Adipose Tissue-Brain Interactions Modulate an Anorexia-Related Phenotype in Mice

Anorexia nervosa (AN) is characterized by hypophagia, low body weight, and compulsive exercise. The activity-based anorexia (ABA) paradigm induces aspects of AN in rodents. We tested whether transplanting adipose tissue from high fat diet-fed obese mice into normal weight recipient mice would attenuate ABA in recipients. We also assessed whether the effects of transplanted obese fat depend upon hypothalamic AgRP neurons.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: SYMPOSIUM Source Type: research