A Single Dose of Intrathecal Morphine Without Local Anesthetic Provides Long-Lasting Postoperative Analgesia After Radical Prostatectomy and Nephrectomy
CONCLUSIONS: The results of our study confirmed that preoperative intrathecal morphine provides long-lasting analgesia and reduces the need for postoperative systemic administration of opioids. Adverse effects are minor and comparable between groups.PMID:38300193 | DOI:10.1016/j.jopan.2023.10.019 (Source: Journal of Perianesthesia Nursing)
Source: Journal of Perianesthesia Nursing - February 1, 2024 Category: Nursing Authors: Alice Kurzova Jiri Malek Petr Klezl Ladislav Hess Jiri Sliva Source Type: research
Toxic effects of combined exposure to cadmium and diclofenac on freshwater crayfish (Procambarus clarkii): Insights from antioxidant enzyme activity, histopathology, and gut microbiome
This study examined the effects of combined exposure to Cd and DCF on the tissue accumulation, physiology, biochemistry, and gut microflora of P. clarkii. The results showed that Cd and DCF accumulated in tissues in the order of hepatopancreas > gill > intestine > muscle. The hepatopancreas and intestines were subjected to severe oxidative stress, with significantly increased antioxidant enzyme activity. Pathological examination revealed lumen expansion and epithelial vacuolisation in the hepatopancreas and damage to the villous capillaries and wall in the intestine. The co-exposure to Cadmium (Cd) and Diclofenac ...
Source: Aquatic Toxicology - January 31, 2024 Category: Toxicology Authors: Hucheng Jiang Runbo Li Muzi Zhao Xinran Peng Mengling Sun Chongwan Liu Guoxing Liu Hui Xue Source Type: research
Subchronic doses of artemether-lumefantrine, ciprofloxacin and diclofenac precipitated inflammatory and immunological dysfunctions in female Wistar rats
This study evaluated the effects of co-administration of artemether-lumefantrine (AL), ciprofloxacin (CPX) and diclofenac (DFC) on inflammatory and immunological status of female Wistar rats. Ninety-six female Wistar rats were assigned into eight groups of twelve animals each. Group A was control, groups B, C, D, E, F, G and H were administered AL, CPX, DFC, AL + CPX, AL + DFC, CPX + DFC and AL + CPX + DFC respectively. Dosages of administered drugs were 178 mg/kg b/w of AL, 185 mg/kg b/w of CPX and 9 mg/kg b/w of DFC. Animals were sacrificed after 6 and 12 weeks of oral administration. Blood was obtained through cardiac p...
Source: Cytokine - January 30, 2024 Category: Molecular Biology Authors: Juliana Oluwafunmilayo Ajayi Emmanuel Bukoye Oyewo Adeniran Sanmi Adekunle Peace Temidayo Ige Peter Ayomide Akomolafe Source Type: research
Breast milk concentrations of acetaminophen and diclofenac - unexpectedly high mammary transfer of the general-purpose drug acetaminophen
Breastfeeding is considered to be the most effective way of ensuring the health and survival of newborns. However, mammary transfer of drugs administered to mothers to breastfeeding infants remains a pressing ... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - January 29, 2024 Category: OBGYN Authors: Ryo Tamaki, Kiwamu Noshiro, Ayako Furugen, Ayako Nishimura, Hiroshi Asano, Hidemichi Watari, Masaki Kobayashi and Takeshi Umazume Tags: Research Source Type: research
Oxadiazole Derivatives of Diclofenac as an Anti-proliferative Agent for B-cell Non-Hodgkin Lymphoma: An In vitro and In Silico Studies
CONCLUSION: The compound (II) can be a potential therapeutic candidate for B-cell non-Hodgkin lymphoma and deserves further development as a novel anti-lymphoma agent.PMID:38279758 | DOI:10.2174/0115734064290905231228110023 (Source: Medicinal Chemistry)
Source: Medicinal Chemistry - January 27, 2024 Category: Chemistry Authors: Shaista Qayyum Almas Jabeen Sajda Ashraf Faiza Seraj Khalid Mohammad Khan Rafat Ali Siddiqui None Zaheer Ul-Haq Source Type: research
Preemptive use of anti-inflammatories and analgesics in oral surgery: a review of systematic reviews
Conclusion: Further randomized clinical trials should be conducted to confirm these findings, given the wide variety of drugs, doses, and routes of administration used. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 24, 2024 Category: Drugs & Pharmacology Source Type: research
Evaluation of polyherbal gel for musculoskeletal injuries in industrial workers
CONCLUSION: Industrial workers with musculoskeletal injuries benefited from the use of polyherbal gel for pain and inflammation relief. The polyherbal gel is natural, cost-effective, and easy to formulate.PMID:38251085 | DOI:10.3233/WOR-230178 (Source: Work)
Source: Work - January 22, 2024 Category: Occupational Health Authors: Qurat Ul Ain Imran Ahmad Khan Muhammad Asif Raza Ahsan Anjum Maliha Khalid Khan Perwasha Perwasha Shahid Ishaq Source Type: research
Protective Assessment of Novel (Bncs Formulation) against Brain Tumor
CONCLUSION: These findings indicated that, indeed, Diclofenac induces considerable ROSmediated apoptosis in SH-SY5Y cells, which further intriguingly ameliorated Diclofenacmediated cytotoxic effects on SH-SY5Y cells. This manuscript further collected information about available National and International patents published or granted in preparation of and thereof applications against motor and non-motor brain dysfunctions.PMID:38231063 | DOI:10.2174/0115748928272753231212043701 (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - January 17, 2024 Category: Cancer & Oncology Authors: Anuradha Mishra Afza Ahmad Irfan Ahmad Ansari Rohit Kumar Tiwari Source Type: research
