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Ozempic And Other Weight Loss Drugs Will Only Work With Digital Health
Weight loss injections are now widely used as miracle drugs for effortless skinniness. But without digital health, they just won’t work in the long run. The U.S. Food and Drug Administration, the FDA, approved Wegovy, a semaglutide injection for chronic weight management in adults with obesity or overweight with at least one weight-related condition for use in addition to a reduced calorie diet and increased physical activity in 2021.  Semaglutide was originally used for the treatment of type 2 diabetes, and was found to have a major lucky side effect: being very effective in assisting weight loss. Semaglutide inject...
Source: The Medical Futurist - April 23, 2024 Category: Information Technology Authors: Andrea Koncz Tags: Digital Health Research weight management weight loss Ozempic Wagevy Source Type: blogs

Fight Aging! Newsletter, April 22nd 2024
This study reveals a potential treatment for human mitochondrial diseases. « Back to Top A Population Study Correlates Air Pollution with Faster Cognitive Aging https://www.fightaging.org/archives/2024/04/a-population-study-correlates-air-pollution-with-faster-cognitive-aging/ A number of large epidemiological studies provide evidence for long-term exposure to greater levels of air pollution to accelerate the onset and progression of age-related disease. A few of these manage to control for the tendency for wealthier people to avoid living in areas with higher particulate air pollution, ...
Source: Fight Aging! - April 21, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The Effect Being Called ‘ Fat ’ Has On 10-Year-Old Girls, 9 Years Later (M)
The startling connection between childhood labels and adult obesity. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - April 20, 2024 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss subscribers-only Source Type: blogs

An Interview with Reason of Repair Biotechnologies on Reversal of Atherosclerosis
As some of you may know, I co-founded Repair Biotechnologies with Bill Cherman. The company is presently on the development of a gene therapy approach now demonstrated to rapidly reverse atherosclerosis in mice, the condition in which fatty plaques grow to narrow blood vessels and weaken blood vessel walls. One of the possible approaches to treating aging as a medical condition is to take the list of causes of human mortality, start at the top, and work down. Atherosclerosis is the single largest cause of death in our species, through the rupture of unstable atherosclerotic plaque leading to heart attack or stroke. The bur...
Source: Fight Aging! - April 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

GLP-1 medications like Wegovy are effective metabolic health tools for teens with insulin resistance
Lizzie is a 13-year-old with a great sense of humor. She tells it like it is, especially to her Mom, Jackie, who admits to being a bit of an Almond Mom (the parent who is stuck in a weight-focused diet culture). Jackie leads a very healthy lifestyle and has never had to deal with being Read more… GLP-1 medications like Wegovy are effective metabolic health tools for teens with insulin resistance originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 17, 2024 Category: General Medicine Authors: Tags: Meds Obesity Pediatrics Source Type: blogs

Embracing imperfection: strategies for growth and self-compassion [PODCAST]
Subscribe to The Podcast by KevinMD. Watch on YouTube. Catch up on old episodes! Join Caissa Troutman, an obesity medicine physician, as we delve into the intricate relationship between self-perception, mistakes, and personal growth. Caissa shares insights on how our beliefs about perfectionism shape our reactions to failure and explores the transformative power of self-compassion Read more… Embracing imperfection: strategies for growth and self-compassion [PODCAST] originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 16, 2024 Category: General Medicine Authors: Tags: Podcast Psychiatry Source Type: blogs

Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

TLR2 Important in the Dysfunction of Hair Follicles
Dysfunction in hair follicles and loss of the capacity for hair growth is a perhaps surprisingly complex aspect of aging and disease. For all the the basic mechanisms of hair growth are well-investigated, the hair follicle is a complex structure, and hair growth involves the collaboration of many cell types, activities, and signaling that shifts over time as the follicle progresses through the stages of growth. It has proven to be hard to pin down any one specific mechanism as vital, and it may turn out to be the case that no one specific mechanism is the key to preventing loss of hair with advancing age and other circumst...
Source: Fight Aging! - April 12, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Lilly's Carelessness in Discontinuing 3 mL vials of Humalog Causes Shortages in 10 mL vials of Humalog + Unbranded Lispro
Last week, the JDRF shared newshttps://x.com/JDRF/status/1770848177354137650 in a series of three Tweets about how Eli Lilly& Company, Inc. was reporting that 10 mL vials of Humalog and the company ' s identical, unbranded (meaning Lilly sells it using the generic drug name rather than brand-name Humalog) version of Humalog known as Lilly Insulin Lispro Injection could be facing temporary lack of availability in selected locations around the country. Lilly tried to reassure everyone that it was only a temporary issue. But while Lilly complains it cannot keep up with demand for Mounjaro/Zepbound, it is having its own su...
Source: Scott's Web Log - April 9, 2024 Category: Endocrinology Tags: Eli Lilly and Company 2024 Humalog lispro vials Source Type: blogs

Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls. Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Costco Weight-Loss Program: Omission of Critical Data Puts Patients at (Financial) Risk
This week, the world learned that Costco Wholesale would start selling Novo Nordisk ' s newest, but vastly overpriced GLP-1 inhibitor medicine known generically as semaglutide (sold under the brand names Ozempic and Rybelsus for Type 2 diabetes, and under the brand name of Wegovy for weight-loss for those with obesity without Type 2 diabetes). We learned of the Costco GLP-1 initiative from a press release from Costco ' s strategic partner known as Sesamehttps://sesamecare.com/ which is the entity which will connect patients with its network of thousands of outpatient healthcare providers nationwide who are more than w...
Source: Scott's Web Log - April 3, 2024 Category: Endocrinology Tags: 2024 biosimilars Costco GLP-1 inhibitor liraglutide semaglutide Sesame Source Type: blogs

Efferocytosis in the Context of Aging and Age-Related Disease
There is something of a tradition in the aging research community of writing reviews that attempt to summarize everything that is known of a single specific cellular behavior in the context of the panoply of cell and tissue dysfunction observed in aging. Today it is the turn of efferocytosis, the clearance of dying cells and their immediate debris by phagocytes such as macrophages of the innate immune system. It is fairly straightforward to mount an argument to suggest that more efficient efferocytosis is a good thing, as unwanted consequences attend the presence of lingering cell corpses cluttering up tissue. Like autopha...
Source: Fight Aging! - April 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes. « Back to Top A Skeptical View of the Role of Nuclear DNA Damage in Aging https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/ It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

AusHealthIT Poll Number 740 – Results – 31 March, 2024.
Here are the results of the recent poll. Is Australia Doing Enough To Manage The Rising Epidemic Of Obesity? Yes                                                (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - March 31, 2024 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

The battle of the bulge: The struggle is real
The economic impact of obesity looms large, casting a shadow over both individual well-being and national prosperity. Beyond the personal struggles and societal pressures surrounding weight management, the financial ramifications of obesity ripple through health care systems, labor markets, and various sectors of the economy. In the United States alone, the annual health care costs Read more… The battle of the bulge: The struggle is real originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 30, 2024 Category: General Medicine Authors: Tags: Conditions Obesity Source Type: blogs