Lubricating Microneedles System with Multistage Sustained Drug Delivery for the Treatment of Osteoarthritis
In this study, a lubricating microneedles (MNs) system for the treatment of osteoarthritis with multistage sustained drug delivery and great reduction in skin damage during MNs penetration is developed. The bilayer dissolvable MNs system, namely HA-DCF@PDMPC, is prepared by designating the composite material of hyaluronic acid (HA) and covalently conjugated drug compound (HA-DCF) as the MNs tips and then modifying the surface of MNs tips with a self-adhesive lubricating copolymer (PDMPC). The MNs system is designed to achieve sustained drug release of DCF via ester bond hydrolysis, physical diffusion from MNs tips, and bre...
Source: Small - January 16, 2024 Category: Nanotechnology Authors: Kexin Chen,
Yanlong Zhao,
Weiwei Zhao,
Xiaowei Mao,
Dan Li,
Yuguang Wang,
Shaomei Shang,
Hongyu Zhang Tags: Research Article Source Type: research
The radiation- and chemo-sensitizing capacity of diclofenac can be predicted by a decreased lactate metabolism and stress response
An enhanced aerobic glycolysis ( “Warburg effect”) associated with an increase in lactic acid in the tumor microenvironment contributes to tumor aggressiveness and resistance to radiation and chemotherapy. We i... (Source: Radiation Oncology)
Source: Radiation Oncology - January 16, 2024 Category: Cancer & Oncology Authors: Melissa Schwab, Ali Bashiri Dezfouli, Mohammad Khosravi, Bayan Alkotub, Lisa Bauer, Mohammad Javed Tahmasebi Birgani and Gabriele Multhoff Tags: Case Report Source Type: research
Molecules, Vol. 29, Pages 380: Dendrimer Coated Silica as a Sorbent for Dispersive Solid-Phase Extraction of Select Non-Steroidal Anti-Inflammatory Drugs from Water
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Non-steroidal anti-inflammatory drugs (NSAIDs) have been recognized as a potentially serious threat to the natural environment. NSAIDs are popular painkillers, and the main pathway for them to reach natural water is via discharge from wastewater and sewage treatment plants. In order to monitor contamination caused by these drugs, as well as their impact on the environment, a new material based on Silica Gel 60, functionalized with a dendrimeric copolymer of methylamine and 1,4-butanediol diglycidyl ether (named MA-BDDE), was prepared. Initial physicochemical characterization of the MA-BDDE material was carried out u...
Source: Molecules - January 12, 2024 Category: Chemistry Authors: Piotr Ścigalski Przemys ław Kosobucki Tags: Article Source Type: research
Biodegradation behaviour of pharmaceutical compounds and selected metabolites in activated sludge. A forecasting decision system approach
AbstractSociety's support upon chemicals over the last few decades has led to their increased production, application and discharge into the environment. Wastewater treatment plants (WWTPs) contain a multitude of these chemicals such us; pharmaceutical compounds (PCs). Often, their biodegradability by activated sludge microorganisms is significant for their elimination during wastewater treatment. In this paper the focus is laid on two PCs carbamazepine (CBZ) and diclofenac (DCF) and their main transformation products (TPs). Laboratory degradation tests with these two pharmaceuticals using activated sludge as inoculum unde...
Source: Journal of Environmental Health Science and Engineering - January 8, 2024 Category: Environmental Health Source Type: research
Triple-layered platform utilizing electrospun nanofibers and 3D-printed sodium alginate-based hydrogel for effective topical treatment of rheumatoid arthritis
Int J Biol Macromol. 2024 Jan 4:129195. doi: 10.1016/j.ijbiomac.2023.129195. Online ahead of print.ABSTRACTRheumatoid arthritis (RA), an autoimmune disease impacting the joints, significantly diminishes the quality of life for patients. Conventional treatments predominantly rely on oral or injectable formulations, underscoring the crucial need for an effective topical remedy. The present study reports a novel triple-layered transdermal platform for efficient RA treatment. The patches are based on an electrospun/electrosprayed diclofenac (DIC)-conjugated polyvinyl alcohol (PVA) nanofibers/nanoparticles (NFs/NPs) composite l...
Source: International Journal of Biological Macromolecules - January 6, 2024 Category: Biochemistry Authors: Hend A Elshabrawy Ahmed S Abo Dena Ibrahim M El-Sherbiny Source Type: research
Model-Based Meta-Analysis Supporting the Combination of Acetaminophen and Topical Diclofenac in Acute Pain: A Therapy for Mild-to-Moderate Osteoarthritis Pain?
ConclusionOur results indicate greater pain reduction and opioid-sparing efficacy for the AtopD combination versus acetaminophen monotherapy. Given the similar pain pathways and mechanisms of action of the two drugs in acute and mild-to-moderate OA pain, comparable beneficial effects from the combination therapy may be anticipated following extrapolation to chronic OA pain. Prospective RCTs and real-world studies in OA pain are needed to confirm the differences in the efficacy of the combination treatment observed in our study. (Source: Pain and Therapy)
Source: Pain and Therapy - January 6, 2024 Category: Anesthesiology Source Type: research
Model-Based Assessment of the Liver Safety Profile of Acetaminophen to Support its Combination Use with Topical Diclofenac in Mild-to-Moderate Osteoarthritis Pain
ConclusionsOverall, our analysis shows that short-term (~ 8–16 weeks) acetaminophen use at therapeutically recommended doses is associated with a low risk of clinically relevant changes in liver enzymes. Given the good tolerability of topical diclofenac, the findings support the safety of the combination of acetaminophen and topical diclofenac, at le ast over the short term, as treatment for mild-to-moderate OA pain. (Source: Pain and Therapy)
Source: Pain and Therapy - January 6, 2024 Category: Anesthesiology Source Type: research
PPAR γ, NF-κB and the UPR pathway as new molecular targets in the anti-inflammatory actions of NSAIDs: Novel applications in cancers and central nervous system diseases?
Adv Clin Exp Med. 2024 Jan 5. doi: 10.17219/acem/174243. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, diclofenac, ibuprofen, or celecoxib have a well-established and unquestionable role in the human therapeutic arsenal, but still new perspectives are being discovered. This review presents new anti-inflammatory mechanisms of NSAIDs action, other than the classical one, i.e., the inhibition of cyclooxygenase (COX) isoforms leading to the prostanoids synthesis blockage. Literature data show that this group of drugs can activate anti-inflammatory peroxisome proliferator-activate...
Source: Adv Data - January 5, 2024 Category: Epidemiology Authors: Paulina Soko łowska Layla Bleibel Jacek Owczarek Anna Wiktorowska-Owczarek Source Type: research
PPAR γ, NF-κB and the UPR pathway as new molecular targets in the anti-inflammatory actions of NSAIDs: Novel applications in cancers and central nervous system diseases?
Adv Clin Exp Med. 2024 Jan 5. doi: 10.17219/acem/174243. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, diclofenac, ibuprofen, or celecoxib have a well-established and unquestionable role in the human therapeutic arsenal, but still new perspectives are being discovered. This review presents new anti-inflammatory mechanisms of NSAIDs action, other than the classical one, i.e., the inhibition of cyclooxygenase (COX) isoforms leading to the prostanoids synthesis blockage. Literature data show that this group of drugs can activate anti-inflammatory peroxisome proliferator-activate...
Source: Adv Data - January 5, 2024 Category: Epidemiology Authors: Paulina Soko łowska Layla Bleibel Jacek Owczarek Anna Wiktorowska-Owczarek Source Type: research
PPAR γ, NF-κB and the UPR pathway as new molecular targets in the anti-inflammatory actions of NSAIDs: Novel applications in cancers and central nervous system diseases?
Adv Clin Exp Med. 2024 Jan 5. doi: 10.17219/acem/174243. Online ahead of print.ABSTRACTNon-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, diclofenac, ibuprofen, or celecoxib have a well-established and unquestionable role in the human therapeutic arsenal, but still new perspectives are being discovered. This review presents new anti-inflammatory mechanisms of NSAIDs action, other than the classical one, i.e., the inhibition of cyclooxygenase (COX) isoforms leading to the prostanoids synthesis blockage. Literature data show that this group of drugs can activate anti-inflammatory peroxisome proliferator-activate...
Source: Adv Data - January 5, 2024 Category: Epidemiology Authors: Paulina Soko łowska Layla Bleibel Jacek Owczarek Anna Wiktorowska-Owczarek Source Type: research
A sustainable nano-hybrid system of laccase@M-MWCNTs for multifunctional PAHs and PhACs removal from water, wastewater, and lake water
This study examined the use of modified multiwall carbon nanotubes (M-MWCNTs) with immobilized laccase (L@M-MWCNTs) for removing ciprofloxacin (Cip), carbamazepine (Cbz), diclofenac (Dcf), benzo[a]pyrene (Bap), and anthracene (Ant) from different water samples. The synthesized materials were characterized using an array of advanced analytical techniques. The physical immobilization of laccase onto M-MWCNTs was confirmed through Scanning electron microscope (SEM)-dispersive X-ray spectroscopy (EDS) analysis and Brunner-Emmet-Teller (BET) surface area measurements. The specific surface area of M-MWCNTs decreased by 65% upon ...
Source: Environmental Research - January 4, 2024 Category: Environmental Health Authors: Ruqayah Ali Grmasha Osamah J Al-Sareji M ónika Meiczinger Csilla Stenger-Kov ács Raed A Al-Juboori Mikl ós Jakab Edina Lengyel Viola Somogyi Mohammad Amir Khan Khalid S Hashim Source Type: research
A sustainable nano-hybrid system of laccase@M-MWCNTs for multifunctional PAHs and PhACs removal from water, wastewater, and lake water
This study examined the use of modified multiwall carbon nanotubes (M-MWCNTs) with immobilized laccase (L@M-MWCNTs) for removing ciprofloxacin (Cip), carbamazepine (Cbz), diclofenac (Dcf), benzo[a]pyrene (Bap), and anthracene (Ant) from different water samples. The synthesized materials were characterized using an array of advanced analytical techniques. The physical immobilization of laccase onto M-MWCNTs was confirmed through Scanning electron microscope (SEM)-dispersive X-ray spectroscopy (EDS) analysis and Brunner-Emmet-Teller (BET) surface area measurements. The specific surface area of M-MWCNTs decreased by 65% upon ...
Source: Environmental Research - January 4, 2024 Category: Environmental Health Authors: Ruqayah Ali Grmasha Osamah J Al-Sareji M ónika Meiczinger Csilla Stenger-Kov ács Raed A Al-Juboori Mikl ós Jakab Edina Lengyel Viola Somogyi Mohammad Amir Khan Khalid S Hashim Source Type: research
Betulin Accelerated the Functional Recovery of Injured Muscle in a Mouse Model of Muscle Contusion
This study aimed to explore the therapeutic effects of betulin on muscle contusion that produced by the drop-mass method in mice. C57BL/6 mice were randomly assigned to control (no injury), only drop-mass injury (Injury), diclofenac treatment (Injury+diclofenac), and betulin treatment (Injury+betulin) groups. Injury was executed on the gastrocnemius of the right hind limb, and then phosphate-buffered saline (PBS), diclofenac, or betulin were oral gavage administrated respectively for 7 days. Results revealed that betulin significantly restored motor functions based on locomotor activity assessments, rota-rod test, and foot...
Source: International Journal of Medical Sciences - January 2, 2024 Category: Biomedical Science Authors: Yueh-Hsiu Lu Yi-Fu Huang Cheng-Pu Hsieh Jr-Kai Chen Hsuan-Ying Chen Show-Mei Chuang Source Type: research
GSE235393 Transcriptomic analysis of adult ovaries and testes exposed to the cocktails of pharmaceuticals ibuprofen (IBU), 2hydroxyIBU (2hIBU), diclofenac (DCF) and 17a ethinyl-estradiol (EE2) in mice
In this study, we investigated the impact of chronic exposure to a mixture containing ibuprofen, 2hydroxy-ibuprofen, diclofenac, and EE2 at two environmentally relevant doses (added to the drinking water from fetal life, 8.5 dpc, until sexual maturity) on the reproductive tract in F1 exposed mice and their F2 offspring. In adult F1 and F2 animals, chronic exposure to low environmental doses of IBU, 2hydroxy-IBU, DCF, and EE2 mixtures, affected reproductive organ maturation, estrous cyclicity (in females), spermiogenesis (in males), and some sperm parameters in F2 males. Transcriptomics further revealed significant changes ...
Source: GEO: Gene Expression Omnibus - January 1, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
