Small cell osteosarcoma versus fusion-driven round cell sarcomas of bone: retrospective clinical, radiological, pathological, and (epi)genetic comparison with clinical implications
In conclusion, discrimination of SCOS, epigenetically related to COS, versus FDRCS of bone can be challenging but is important due to different biology and therefore therapeutic strategies. Methylation profiling is a reliable and robust diagnostic test especially on decalcified FFPE material. Subsequent fusion gene analysis and/or use of specific immunohistochemical surrogate markers can be used to substantiate the diagnosis. (Source: Virchows Archiv)
Source: Virchows Archiv - February 9, 2024 Category: Pathology Source Type: research
Cancers, Vol. 16, Pages 718: Patterns of Temporal Lobe Reaction and Radiation Necrosis after Particle Radiotherapy in Patients with Skull Base Chordoma and Chondrosarcoma & mdash;A Single-Center Experience
Conclusion: Temporal lobe reactions are a common side effect after particle therapy of the skull base. We were able to develop a multivariate model, which predicted radiation reactions with a specificity of 99% and a sensitivity of 52.2%. (Source: Cancers)
Source: Cancers - February 8, 2024 Category: Cancer & Oncology Authors: Matthias Mattke Matteo Ohlinger Nina Bougatf Robert Wolf Thomas Welzel Falk Roeder Sabine Gerum Christoph Fussl Natalee Annon-Eberharter Malte Ellerbrock Oliver J äkel Thomas Haberer Klaus Herfarth Matthias Uhl J ürgen Debus Katharina Seidensaal Semi Ha Tags: Article Source Type: research
A retrospective external validation study of the Birmingham Atypical Cartilage Tumour Imaging Protocol (BACTIP) for the management of solitary central cartilage tumours of the proximal humerus and around the knee
ConclusionAlthough promising as a useful tool for management/follow-up of CCTs of the proximal humerus, distal femur, and proximal tibia, five ACTs and one chondrosarcoma grade II were discharged, potentially inducing diagnostic delay, which could be reduced by adapting BACTIP cut-off values.Clinical relevance statementMostly, Birmingham Atypical Cartilage Tumour Imaging Protocol (BACTIP) assesses central cartilage tumours of the proximal humerus and the knee correctly. Both when using the BACTIP and when adapting cut-offs, caution should be taken for the trade-off between underdiagnosis/potential diagnostic delay in chond...
Source: European Radiology - February 6, 2024 Category: Radiology Source Type: research
Association of MiRNA and Bone Tumors: Future Therapeutic Inroads
Curr Med Chem. 2024 Jan 30. doi: 10.2174/0109298673284932231226110754. Online ahead of print.ABSTRACTSmall endogenous non-coding RNA molecules known as micro-ribonucleic acids (miRNAs) control post-transcriptional gene regulation. A change in miRNA expression is related to various diseases, including bone tumors. Benign bone tumors are categorized based on matrix production and predominant cell type. Osteochondromas and giant cell tumors are among the most common bone tumors. Interestingly, miRNAs can function as either tumor suppressor genes or oncogenes, thereby determining the fate of a tumor. In the present review, we ...
Source: Current Medicinal Chemistry - February 1, 2024 Category: Chemistry Authors: Rashid Al-Shibli Mohammed AlSuleimani Ibrahim Ahmed Abdullah Al Lawati Srijit Das Source Type: research
Successful management of a pregnancy complicated by ollier disease and coagulation factors deficiency – A rare case report
Introduction: Ollier disease (OD) is a rare, non-hereditary bone disease characterized by multiple enchondromas with a predilection for the appendicular skeleton or pelvis. Its prevalence is estimated at 1:100,000 people. Patients with OD have a 20-53% increased risk of malignant transformation into chondrosarcoma, visceral, hematologic or gonadal-related malignancies.This is the first case described in Poland and the third in the world of a pregnant patient with Ollier disease. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: Magdalena Szyde łko-Gorzkowicz, Elżbieta Poniedziałek-Czajkowska, Maciej Sotowski, Radzisław Mierzyński, Bożena Leszczyńska-Gorzelak Source Type: research
A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma
Curr Oncol. 2024 Jan 19;31(1):566-578. doi: 10.3390/curroncol31010040.ABSTRACTDedifferentiated chondrosarcoma (DDCS) is a high-grade subtype of chondrosarcoma with the bimorphic histological appearance of a conventional chondrosarcoma component with abrupt transition to a high-grade, non-cartilaginous sarcoma. DDCS can be radiographically divided into central and peripheral types. Wide resection is currently the main therapeutic option for localized DDCS. Moreover, the effectiveness of adjuvant chemotherapy remains controversial. Therefore, we performed a systematic review of available evidence to evaluate the effect of ad...
Source: Current Oncology - January 26, 2024 Category: Cancer & Oncology Authors: Shinji Tsukamoto Andreas F Mavrogenis Yuji Nitta Alberto Righi Tomoya Masunaga Kanya Honoki Hiromasa Fujii Akira Kido Yuu Tanaka Yasuhito Tanaka Costantino Errani Source Type: research
Carcinosarcoma of the parotid gland: a case report and review of the literature
ConclusionCarcinosarcoma is a high-grade aggressive lesion with a poor prognosis and should be treated aggressively. More studies are needed to understand the origin of these tumors. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - January 20, 2024 Category: General Medicine Source Type: research
The complete anterior petrosectomy: an expanded extended-middle fossa approach with removal of the infratrigeminal petrous apex and drilling of the lateral clivus
J Neurosurg. 2024 Jan 19:1-9. doi: 10.3171/2023.11.JNS231303. Online ahead of print.ABSTRACTIntradural exposure in the extended middle fossa anterior transpetrosal approach is traditionally limited to the inferior petrosal sinus inferomedially. Expanding bone removal of the petrous apex around the petrous internal carotid artery (ICA), underneath the trigeminal ganglion/mandibular nerve, and into the lateral component of the clivus can significantly expand the limits of this approach beyond the inferior petrosal sinus and allows for exposure of the midline structures, aspects of the contralateral inferior clival region, an...
Source: Journal of Neurosurgery - January 19, 2024 Category: Neurosurgery Authors: Collin Liu Alexander I Evins Travis J Atchley Daniel L Surdell William E Thorell Motonobu Nonaka Philip E Stieg Antonio Bernardo Source Type: research
Treatment strategy in laryngeal chondrosarcoma: a multicenter study of 43 cases
ConclusionThese results suggest that laryngeal preservation should be considered as the initial treatment in cases of laryngeal chondrosarcoma. (Source: European Archives of Oto-Rhino-Laryngology)
Source: European Archives of Oto-Rhino-Laryngology - January 18, 2024 Category: ENT & OMF Source Type: research
GSE184118 Single-cell RNA sequencing analysis reveals CHOP as an early marker for conventional chondrosarcoma
Contributors : Zezhuo Su ; Joshua Ho ; Kelvin CheungSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChondrosarcoma is the malignant form of chondrogenic tumors that consist of cartilage producing cells. Chondrosarcoam can arise from benign chondrogenic lesion. Benign chondrogenic tumors are normally managed conservatively, while surgical intervention can improve clinical outcomes of patients with chondrosarcoma. Clinical decision making is mainly based on the grade of the chondrogenic tumor. However, interobserver viability is high. There is currently no clear molecular for the gra...
Source: GEO: Gene Expression Omnibus - January 18, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
