Chemotherapy induced peripheral neuropathy
88yo with h/o chemotherapy induced neuropathy in BLE. Tried gabapentin, duloxtine, lyrica, topamax, ALA, topical lido/voltaren/menthol/capsaicin, TENS. Pt not interested in SCS, worried about sedation. Lives alone and also given age, I've tried to hold off on TCAs...but I may need to go that route as pain is worsening. What else can I offer? LESI?? (Source: Student Doctor Network)
Source: Student Doctor Network - August 22, 2023 Category: Universities & Medical Training Authors: oneforfighting Tags: Pain Medicine Source Type: forums

Mark Cuban ’s Cost Plus Drugs
New consumer direct pharmacy started by Mark Cuban. They have a few meds that might help our patients. Looks very easy to create an account and order meds….. Lidocaine 5% ointment - $5 Lidocaine 5% patches - 30ct- $46 Celecoxib- $9 Diclofenac 3% gel - 100g tube - $50 Diclofenac sodium ER - $6 (Source: Student Doctor Network)
Source: Student Doctor Network - June 27, 2022 Category: Universities & Medical Training Authors: DesertDoc16 Tags: Pain Medicine Source Type: forums

Worst Article Ever
Medications for Pain: The Overlooked Drugs to Reconsider When Prescribing for Pain A review of pain medications of the past and how they may help to optimize the treatments of today. www.doximity.com Written by a pharmacist and horrible advice for 95% of it. Insanity. Would offer choline mg trilisate for young healthy folks if failed celebrex, mobic, diclofenac, and otc nsaids. I do use SMRs as opiate alternatives. The rest of the article is pure trash. (Source: Student Doctor Network)
Source: Student Doctor Network - September 19, 2021 Category: Universities & Medical Training Authors: lobelsteve Tags: Pain Medicine Source Type: forums

Curcumin as harm reduction NSAID misuse
Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study The purpose of this study was to compare the efficacy and safety of curcumin with those of diclofenac in the treatment of knee osteoarthritis (OA). In this randomized, open-label, parallel, active controlled clinical study, 139 patients with knee OA were randomly assigned to receive either a... trialsjournal.biomedcentral.com Curcumin has similar efficacy to diclofenac but demonstrated better tolerance among patients with knee OA. Cu...
Source: Student Doctor Network - August 25, 2019 Category: Universities & Medical Training Authors: drusso Tags: Pain Medicine Source Type: forums

Re: Diclofenac use and cardiovascular risks: series of nationwide cohort studies
(Source: BMJ Comments)
Source: BMJ Comments - October 9, 2018 Category: General Medicine Source Type: forums

NSAIDs inhibit ovulation
I think this is worth posting in the Pregnancy forum, as people with CF are often put on a regimen of Ibuprofen. It was not one of the three NSAIDs tested, but it's perhaps relevant nonetheless, especially at the CF dose. And even for CFers not trying to conceive, this may help understand your cycle and it's relationship to your meds (as well as things like weight, stress, and infection). http://www.medscape.com/viewarticle/846552 "The women were assigned to one of four treatment regimens: diclofenac 100 mg/day, naproxen 500 mg twice daily, etoricoxib 90 mg/day, or placebo.... 'All control patients on placebo ovul...
Source: Cystic Fibrosis Pregnancy Forum - November 17, 2015 Category: Respiratory Medicine Authors: Melissa75 Tags: Pregnancy Source Type: forums

Do you use diclofenac?
A study has suggested that there is an increased CV risk of up to 63% with diclofenac. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1001388Is this effect unique to diclofenac or does it just reflect NSAIDS as a class?sadian (Source: Doc2Doc BMJ Cardiology)
Source: Doc2Doc BMJ Cardiology - February 15, 2013 Category: Cardiology Authors: sadian Source Type: forums