity, but the underlying neurobiological mechanisms are undefined. We aim to study the relationships between prenatal exposure to MD and MO and newborn subcortical volumes, and moderating effects of sex. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Shan Luo, Ann Alex, Jerod Rasmussen, Jetro J. Tuulari, Julie Sigur ðardottir, Claudia Buss, Kirsten A. Donald, David Edwards, John Gilmore, Hasse Karlsson, Dan J. Stein, Martin Styner, Gustavo de los Campos, Paul M. Thompson, Rebecca Knickmeyer, ENIGMA-O Source Type: research

Adipose Tissue-Brain Interactions Modulate an Anorexia-Related Phenotype in Mice
Anorexia nervosa (AN) is characterized by hypophagia, low body weight, and compulsive exercise. The activity-based anorexia (ABA) paradigm induces aspects of AN in rodents. We tested whether transplanting adipose tissue from high fat diet-fed obese mice into normal weight recipient mice would attenuate ABA in recipients. We also assessed whether the effects of transplanted obese fat depend upon hypothalamic AgRP neurons. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Dongmin Yoon, Zhang Jie, Rizaldy Zapata, Imran Kyeso, Eeshi Uppalapati, Stephanie Dulawa Tags: SYMPOSIUM Source Type: research

Understanding Structural Brain Alterations in Anorexia Nervosa: A Multimodal Investigation of Morphometry, Magnetic Resonance Spectroscopy and Blood-Based Biomarkers
The acute state of anorexia nervosa (AN) is associated with widespread reductions in cortical gray matter (GM) thickness and white matter (WM) volume, suspected changes in myelin content and elevated levels of the neuronal damage marker neurofilament light (NF-L), but the underlying mechanisms remain unclear. To gain a better understanding of brain changes in AN, we applied a multimodal approach combining advanced neuroimaging methods with analysis of blood-derived biomarkers. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Stefan Ehrlich, Arne Doose, Alexander P. Lin Source Type: research

Excitatory Neuromodulation Enhances Perceptual Modification When Viewing Self-Images in Body Dysmorphic Disorder
Individuals with body dysmorphic disorder (BDD) experience distorted perception of appearance, a phenotype that overlaps with anorexia nervosa. This may be attributed to an imbalance in global vs. local visual processing. Short-duration viewing allows global/holistic but not local/detailed visual processing. In this proof-of-concept study, we investigated if short-duration face presentation changes dorsal or ventral visual system neural connectivity in BDD and if the effect is enhanced by applying intermittent theta-burst stimulation (iTBS) to the dorsal visual stream. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Wan-Wa Wong, Rangaprakash Deshpande, Reza Tadayon-Nejad, Joel Diaz, Andrew Leuchter, Gerhard Hellemann, Jamie Feusner Source Type: research

Using Neural Biotypes to Predict Future Symptom Expression in Adolescent Eating Disorders
Eating disorders (ED) are among the most debilitating and medically dangerous psychiatric disorders affecting adolescents. Overlapping symptoms, along with diagnostic crossover, suggest heterogeneity is not well captured by current diagnostic approaches, which may undermine treatment. Although trait-based phenotypes (over-control, under-control) show promise identifying clinically meaningful groups reflecting core ED features, defining ED syndromes biologically may better predict symptoms and clinical outcomes. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Christina Wierenga, Christine Fennema-Notestine, Amanda Bischoff-Grethe Source Type: research

Epigenome-Wide Association Studies Identify Biological Mechanisms and Genes Conferring Vulnerability to Mental Illness in Adolescence
Adolescence is a developmentally sensitive period, and the age of onset for common mental disorders such as depression, anxiety and eating disorders. DNA methylation (DNAm), which is modulated by developmental, environmental, and genetic factors, may offer a unique opportunity to discover early biomarkers for such disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sylvane Desrivieres, Xinyang Yu, ENIGMA-Epigenetics Working Group ENIGMA Consortium Tags: SYMPOSIUM Source Type: research

Persistent Parietal Alterations After Partial Weight Restoration in Children With an Early-Onset Form of Anorexia Nervosa
Anorexia nervosa (AN) typically starts during adolescence and has one of the highest mortality rates of all psychiatric disorders. The early-onset form of AN ( (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Clara Moreau, Anael Ayrolles, Robin Bonicel, Coline Stordeur, Stefan Ehrlich, Paul M. Thompson, Thomas Bourgeron, Richard Delorme Source Type: research

397. Assessing the Potential Role of Platelets in Metabolic Syndrome-Related Cognitive Impairment in Veterans With Schizophrenia
Schizophrenia is associated with progressive cognitive decline. Metabolic syndrome (MetS) —characterized by truncal obesity, insulin resistance, dyslipidemia and hypertension—is highly prevalent in individuals with schizophrenia and has been associated with cognitive impairment, but the underlying mechanism is not known. We sought to determine whether Veterans with schizophrenia como rbid with MetS (relative to those without MetS) have: 1) worse cognition; 2) higher level of platelet activation, and 3) whether platelet activation is negatively correlated with cognitive function. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Olaoluwa Okusaga, Vinod Vijayan, Rolando Rumbaut Source Type: research

353. Methylation of CRHR1 and CRHR2 is Associated With Lifetime Adversity, HPA-Axis Signaling Changes, and Obesity
Lifetime stress can alter HPA-axis signaling, and chronic changes in HPA-axis signaling is known to be related to health outcomes. DNA methylation has been proposed as one mechanism through which chronic stress may cause physiologic changes. Here, we examine whether lifetime stress is related to methylation at HPA-related genes, and whether methylation at these sites is associated with BMI. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Zachary Harvanek, Xinyu Zhang, Ke Xu, Rajita Sinha Source Type: research

323. Evidence of dACC Glutamate Modulation During Top-Down Inhibitory Control Predicting Weight Loss Ability in Individuals With Obesity Using 1H fMRS
Poor top-down inhibitory control and its association to weight loss maintenance is poorly understood. The dorsal anterior cingulate cortex (dACC) is central to inhibitory control that is driven by the interplay of glutamatergic/GABAergic neurotransmission. 1H fMRS can assess changes in glutamate driven by task condition, illuminating neurobiological mechanisms. Here, we present preliminary evidence of dACC glutamate modulation being impacted by emotionally valanced food cues during inhibitory control and its association with weight loss ability in individuals with obesity. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Jillian Eichstaedt, Rachel Sochocki, Dalal Khatib, Nicole Miller, Vaibhav Diwadkar, Paul Burghardt, Amy Rothberg, Jeffrey Stanley Source Type: research

275. Plasma Levels of FGF21 and GDF15 are Elevated in Patients With Bipolar and Treatment-Resistant Depression
Fibroblast-Growth-Factor 21 (FGF21) and Growth-Differentiation-Factor 15 (GDF15) have emerged as potential biomolecules of interest in mood disorders, particularly treatment-resistant depression (TRD) and bipolar disorder (BD). FGF21, known for metabolic regulation in conditions like obesity and diabetes, is now being explored for its role in mood disorders. GDF15, a multifaceted protein involved in cellular functions, has implications in stress response and inflammation, both relevant to mood disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Francisco Cruz Avi ña, Francisco da Silva, Rafaela C. Cordeiro, Bashar Asir, Giovana Zunta-Soares, Jair Soares, Giselli Scaini, Joao Quevedo Source Type: research

319. Effects of Exercise and Diet Interventions on Delay Discounting Behavior and Neurobiology in Adults With Overweight/Obesity
This study investigated effects of exercise and diet interventions on impulse-related behaviors as measured by delay discounting (DD) and related neurobiology in adults with overweight/obesity. We hypothesized that exercise, compared to diet, would be associated with reduced DD propensity (k-value) and greater activity in bilateral anterior insulae (AI), medial prefrontal cortex (mPFC), and anterior cingulate cortex (ACC) in response to a meal (i.e., change between fasted and fed states [fasted-fed]). (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Kelly Cosgrove, Jason Tregellas, Marc-Andre Cornier, Maureen McHugo, Keith Dodd, Edward Melanson, Allison Hild, Kristina Legget Source Type: research

322. Feeling Rejected? Hypersensitivity in Both Anorexia Nervosa and Bulimia Nervosa
Anorexia nervosa and bulimia nervosa are both eating disorders associated with a strong desire to alter one ’s body to meet social expectations. Altered neural processing of social information may contribute to the development and maintenance of both eating disorders. (Source: Biological Psychiatry)
Source: Biological Psychiatry - April 29, 2024 Category: Psychiatry Authors: Sarah Gibson, Yi Luo, Jayme Palka, Carrie McAdams Source Type: research