Inhibitory effect of diacerein on diclofenac-induced acute nephrotoxicity in rats via modulating SIRT1/HIF-1 α/NF-κB and SIRT1/p53 regulatory axes

In conclusion, for the first time, DCN counteracts acute kidney injury induced by DCF in rats by its anti-oxidative, anti-inflammatory, antinecrotic, and anti-apoptotic effects in a dose-dependent manner, which are mainly via targeting SIRT1/HIF-1α/NF-κB and SIRT1/p53 regulatory axes.PMID:38471363 | DOI:10.1016/j.intimp.2024.111776
Source: International Immunopharmacology - Category: Allergy & Immunology Authors: Source Type: research