New insights into the roles of Irisin in diabetic cardiomyopathy and vascular diseases
Biomed Pharmacother. 2024 Apr 24;175:116631. doi: 10.1016/j.biopha.2024.116631. Online ahead of print.ABSTRACTDiabetes mellitus (DM) is a prevalent chronic disease in the 21st century due to increased lifespan and unhealthy lifestyle choices. Extensive research indicates that exercise can play a significant role in regulating systemic metabolism by improving energy metabolism and mitigating various metabolic disorders, including DM. Irisin, a well-known exerkine, was initially reported to enhance energy expenditure by indicating the browning of white adipose tissue (WAT) through peroxisome proliferator-activated receptor �...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - April 25, 2024 Category: Drugs & Pharmacology Authors: Tiandong Zhang Qian Yi Wenhua Huang Jianguo Feng Huan Liu Source Type: research
Metformin for Type 2 diabetes mellitus
Acad Emerg Med. 2024 Apr 25. doi: 10.1111/acem.14922. Online ahead of print.NO ABSTRACTPMID:38661224 | DOI:10.1111/acem.14922 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - April 25, 2024 Category: Emergency Medicine Authors: Blair J MacDonald Ricky D Turgeon James McCormack Source Type: research
Colorectal Cancer and Subsequent Diabetes Risk: A Population-based Cohort Study in Taiwan
CONCLUSION: Patients with CRC are associated with an elevated risk of diabetes mellitus, and long-term chemotherapy, particularly involving capecitabine, increases diabetes mellitus risk. Thus, monitoring blood glucose levels is crucial for patients with CRC, especially during extended chemotherapy.PMID:38661006 | DOI:10.1210/clinem/dgae257 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Hsin-Yin Hsu Yih-Jong Chern Min-Shu Hsu Tzu-Lin Yeh Ming-Chieh Tsai Jing-Rong Jhuang Cheng-Tzu Hsieh Chun-Ju Chiang Wen-Chung Lee Lee-Ching Hwang Kuo-Liong Chien Source Type: research
Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity
CONCLUSION: FAO patients is associated with decreased mid-to-long-term weight loss outcomes; the alleviation of T2DM, hyperlipidemia and NAFLD; and decreased incidence of acid reflux postoperatively.PMID:38659480 | PMC:PMC11036498 | DOI:10.3748/wjg.v30.i13.1887 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Source Type: research
Mutational spectrum of CFTR in cystic fibrosis patients with gastrointestinal and hepatobiliary manifestations
CONCLUSION: The study reports novel and reported variants in the CFTR gene in CF patients in Pakistani population having distinct phenotypes. It also emphasizes screening suspected Pakistani CF patients for the p. (Met1Thr) variant because of its increased observance and prevalence in the study. Moreover, the findings also signify searching for additional pathogenic variants in the genome of CF patients, which may modify the phenotypes. The findings contribute valuable information for the diagnosis, genetic counseling, and potential therapeutic strategies for CF patients in Pakistan.PMID:38662334 | DOI:10.1007/s11033-024-0...
Source: Molecular Biology Reports - April 25, 2024 Category: Molecular Biology Authors: Nadia Waheed Rehmana Waris Maryam Naseer Ayesha Razzaq Nighat Haider Abid Ali Shah Asmat Ullah Source Type: research
Immunomodulation of Ethyl pyruvate on gestational diabetes mellitus in Mice; The impact on Th17/Treg balance
In conclusion, EP could modulate GDM in mice and might be a potential therapeutic strategy candidate for the treatment of patients with GDM.PMID:38663253 | DOI:10.1016/j.repbio.2024.100861 (Source: Reproductive Biology)
Source: Reproductive Biology - April 25, 2024 Category: Reproduction Medicine Authors: Min Zhao Xiuping Bian Li Meng Source Type: research
The latest emerging drugs for the treatment of diabetic cardiomyopathy
Expert Opin Pharmacother. 2024 Apr 25. doi: 10.1080/14656566.2024.2347468. Online ahead of print.ABSTRACTINTRODUCTION: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes mellitus involving multiple pathophysiologic mechanisms. In addition to hypoglycemic agents commonly used in diabetes, metabolism-related drugs, natural plant extracts, melatonin, exosomes, and rennin-angiotensin-aldosterone system are cardioprotective in DCM. However, there is a lack of systematic summarization of drugs for DCM.AREAS COVERED: In this review, the authors systematically summarize the most recent drugs used for the treatment...
Source: Expert Opinion on Pharmacotherapy - April 25, 2024 Category: Drugs & Pharmacology Authors: Minghao Li Lin Liu Chunyu Zhang Li Deng Yi Zhong Bin Liao Xiuying Li Ying Wan Jian Feng Source Type: research
Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity
CONCLUSION: FAO patients is associated with decreased mid-to-long-term weight loss outcomes; the alleviation of T2DM, hyperlipidemia and NAFLD; and decreased incidence of acid reflux postoperatively.PMID:38659480 | PMC:PMC11036498 | DOI:10.3748/wjg.v30.i13.1887 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Source Type: research
A Bibliometric Analysis of Study of Associations of Certain Genotypes with the Cardiovascular Form of Diabetic Neuropathy
Biomed Res Int. 2024 Apr 15;2024:6761451. doi: 10.1155/2024/6761451. eCollection 2024.ABSTRACTThis bibliometric analysis explores the landscape of research on the associations between specific genotypes and the cardiovascular form of diabetic neuropathy. Diabetes mellitus (DM) is a major contributor to premature mortality, primarily due to increased susceptibility to cardiovascular diseases. The global prevalence of DM is rising, with projections indicating further increases. Diabetic neuropathy, a complication of DM, includes the cardiovascular subtype, posing challenges in diagnosis and management. Understanding the gene...
Source: Biomed Res - April 25, 2024 Category: Research Authors: Nazira B Bekenova Tamara A Vochshenkova Nurgul Ablakimova Aliya Zhylkybekova Nadiar M Mussin Rustam K Albayev Asset A Kaliyev Amin Tamadon Source Type: research
Novel subtype of obesity influencing the outcomes of sleeve gastrectomy: Familial aggregation of obesity
CONCLUSION: FAO patients is associated with decreased mid-to-long-term weight loss outcomes; the alleviation of T2DM, hyperlipidemia and NAFLD; and decreased incidence of acid reflux postoperatively.PMID:38659480 | PMC:PMC11036498 | DOI:10.3748/wjg.v30.i13.1887 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 25, 2024 Category: Gastroenterology Authors: Ze-Yu Wang Yun-Fei Qu Tian-Ming Yu Zeng-Lin Liu Yu-Gang Cheng Ming-Wei Zhong San-Yuan Hu Source Type: research
Matrix metallopeptidase 9 contributes to the beginning of plaque and is a potential biomarker for the early identification of atherosclerosis in asymptomatic patients with diabetes
CONCLUSION: MMP9 may contribute to the initiation of atherosclerosis and may be a potential biomarker for the early identification of atherosclerosis in patients with diabetes.CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov, identifier NCT04424706.PMID:38660518 | PMC:PMC11039961 | DOI:10.3389/fendo.2024.1369369 (Source: Atherosclerosis)
Source: Atherosclerosis - April 25, 2024 Category: Cardiology Authors: Bingli Liu Liping Su Sze Jie Loo Yu Gao Ester Khin Xiaocen Kong Rinkoo Dalan Xiaofei Su Kok-Onn Lee Jianhua Ma Lei Ye Source Type: research
Heart failure: the grim reaper of the cardio ‐renal‐metabolic triad
ConclusionsIn a cohort of CKD patients, having HF contributes substantially to increased mortality and the risk of MACE, and these patients are less likely to start KRT. These findings highlight the urgent need for targeted therapeutic strategies and management plans for CKD patients, particularly those with concurrent HF, to enhance patient prognosis. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 25, 2024 Category: Cardiology Authors: Joakim Österman,
Ehab Al‐Sodany,
Ida Haugen Löfman,
Peter Barany,
Marie Evans Tags: Original Article Source Type: research
The Association Between Unintended Pregnancy and Perinatal Outcomes in Low ‐Risk Pregnancies: A Retrospective Registry Study in the Netherlands
This study used data (N = 9803) from a Dutch nationally representative registry of people with low-risk pregnancies receiving primary midwife-led care in the Netherlands between 2012 and 2020. Using logistic (mediation) regression analyses adjusted for potential confounders we investigated associations between unintended pregnancy and neonatal outcomes (low Apgar score, small for gestational age, and prematurity), parental morbidity (hypertension and gestational diabetes mellitus), and obstetric interventions (induction of labor, pain medication, assisted vaginal birth, and cesarean birth) and whether delayed initiation of...
Source: Journal of Midwifery and Women's Health - April 25, 2024 Category: Midwifery Authors: Amke M.G. van Tintelen,
Danielle E.M.C. Jansen,
Sophie H. Bolt,
J. Catja Warmelink,
Corine J. Verhoeven,
Jens Henrichs Tags: RESEARCH ARTICLE Source Type: research
Prevalence of high-risk human papillomavirus infection among women with diabetes mellitus in Accra, Ghana
There is increasing evidence of a higher risk and poorer prognosis of cervical cancer among women with diabetes mellitus (DM) compared to the general population. These are mediated by higher susceptibility to ... (Source: BMC Women's Health)
Source: BMC Women's Health - April 25, 2024 Category: OBGYN Authors: Yacoba Atiase, Kofi Effah, Comfort Mawusi Wormenor, Ethel Tekpor, Esu Aku Catherine Morkli, Eunice Boafo, Ernest Yorke, Robert Aryee, Nana Owusu Mensah Essel, Stephen Danyo, Seyram Kemawor and Josephine Akpalu Tags: Research Source Type: research
Evaluation of preadipocyte factor-1 (Pref-1) level in cord blood of newborns born by mothers with gestational diabetes mellitus (GDM)
Gestational diabetes mellitus (GDM) is the most common metabolic complication, which leads to short and long-term consequences in both mother and fetus exposed to hyperglycemia. The aetiology of this condition... (Source: BMC Pregnancy and Childbirth)
Source: BMC Pregnancy and Childbirth - April 25, 2024 Category: OBGYN Authors: Monika Kolska, Justyna Agier and El żbieta Kozłowska Tags: Research Source Type: research
