323. Evidence of dACC Glutamate Modulation During Top-Down Inhibitory Control Predicting Weight Loss Ability in Individuals With Obesity Using 1H fMRS

Poor top-down inhibitory control and its association to weight loss maintenance is poorly understood. The dorsal anterior cingulate cortex (dACC) is central to inhibitory control that is driven by the interplay of glutamatergic/GABAergic neurotransmission. 1H fMRS can assess changes in glutamate driven by task condition, illuminating neurobiological mechanisms. Here, we present preliminary evidence of dACC glutamate modulation being impacted by emotionally valanced food cues during inhibitory control and its association with weight loss ability in individuals with obesity.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research