Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128304230240327044201. Online ahead of print.ABSTRACTInflammation is critical to the formation and development of tumors and is closely associated with cancer. Therefore, addressing inflammation and the mediators that contribute to the inflammatory process may be a useful strategy for both cancer prevention and treatment. Tumor predisposition can be attributed to inflammation. It has been demonstrated that NSAIDs can modify the tumor microenvironment by enhancing apoptosis and chemosensitivity and reducing cell migration. There has been a recent rise in interest in drug repos...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Asmaa E Kassab Ehab M Gedawy Source Type: research
Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128304230240327044201. Online ahead of print.ABSTRACTInflammation is critical to the formation and development of tumors and is closely associated with cancer. Therefore, addressing inflammation and the mediators that contribute to the inflammatory process may be a useful strategy for both cancer prevention and treatment. Tumor predisposition can be attributed to inflammation. It has been demonstrated that NSAIDs can modify the tumor microenvironment by enhancing apoptosis and chemosensitivity and reducing cell migration. There has been a recent rise in interest in drug repos...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Asmaa E Kassab Ehab M Gedawy Source Type: research
Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF- κB/NLRP3/GSDMD signaling pathways
Food Chem Toxicol. 2024 Apr 4:114637. doi: 10.1016/j.fct.2024.114637. Online ahead of print.ABSTRACTDiclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug therapy to protect against such AKI is still needed. Diacetylrhein (DAR), an anthraquinone derivative, has different antioxidant and anti-inflammatory properties. Therefore, the aim of the current study was to investigate the renoprotective effect of DAR on DF-induced AKI while elucidating the potential underlying mechanism. Our results showed th...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Renoprotective effect of diacetylrhein on diclofenac-induced acute kidney injury in rats via modulating Nrf2/NF- κB/NLRP3/GSDMD signaling pathways
Food Chem Toxicol. 2024 Apr 4:114637. doi: 10.1016/j.fct.2024.114637. Online ahead of print.ABSTRACTDiclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug therapy to protect against such AKI is still needed. Diacetylrhein (DAR), an anthraquinone derivative, has different antioxidant and anti-inflammatory properties. Therefore, the aim of the current study was to investigate the renoprotective effect of DAR on DF-induced AKI while elucidating the potential underlying mechanism. Our results showed th...
Source: Food and Chemical Toxicology - April 6, 2024 Category: Food Science Authors: Abduallah Nasser Mansoure Mahmoud Elshal Manar G Helal Source Type: research
Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
CONCLUSION: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.PMID:38579298 | DOI:10.57187/s.3535 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Stephan Gut Marlene Rauch Manuel Haschke Carola A Huber Jan Gaertner Nadine Schur Christoph R Meier Julia Spoendlin Source Type: research
Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
CONCLUSION: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.PMID:38579298 | DOI:10.57187/s.3535 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Stephan Gut Marlene Rauch Manuel Haschke Carola A Huber Jan Gaertner Nadine Schur Christoph R Meier Julia Spoendlin Source Type: research
Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
CONCLUSION: In Switzerland, metamizole was increasingly claimed between 2014 and 2019. Metamizole was most frequently claimed by older adults and patients with comedications suggestive of underlying conditions, which can be worsened or caused by use of nonsteroidal anti-inflammatory drugs. The lack of studies regarding the effectiveness and safety of metamizole in this population warrants further investigation.PMID:38579298 | DOI:10.57187/s.3535 (Source: Swiss Medical Weekly)
Source: Swiss Medical Weekly - April 5, 2024 Category: General Medicine Authors: Stephan Gut Marlene Rauch Manuel Haschke Carola A Huber Jan Gaertner Nadine Schur Christoph R Meier Julia Spoendlin Source Type: research
H* < sub > ads < /sub > dynamics engineering via bimetallic Pd-Cu@MXene catalyst for enhanced electrocatalytic hydrodechlorination
In this study, bimetallic Pd-Cu@MXene catalysts were synthesized to achieve highly efficient removal of HECs. The alloy electrode (Pd-Cu@MX/CC) exhibited better EHDC performance in comparison to Pd@MX/CC electrode, resulting in diclofenac degradation efficiency of 93.3 ± 0.1%. The characterization analysis revealed that the Pd0/PdII ratio decreased by forming bimetallic Pd-Cu alloy. Density functional theory calculations further demonstrated the electronic configuration modulation of the Pd-Cu@MXene catalysts, optimizing binging energies for H* and thereby facilitating H*ads production and tuning the reduction capability ...
Source: Environmental Research - April 4, 2024 Category: Environmental Health Authors: Lan-Ying Liu Min-Hua Cui John Justo Ambuchi Shi-Ming Niu Xin-Hui Li Wo-Long Wang He Liu Guo-Shuai Liu Ai-Jie Wang Source Type: research
H* < sub > ads < /sub > dynamics engineering via bimetallic Pd-Cu@MXene catalyst for enhanced electrocatalytic hydrodechlorination
In this study, bimetallic Pd-Cu@MXene catalysts were synthesized to achieve highly efficient removal of HECs. The alloy electrode (Pd-Cu@MX/CC) exhibited better EHDC performance in comparison to Pd@MX/CC electrode, resulting in diclofenac degradation efficiency of 93.3 ± 0.1%. The characterization analysis revealed that the Pd0/PdII ratio decreased by forming bimetallic Pd-Cu alloy. Density functional theory calculations further demonstrated the electronic configuration modulation of the Pd-Cu@MXene catalysts, optimizing binging energies for H* and thereby facilitating H*ads production and tuning the reduction capability ...
Source: Environmental Research - April 4, 2024 Category: Environmental Health Authors: Lan-Ying Liu Min-Hua Cui John Justo Ambuchi Shi-Ming Niu Xin-Hui Li Wo-Long Wang He Liu Guo-Shuai Liu Ai-Jie Wang Source Type: research
Gut-gonad crosstalk in mice exposed to a "chemical cocktail" combining metabolomics and amplicon sequencing
Food Chem Toxicol. 2024 Mar 30:114627. doi: 10.1016/j.fct.2024.114627. Online ahead of print.ABSTRACTTestes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of "chemical cocktails" (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented with selenium, a well-known antagonist against many pollutants. Our results revealed that the steroid 5-alpha-androstan-17-bet...
Source: Food and Chemical Toxicology - April 1, 2024 Category: Food Science Authors: C Parra-Mart ínez M Selma-Royo B Callej ón-Leblic M C Collado N Abril T Garc ía-Barrera Source Type: research
Gut-gonad crosstalk in mice exposed to a "chemical cocktail" combining metabolomics and amplicon sequencing
Food Chem Toxicol. 2024 Mar 30:114627. doi: 10.1016/j.fct.2024.114627. Online ahead of print.ABSTRACTTestes are very prone to be damaged by environmental pollutants, but there is a lack of information about the impact of "chemical cocktails" (CC) on the testicular metabolome and the possible influence in the gut-gonad crosstalk. For this, BALB/c mice were given flumequine and diclofenac orally in food and potentially toxic trace elements (Cd, Hg, As) in drinking water. A mice group was supplemented with selenium, a well-known antagonist against many pollutants. Our results revealed that the steroid 5-alpha-androstan-17-bet...
Source: Food and Chemical Toxicology - April 1, 2024 Category: Food Science Authors: C Parra-Mart ínez M Selma-Royo B Callej ón-Leblic M C Collado N Abril T Garc ía-Barrera Source Type: research
Fasting potentiates diclofenac-induced liver injury via inductions of oxidative/endoplasmic reticulum stresses and apoptosis, and inhibition of autophagy by depleting hepatic glutathione in mice
Food Chem Toxicol. 2024 Mar 29:114624. doi: 10.1016/j.fct.2024.114624. Online ahead of print.ABSTRACTDiclofenac, a widely used non-steroidal anti-inflammatory drug, can cause liver damage via its metabolic activation by hepatic CYP450s and UGT2B7. Fasting can affect drug-induced liver injury by modulating the hepatic metabolism, but its influence on diclofenac hepatotoxicity is unknown. Thus, we investigated diclofenac-induced liver damage after fasting in mice, and the cellular events were examined. Male ICR mice fasted for 16 h showed the elevation of CYP3A11, but the decreases of UGT2B7, glutathione (GSH), and GSH S-tra...
Source: Food and Chemical Toxicology - March 31, 2024 Category: Food Science Authors: Doyoung Kwon Hyeji Seo Sou Hyun Kim Ki Wung Chung Jaewon Lee Young-Suk Jung Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
Application of non-lethal bioSPME-LC-MS/MS for the detection of human pharmaceuticals in soft corals: A survey at the North Nilandhe atoll (Maldives)
Chemosphere. 2024 Mar 28:141781. doi: 10.1016/j.chemosphere.2024.141781. Online ahead of print.ABSTRACTAt present the information regarding the occurrence of human pharmaceuticals (PhaCs) in coral reefs and their potential impacts on the associated fauna is limited. To optimize the collection of data in these delicate environments, we employed a solid-phase microextraction (bioSPME) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) procedure that enabled in vivo determinations in soft corals. Specifically, we researched the antibiotics Ofloxacin Sulfamethoxazole and Clarithromycin, the anti-inflammat...
Source: Chemosphere - March 30, 2024 Category: Chemistry Authors: Alessandro Becchi Marco Mantovani Marina Lasagni Elena Collina Simone Montano Paolo Galli Francesco Saliu Source Type: research
