397. Assessing the Potential Role of Platelets in Metabolic Syndrome-Related Cognitive Impairment in Veterans With Schizophrenia

Schizophrenia is associated with progressive cognitive decline. Metabolic syndrome (MetS) —characterized by truncal obesity, insulin resistance, dyslipidemia and hypertension—is highly prevalent in individuals with schizophrenia and has been associated with cognitive impairment, but the underlying mechanism is not known. We sought to determine whether Veterans with schizophrenia como rbid with MetS (relative to those without MetS) have: 1) worse cognition; 2) higher level of platelet activation, and 3) whether platelet activation is negatively correlated with cognitive function.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research