A randomized controlled trial of rectal versus intramuscular diclofenac for post-operative analgesia after open myomectomy
To determine the efficacy and safety of rectal versus intramuscularly administered Diclofenac in reducing post-operative pain in the first 24 h after open-myomectomy. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - November 29, 2023 Category: OBGYN Authors: John C. Irechukwu, George U. Eleje, Bobbie C. Iwe, Okechukwu C. Ikpeze, Arinze C. Ikeotuonye, Eziaha E. Ede, Chidinma C. Okafor, Divinefavour E. Malachy, Chigozie G. Okafor Tags: Full length article Source Type: research
A premature stop codon in the CYP2C19 gene may explain the unexpected sensitivity of vultures to diclofenac toxicity
Toxicol Appl Pharmacol. 2023 Nov 25:116771. doi: 10.1016/j.taap.2023.116771. Online ahead of print.ABSTRACTThe unintended environmental exposure of vultures to diclofenac has resulted in the deaths of millions of old-world vultures on the Asian subcontinent. While toxicity has been since associated with a long half-life of elimination and zero order metabolism, the actual constraint in biotransformation is yet to be clarified. For this study we evaluated if the evident zero order metabolism could be due to defects in the CYP2C9/2C19 enzyme system. For this, using whole genome sequencing and de-novo transcriptome alignment,...
Source: Toxicology and Applied Pharmacology - November 28, 2023 Category: Toxicology Authors: Emmanuel Oluwasegun Adawaren Christiaan Labuschagne Aron Abera Vinny Naidoo Source Type: research
A premature stop codon in the CYP2C19 gene may explain the unexpected sensitivity of vultures to diclofenac toxicity
Toxicol Appl Pharmacol. 2023 Nov 25:116771. doi: 10.1016/j.taap.2023.116771. Online ahead of print.ABSTRACTThe unintended environmental exposure of vultures to diclofenac has resulted in the deaths of millions of old-world vultures on the Asian subcontinent. While toxicity has been since associated with a long half-life of elimination and zero order metabolism, the actual constraint in biotransformation is yet to be clarified. For this study we evaluated if the evident zero order metabolism could be due to defects in the CYP2C9/2C19 enzyme system. For this, using whole genome sequencing and de-novo transcriptome alignment,...
Source: Toxicology and Applied Pharmacology - November 28, 2023 Category: Toxicology Authors: Emmanuel Oluwasegun Adawaren Christiaan Labuschagne Aron Abera Vinny Naidoo Source Type: research
Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function
Biomed Pharmacother. 2023 Nov 23;169:115932. doi: 10.1016/j.biopha.2023.115932. Online ahead of print.ABSTRACTUrolithin A (UA) is an ellagitannin-derived postbiotic metabolite which emerged as a promising health-boosting agent, promoting mitophagy, improving skeletal muscle function, and suppressing the inflammatory response. However, phase II intestinal metabolism severely limits its biopotency, leading to the formation of nonactive glucuronides. To address this constraint, a set of new UA derivatives (UADs), conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs), was synthesized. The bioavailability and inhibitory...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 24, 2023 Category: Drugs & Pharmacology Authors: Maciej Korczak Piotr Roszkowski Weronika Skowro ńska Klaudia M Żołdak Dominik Popowski Sebastian Granica Jakub P Piwowarski Source Type: research
Urolithin A conjugation with NSAIDs inhibits its glucuronidation and maintains improvement of Caco-2 monolayers' barrier function
Biomed Pharmacother. 2023 Nov 23;169:115932. doi: 10.1016/j.biopha.2023.115932. Online ahead of print.ABSTRACTUrolithin A (UA) is an ellagitannin-derived postbiotic metabolite which emerged as a promising health-boosting agent, promoting mitophagy, improving skeletal muscle function, and suppressing the inflammatory response. However, phase II intestinal metabolism severely limits its biopotency, leading to the formation of nonactive glucuronides. To address this constraint, a set of new UA derivatives (UADs), conjugated with nonsteroidal anti-inflammatory drugs (NSAIDs), was synthesized. The bioavailability and inhibitory...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 24, 2023 Category: Drugs & Pharmacology Authors: Maciej Korczak Piotr Roszkowski Weronika Skowro ńska Klaudia M Żołdak Dominik Popowski Sebastian Granica Jakub P Piwowarski Source Type: research
