Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis
World J Gastroenterol. 2024 Feb 28;30(8):811-816. doi: 10.3748/wjg.v30.i8.811.ABSTRACTEndoscopic ultrasound (EUS) with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and autoimmune pancreatitis or to analyze cyst fluid. The most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis, which is likely induced by the same pathophysiological mechanisms as after endoscopic retrograde cholangiopancreatography (ERCP). According to the current European Society of Gastrointestinal Endoscopy guideline, nonsteroidal a...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Mike de Jong Foke van Delft Christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Source Type: research
Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis
World J Gastroenterol. 2024 Feb 28;30(8):811-816. doi: 10.3748/wjg.v30.i8.811.ABSTRACTEndoscopic ultrasound (EUS) with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and autoimmune pancreatitis or to analyze cyst fluid. The most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis, which is likely induced by the same pathophysiological mechanisms as after endoscopic retrograde cholangiopancreatography (ERCP). According to the current European Society of Gastrointestinal Endoscopy guideline, nonsteroidal a...
Source: World Journal of Gastroenterology : WJG - March 22, 2024 Category: Gastroenterology Authors: Mike de Jong Foke van Delft Christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Source Type: research
Nonsteroidal anti-inflammatory drugs before endoscopic ultrasound guided tissue acquisition to reduce the incidence of post procedural pancreatitis
World J Gastroenterol. 2024 Feb 28;30(8):811-816. doi: 10.3748/wjg.v30.i8.811.ABSTRACTEndoscopic ultrasound (EUS) with fine needle aspiration or fine needle biopsy is the gold standard for sampling tissue to diagnose pancreatic cancer and autoimmune pancreatitis or to analyze cyst fluid. The most common reported adverse event of fine needle aspiration and/or fine needle biopsy is acute pancreatitis, which is likely induced by the same pathophysiological mechanisms as after endoscopic retrograde cholangiopancreatography (ERCP). According to the current European Society of Gastrointestinal Endoscopy guideline, nonsteroidal a...
Source: World Journal of Gastroenterology - March 22, 2024 Category: Gastroenterology Authors: Mike de Jong Foke van Delft Christine Roozen Erwin-Jan van Geenen Tanya Bisseling Peter Siersema Marco Bruno Source Type: research
Characterization of Diclofenac-induced Renal Damage in Normotensive
and Hypertensive Rats: A Comparative Analysis
Conclusions The data presented herein demonstrated that diclofenac induces
renal damage and impaired renal function in both NTR and SHR, but those effects
are exacerbated in SHR, as seen by the histological changes and electrolytes
balance disturbance, therefore, reinforcing that diclofenac may increase the
risks of cardiovascular events in hypertensive patients. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 19, 2024 Category: Drugs & Pharmacology Authors: Boeing, Thaise Lima, Alana Bittencourt F. Busana, Maria Eduarda Mariano, Lu ísa Nathália Bolda da Silva, Luisa Mota Silva, Rita de C ássia Vilhena da de Souza, Priscila Tags: Original Article Source Type: research
Systematic review of randomized controlled trials of topicals for actinic keratosis field therapy
This study aims to systematically review randomized controlled trials on topical treatments for actinic keratosis field cancerization, following the PRISMA guidelines. Clinical recommendations were based on the Oxford Centre for Evidence-Based Medicine. We identified 20 original randomized controlled trials for topical cutaneous field therapy. 0.5% 5-Fluorouracil/salicylic acid and 0.5% 5-fluorouracil received a clinical recommendation grade of A, while diclofenac sodium received a clinical recommendation grade of B. Calcipotriol/5-fluorouracil, Imiquimod, sunscreen combination therapies, and tirbanibulin received a recomm...
Source: Cell Research - March 18, 2024 Category: Cytology Authors: Paras Patel Jennifer Wang David Bitterman Jessica Mineroff Evan Austin Jared Jagdeo Source Type: research
Systematic review of randomized controlled trials of topicals for actinic keratosis field therapy
This study aims to systematically review randomized controlled trials on topical treatments for actinic keratosis field cancerization, following the PRISMA guidelines. Clinical recommendations were based on the Oxford Centre for Evidence-Based Medicine. We identified 20 original randomized controlled trials for topical cutaneous field therapy. 0.5% 5-Fluorouracil/salicylic acid and 0.5% 5-fluorouracil received a clinical recommendation grade of A, while diclofenac sodium received a clinical recommendation grade of B. Calcipotriol/5-fluorouracil, Imiquimod, sunscreen combination therapies, and tirbanibulin received a recomm...
Source: Archives of Dermatological Research - March 18, 2024 Category: Dermatology Source Type: research
A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents
CONCLUSION: The virtual screen compounds have shown similar docking interaction with amino acid residues as shown by standard diclofenac sodium drugs. Therefore, the findings in the present study can be explored in the development of potent anti-inflammatory agents.PMID:38485685 | DOI:10.2174/0115701638281229240226101906 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Trupti Chitre Aniket Bhatambrekar Purvaj Hirode Shubhangi Thorat Sayli G Hajare Dinesh Garud Sakshi Jagdale Kalyani Asgaonkar Source Type: research
A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents
CONCLUSION: The virtual screen compounds have shown similar docking interaction with amino acid residues as shown by standard diclofenac sodium drugs. Therefore, the findings in the present study can be explored in the development of potent anti-inflammatory agents.PMID:38485685 | DOI:10.2174/0115701638281229240226101906 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Trupti Chitre Aniket Bhatambrekar Purvaj Hirode Shubhangi Thorat Sayli G Hajare Dinesh Garud Sakshi Jagdale Kalyani Asgaonkar Source Type: research
A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents
CONCLUSION: The virtual screen compounds have shown similar docking interaction with amino acid residues as shown by standard diclofenac sodium drugs. Therefore, the findings in the present study can be explored in the development of potent anti-inflammatory agents.PMID:38485685 | DOI:10.2174/0115701638281229240226101906 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Trupti Chitre Aniket Bhatambrekar Purvaj Hirode Shubhangi Thorat Sayli G Hajare Dinesh Garud Sakshi Jagdale Kalyani Asgaonkar Source Type: research
A Combination of Pharmacophore Generation, Ligand-based Virtual Screening, Atom-based 3D-QSAR, and Molecular Docking Studies on Febuxostat-based Amides Analogues as Anti-inflammatory Agents
CONCLUSION: The virtual screen compounds have shown similar docking interaction with amino acid residues as shown by standard diclofenac sodium drugs. Therefore, the findings in the present study can be explored in the development of potent anti-inflammatory agents.PMID:38485685 | DOI:10.2174/0115701638281229240226101906 (Source: Current Drug Discovery Technologies)
Source: Current Drug Discovery Technologies - March 14, 2024 Category: Drugs & Pharmacology Authors: Trupti Chitre Aniket Bhatambrekar Purvaj Hirode Shubhangi Thorat Sayli G Hajare Dinesh Garud Sakshi Jagdale Kalyani Asgaonkar Source Type: research
Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1 α/NF-κB and SIRT1/p53 regulatory axes
In conclusion, for the first time, DCN counteracts acute kidney injury induced by DCF in rats by its anti-oxidative, anti-inflammatory, antinecrotic, and anti-apoptotic effects in a dose-dependent manner, which are mainly via targeting SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes.PMID:38471363 | DOI:10.1016/j.intimp.2024.111776 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 12, 2024 Category: Allergy & Immunology Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1 α/NF-κB and SIRT1/p53 regulatory axes
In conclusion, for the first time, DCN counteracts acute kidney injury induced by DCF in rats by its anti-oxidative, anti-inflammatory, antinecrotic, and anti-apoptotic effects in a dose-dependent manner, which are mainly via targeting SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes.PMID:38471363 | DOI:10.1016/j.intimp.2024.111776 (Source: International Immunopharmacology)
Source: International Immunopharmacology - March 12, 2024 Category: Allergy & Immunology Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Cancers, Vol. 16, Pages 1133: Topical Immunotherapy for Actinic Keratosis and Field Cancerization
nda Gilaberte
This comprehensive review delves into various immunotherapeutic approaches for the management of actinic keratoses (AKs), precancerous skin lesions associated with UV exposure. Although there are treatments whose main mechanism of action is immune modulation, such as imiquimod or diclofenac, other treatments, apart from their main effect on dysplastic cells, exert some immunological action, which in the end contributes to their efficacy. While treatments like 5-fluorouracil, imiquimod, photodynamic therapy, and nicotinamide are promising in the management of AKs, especially in immunocompetent individuals,...
Source: Cancers - March 12, 2024 Category: Cancer & Oncology Authors: Laura Bernal Masferrer Tamara Gracia Caza ña Isabel Bernad Alonso Marcial Álvarez-Salafranca Manuel Almenara Blasco Mar ía Gallego Rentero Ángeles Juarranz de la Fuente Yolanda Gilaberte Tags: Review Source Type: research
Synthesis of sustainable mesoporous sulfur-doped biobased carbon with superior performance sodium diclofenac removal: Kinetic, equilibrium, thermodynamic and mechanism
Environ Res. 2024 Mar 8:118595. doi: 10.1016/j.envres.2024.118595. Online ahead of print.ABSTRACTOver the last years, the strategy of employing inevitable organic waste and residue streams to produce valuable and greener materials for a wide range of applications has been proven an efficient and suitable approach. In this research, sulphur-doped porous biochar was produced through a single-step pyrolysis of birch waste tree in the presence of zinc chloride as chemical activator. The sulfur doping process led to a remarkable impact on the biochar structure. Moreover, it was shown that sulfur doping also had an important imp...
Source: Environmental Research - March 10, 2024 Category: Environmental Health Authors: Glaydson S Dos Reis Alejandro Grimm Denise Alves Fungaro Tao Hu Irineu A S de Brum Eder C Lima Mu Naushad Guilherme L Dotto Ulla Lassi Source Type: research
