Blunt Abdominal Trauma in Pregnancy: Higher Rates of Severe Abdominal Injuries
DISCUSSION: BSOI occurred at a lower rate in PTPs compared to non-PTPs; however, contrary to the "cushion effect" observed in obese populations, pregnant women had a higher rate of severe abdominal injuries. These data support comprehensive evaluations for PTPs presenting after a MVC.LEVEL OF EVIDENCE: IV (therapeutic).PMID:38676625 | DOI:10.1177/00031348241248790 (Source: The American Surgeon)
Source: The American Surgeon - April 27, 2024 Category: Surgery Authors: Shannon Skochko Jeffry Nahmias Michael Lekawa Allen Kong Sebastian Schubl Lourdes Swentek Areg Grigorian Source Type: research

Descriptive Analysis of Outcomes After Onlay Ventral Hernia Repair in Obese Patients
CONCLUSION: Obesity is a risk factor for poor outcomes after VHR. We developed a protocol for obese patients with large defects involving a modified onlay technique which demonstrates comparable results to other VHR techniques in obese patients.PMID:38676337 | DOI:10.1177/00031348241241706 (Source: The American Surgeon)
Source: The American Surgeon - April 27, 2024 Category: Surgery Authors: Carolyn P Smullin Rivfka S Shenoy Kevin J Blair Charles F Chandler Source Type: research

Phytochemicals, Herbal Extracts, and Dietary Supplements for Metabolic Disease Management
Endocr Metab Immune Disord Drug Targets. 2024 Apr 26. doi: 10.2174/0118715303287911240409055710. Online ahead of print.ABSTRACTComprehensive and effective care techniques have become essential due to the global epidemic dimensions of metabolic disorders, including diabetes, obesity, and cardiovascular ailments. Recent research highlights the potential of dietary supplements, herbal extracts, and phytochemicals in treating metabolic diseases. This abstract conveys the current state of the science in this field by highlighting these findings' underlying mechanisms and potential therapeutic applications. Plant-based diets con...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Praveen Halagali Aparna Inamdar Jagroop Singh Amit Anand Poulami Sadhu Rashmi Pathak Himanshu Sharma Deepak Biswas Source Type: research

Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research

Impaired Fibroblast Growth Factor 21 (FGF21) Associated with Visceral Adiposity Leads to Insulin Resistance: The Core Defect in Diabetes Mellitus
Curr Diabetes Rev. 2024 Apr 26. doi: 10.2174/0115733998265915231116043813. Online ahead of print.ABSTRACTThe Central nervous system (CNS) is the prime regulator of signaling pathways whose function includes regulation of food intake (consumption), energy expenditure, and other metabolic responses like glycolysis, gluconeogenesis, fatty acid oxidation, and thermogenesis that have been implicated in chronic inflammatory disorders. Type 2 diabetes mellitus (T2DM) and obesity are two metabolic disorders that are linked together and have become an epidemic worldwide, thus raising significant public health concerns. Fibroblast g...
Source: Current Diabetes Reviews - April 27, 2024 Category: Endocrinology Authors: Unnati Jain Priyanka Srivastava Ashwani Sharma Subrata Sinha Surabhi Johari Source Type: research