Acute Dapagliflozin Administration Ameliorates Cardiac Surgery-Associated Acute Kidney Injury in a Rabbit Model
CONCLUSIONS: Acute intravenous administration of dapagliflozin protects against CPB-induced AKI. Dapagliflozin may have direct renoprotective effects in renal tubular cells.PMID:38658352 | DOI:10.1253/circj.CJ-23-0864 (Source: Circulation Journal)
Source: Circulation Journal - April 24, 2024 Category: Cardiology Authors: Kensaku Matsuda Hiroshi Mitsuo Takuya Nishijima Hikaru Uchiyama Tobuhiro Nita Shogo Matsunaga Noriko Fujimoto Tomoki Ushijima Yusuke Ando Meikun Kan-O Gen Shinohara Satoshi Kimura Hiromichi Sonoda Akira Shiose Source Type: research
Vitronectin promotes insulin resistance in trophoblast cells by activating JNK in gestational diabetes mellitus
Cell Biol Int. 2024 Apr 23. doi: 10.1002/cbin.12167. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is a common disorder in the clinic, which may lead to severe detrimental outcomes both for mothers and infants. However, the underlying mechanisms for GDM are still not clear. In the present study, we performed label-free proteomics using placentas from GDM patients and normal controls. Vitronectin caused our attention among differentially expressed proteins due to its potential role in the pathological progression of GDM. Vitronectin was increased in the placentas of GDM patients, which was confirmed by W...
Source: Cell Biology International - April 24, 2024 Category: Cytology Authors: Yuejun Ju Ting Shen Zhanhong Guo Yinghong Kong Yun Huang Ji Hu Source Type: research
Impact of Combined Aerobic Training and Magnesium Supplementation on Serum Biomarkers and microRNA-155 and microRNA-21 Expression in Adipose Tissue of Type 2 Diabetic Rats: An Eight-Week Interventional Study
CONCLUSION: The combination of AT and Mg supplementation provides a synergistic effect that improves serum biomarkers and downregulates pro-inflammatory microRNAs in the VAT of T2DM rats. Meanwhile, Mg supplementation alone does not have a significant effect on pro-inflammatory microRNAs in the VAT. These findings suggest that such combined interventions could be a promising strategy for managing T2DM, potentially ameliorating inflammatory states and improving metabolic health.PMID:38658451 | DOI:10.1007/s12011-024-04186-5 (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 24, 2024 Category: Biology Authors: Rasha Raed Hamid Rastegar Hoseini Hiwa Ahmed Rahim Source Type: research
Persistent chronic calcific pancreatitis with intraductal calculi associated with secondary diabetes mellitus type 3 and diabetic ketoacidosis - A case report
Endocr Regul. 2024 Apr 24;58(1):101-104. doi: 10.2478/enr-2024-0011. Print 2024 Jan 1.ABSTRACTDiabetes mellitus type 3 refers to diabetes secondary to an existing disease or condition of the exocrine pancreas and is an uncommon cause of diabetes occurring due to pancreatogenic pathology. It accounts for 15-20% of diabetic patients in Indian and Southeast Asian continents. This is case report of a rare case of type 3 diabetes mellitus (T3DM) presenting with diabetic ketoacidosis (DKA). The patient was admitted for DKA along with complaint of hyperglycemia, blood glucose of 405 mg/dl with HbA1c level of 13.7%. Computed tomog...
Source: Endocrine Regulations - April 24, 2024 Category: Endocrinology Authors: Gurusha Bahl Dinesh K Upadhyay Madhumati Varma Rajveer Singh Subhankar Das Sadique Hussain Source Type: research
Differences between men and women in the prevalence of frailty and associated factors among older adults: evidence from ELSI-Brazil
Cad Saude Publica. 2024 Apr 22;40(3):e00144923. doi: 10.1590/0102-311XPT144923. eCollection 2024.ABSTRACTBased on a national representative sample of the population aged 50 years or older, this study aimed to estimate the prevalence of frailty among men and women, identify associated sociodemographic and health factors, and estimate the population attributable fraction. Data from the second wave (2019-2021) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil) were used. Frailty was classified based on the number of positive items among unintentional weight loss, exhaustion, low level of physical activity, slow gait, ...
Source: Cadernos de Saude Publica - April 24, 2024 Category: International Medicine & Public Health Authors: Silvia Lanziotti Azevedo da Silva Geraldo Eduardo Guedes de Brito Nair Tavares Milhem Ygnatios Juliana Vaz de Melo Mambrini Maria Fernanda Lima-Costa Juliana Lustosa Torres Source Type: research
Cardiovascular diseases in Switzerland - Prevalence and care
Praxis (Bern 1994). 2024 Mar;113(3):57-66.ABSTRACTCardiovascular diseases (CVD) represent a significant health problem worldwide and in Switzerland. Despite preventive measures and advances in treatment, cardiovascular diseases still lead to a significant number of hospitalizations in Switzerland (133 000 in 2021) and are for responsible for almost 1/3 of all deaths (19 600 in 2021). Emergency care for acute cardiovascular events now has a very high standard in Switzerland compared to other countries. However, there is a large discrepancy between evidence and daily practice (evidence-performance gap) in cardiovascular risk...
Source: Praxis - April 24, 2024 Category: General Medicine Authors: Thomas Rosemann Agn ès Bachofner Oliver Strehle Source Type: research
Effects of Paradoxical Sleep Deprivation on Oxidative Parameters in the Serum and Brain of Mice Submitted to the Animal Model of Hyperglycemia
Behav Brain Res. 2024 Apr 22:115008. doi: 10.1016/j.bbr.2024.115008. Online ahead of print.ABSTRACTThe present study aimed to investigate the effects of paradoxical sleep deprivation (PSD) on behavioral and oxidative stress parameters in the brain and serum of mice submitted to the animal model of hyperglycemia induced by alloxan, mimicking the main symptom of diabetes mellitus (DM). Adults C57BL/6 male and female mice received an injection of alloxan, and ten days later, the animals were submitted to the PSD for 36hr. The animals' behavioral parameters were evaluated in the open-field test. Oxidative stress parameters [Di...
Source: Behavioural Brain Research - April 24, 2024 Category: Neurology Authors: Julia Panato-Da Rosa Isadora Gava Sandrini Taise Possamai-Della Jorge M Aguiar-Geraldo Maria Lu ísa Machado-Laureano Alexandra I Zugno Jo ão Quevedo Samira S Valvassori Source Type: research
Effects of Paradoxical Sleep Deprivation on Oxidative Parameters in the Serum and Brain of Mice Submitted to the Animal Model of Hyperglycemia
Behav Brain Res. 2024 Apr 22:115008. doi: 10.1016/j.bbr.2024.115008. Online ahead of print.ABSTRACTThe present study aimed to investigate the effects of paradoxical sleep deprivation (PSD) on behavioral and oxidative stress parameters in the brain and serum of mice submitted to the animal model of hyperglycemia induced by alloxan, mimicking the main symptom of diabetes mellitus (DM). Adults C57BL/6 male and female mice received an injection of alloxan, and ten days later, the animals were submitted to the PSD for 36hr. The animals' behavioral parameters were evaluated in the open-field test. Oxidative stress parameters [Di...
Source: Brain Research - April 24, 2024 Category: Neurology Authors: Julia Panato-Da Rosa Isadora Gava Sandrini Taise Possamai-Della Jorge M Aguiar-Geraldo Maria Lu ísa Machado-Laureano Alexandra I Zugno Jo ão Quevedo Samira S Valvassori Source Type: research
Efficacy of a Telemonitoring System as a Complementary Strategy in the Treatment of Patients With Heart Failure: Randomized Clinical Trial
Comput Inform Nurs. 2024 Apr 24. doi: 10.1097/CIN.0000000000001115. Online ahead of print.ABSTRACTEpisodes of decompensation are the main cause of hospital admissions in patients with heart failure. For this reason, the use of mobile apps emerges as an excellent strategy to improve coverage, real-time monitoring, and timeliness of care. ControlVit is an electronic application for early detection of complications studied within the context of a tertiary university hospital. Patients were randomized to the use of ControlVit versus placebo, during a 6-month follow-up. The primary outcome was the difference in numbers of readm...
Source: Computers, Informatics, Nursing : CIN - April 24, 2024 Category: Nursing Authors: Diana M Achury-Salda ña Rafael A Gonzalez Angel Garcia Alejandro Mari ño Wilson R Bohorquez Source Type: research
Wound care in older people: overcoming the challenges of assessment and management
This article explores how conducting holistic wound assessments, setting realistic treatment aims, and using wound management strategies tailored to each person's needs and wishes can have a positive effect on older people's quality of life.PMID:38655588 | DOI:10.7748/nop.2024.e1471 (Source: Nursing Older People)
Source: Nursing Older People - April 24, 2024 Category: Nursing Authors: Joanna Swan Jane Mogford Katie Leek Source Type: research
Perioperative management and outcomes for posterior spinal fusion in patients with Friedreich ataxia: A single-center, retrospective study
CONCLUSIONS: Patients with Friedreich ataxia are at high risk for perioperative complications when undergoing posterior spinal fusion and coordinated multidisciplinary care is required at each stage. Future research should focus on the utility of intraoperative echocardiography, optimal anesthetic agent selection, and targeted fluid management to reduce postoperative cardiac complications.PMID:38655751 | DOI:10.1111/pan.14896 (Source: Paediatric Anaesthesia)
Source: Paediatric Anaesthesia - April 24, 2024 Category: Anesthesiology Authors: Elizabeth M O'Brien Natalie Neiswinter Kimberly Y Lin David Lynch Keith Baldwin Victoria Profeta John M Flynn Wallis T Muhly Source Type: research
Acute Dapagliflozin Administration Ameliorates Cardiac Surgery-Associated Acute Kidney Injury in a Rabbit Model
CONCLUSIONS: Acute intravenous administration of dapagliflozin protects against CPB-induced AKI. Dapagliflozin may have direct renoprotective effects in renal tubular cells.PMID:38658352 | DOI:10.1253/circj.CJ-23-0864 (Source: Circulation Journal)
Source: Circulation Journal - April 24, 2024 Category: Cardiology Authors: Kensaku Matsuda Hiroshi Mitsuo Takuya Nishijima Hikaru Uchiyama Tobuhiro Nita Shogo Matsunaga Noriko Fujimoto Tomoki Ushijima Yusuke Ando Meikun Kan-O Gen Shinohara Satoshi Kimura Hiromichi Sonoda Akira Shiose Source Type: research
Targeting ferroptosis as a prospective therapeutic approach for diabetic nephropathy
Ann Med. 2024 Dec;56(1):2346543. doi: 10.1080/07853890.2024.2346543. Epub 2024 Apr 24.ABSTRACTDiabetic nephropathy (DN) is a severe complication of diabetes mellitus, causing a substantive threat to the public, which receives global concern. However, there are limited drugs targeting the treatment of DN. Owing to this, it is highly crucial to investigate the pathogenesis and potential therapeutic targets of DN. The process of ferroptosis is a type of regulated cell death (RCD) involving the presence of iron, distinct from autophagy, apoptosis, and pyroptosis. A primary mechanism of ferroptosis is associated with iron metab...
Source: Annals of Medicine - April 24, 2024 Category: Internal Medicine Authors: Qinrui Wu Fengjuan Huang Source Type: research
Use of sacubitril/valsartan in patients with heart failure in primary care in Germany: the AURORA-HF noninterventional study
CONCLUSION: In patients with symptomatic HFrEF treated in primary care, the group in whom Sac/Val was initiated was characterized by a higher NYHA class and lower LVEF compared to patients in whom Sac/Val was not initiated. Sac/Val was well tolerated, with a high proportion completing 1 year of therapy.PMID:38656397 | DOI:10.1007/s00059-024-05248-z (Source: Herz)
Source: Herz - April 24, 2024 Category: Cardiology Authors: Uwe Zeymer Robert Groves Stephan Hupfer Source Type: research
Vitronectin promotes insulin resistance in trophoblast cells by activating JNK in gestational diabetes mellitus
Cell Biol Int. 2024 Apr 23. doi: 10.1002/cbin.12167. Online ahead of print.ABSTRACTGestational diabetes mellitus (GDM) is a common disorder in the clinic, which may lead to severe detrimental outcomes both for mothers and infants. However, the underlying mechanisms for GDM are still not clear. In the present study, we performed label-free proteomics using placentas from GDM patients and normal controls. Vitronectin caused our attention among differentially expressed proteins due to its potential role in the pathological progression of GDM. Vitronectin was increased in the placentas of GDM patients, which was confirmed by W...
Source: Cell Biology International - April 24, 2024 Category: Cytology Authors: Yuejun Ju Ting Shen Zhanhong Guo Yinghong Kong Yun Huang Ji Hu Source Type: research
