The national incidence of chondrosarcoma of bone; a review
CONCLUSION: The most likely national incidence of CS of bone is between 2-4 per million per year. Three modern reports present an incidence of 3.4-4.1 per million per year.PMID:36856035 | DOI:10.1080/0284186X.2023.2177975 (Source: Acta Oncologica)
Source: Acta Oncologica - March 1, 2023 Category: Cancer & Oncology Authors: Joachim Thorkildsen Tor Åge Myklebust Source Type: research
The national incidence of chondrosarcoma of bone; a review
CONCLUSION: The most likely national incidence of CS of bone is between 2-4 per million per year. Three modern reports present an incidence of 3.4-4.1 per million per year.PMID:36856035 | DOI:10.1080/0284186X.2023.2177975 (Source: Acta Oncologica)
Source: Acta Oncologica - March 1, 2023 Category: Cancer & Oncology Authors: Joachim Thorkildsen Tor Åge Myklebust Source Type: research
The national incidence of chondrosarcoma of bone; a review
CONCLUSION: The most likely national incidence of CS of bone is between 2-4 per million per year. Three modern reports present an incidence of 3.4-4.1 per million per year.PMID:36856035 | DOI:10.1080/0284186X.2023.2177975 (Source: Acta Oncologica)
Source: Acta Oncologica - March 1, 2023 Category: Cancer & Oncology Authors: Joachim Thorkildsen Tor Åge Myklebust Source Type: research
Fibrocartilaginous mesenchymoma of pelvis —a potential diagnostic pitfall
AbstractFibrocartilaginous mesenchymoma (FM) is a rare bone tumor mimicking other fibrocartilaginous lesions on imaging and histologically. Hence, it is difficult to diagnose this entity especially on small biopsies. In this article, we report a case of FM mimicking desmoplastic fibroma on biopsy. A 36-year-old male presented with pain in the left hip. Imaging showed a large expansile lytic lesion involving the acetabulum and pubis. The differential diagnosis was suggestive of giant cell tumor, aneurysmal bone cyst, intraosseous desmoplastic fibroma, and chondrosarcoma. Biopsy revealed a low-grade spindle cell lesion with ...
Source: Skeletal Radiology - February 28, 2023 Category: Radiology Source Type: research
Development and validation of a MRI-based combined radiomics nomogram for differentiation in chondrosarcoma
ConclusionThe MRI-based combined radiomics nomogram is a noninvasive preoperative prediction tool that combines clinic-radiological feature and radiomics signature and shows good predictive effect in distinguishing low-grade and high-grade bone chondrosarcoma, which may help clinicians to make accurate treatment plans. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - February 28, 2023 Category: Cancer & Oncology Source Type: research
Extraskeletal Myxoid Chondrosarcoma:: Retrospective Case Series Examining Prognostic Factors, Treatment Approaches, and Oncologic Outcomes
CONCLUSIONS: The data in this patient series are generally consistent with published literature on EMC and demonstrate a high recurrence rate, high propensity for metastasis, and high rate of progression of metastatic disease on systemic therapy.PMID:36825763 | DOI:10.1097/COC.0000000000000988 (Source: Ann Oncol)
Source: Ann Oncol - February 24, 2023 Category: Cancer & Oncology Authors: Casey N Brodsky Matthew D Bucala Eman M Abdulfatah Geoffrey W Siegel Source Type: research
Extraskeletal Myxoid Chondrosarcoma:: Retrospective Case Series Examining Prognostic Factors, Treatment Approaches, and Oncologic Outcomes
CONCLUSIONS: The data in this patient series are generally consistent with published literature on EMC and demonstrate a high recurrence rate, high propensity for metastasis, and high rate of progression of metastatic disease on systemic therapy.PMID:36825763 | DOI:10.1097/COC.0000000000000988 (Source: Ann Oncol)
Source: Ann Oncol - February 24, 2023 Category: Cancer & Oncology Authors: Casey N Brodsky Matthew D Bucala Eman M Abdulfatah Geoffrey W Siegel Source Type: research
Atypical MRI Presentation of High-Grade Chondrosarcoma in the Proximal Femur
Teaching Point: Although magnetic resonance imaging (MRI) plays a considerable role in the detection and differentiation of chondrosarcoma (e.g., by cortical breakthrough, peritumoral soft tissue edema, and extra-osseous extension), it is important to be aware of atypical features of common bone tumors. Published on 2023-02-22 10:45:18 (Source: Journal of the Belgian Society of Radiology)
Source: Journal of the Belgian Society of Radiology - February 22, 2023 Category: Radiology Source Type: research
Correction: therapeutic effect of palbociclib in chondrosarcoma: implication of cyclin-dependent kinase 4 as a potential target
(Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2023 Category: Molecular Biology Authors: Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang and Tang Liu Tags: Correction Source Type: research
Comparison of the anti-cancer activity of 5-aminolevulinic acid-mediated photodynamic therapy after continuous wave and pulse irradiation in different histological types of canine mammary sarcoma tumors
Abstract
Canine mammary sarcoma tumors (CMST) are the most aggressive tumors with poor prognosis in dogs. Due to inadequate treatment options for CMST, recent studies have focused on alternative treatment strategies. We previously determined the optimized protocol of 5-ALA-based photodynamic therapy (PDT) in canine liposarcoma. However, its molecular mechanisms in the treatment of different histological types of CMST remain unclear.In this context, we, for the first time, assessed 5-aminolevulinic acid (5-ALA)-PDT –mediated anti-cancer activity and its molecular mechanism after continuous wave (CW) and pulse radiation...
Source: Lasers in Medical Science - February 13, 2023 Category: Laser Surgery Source Type: research
Fibrocartilaginous mesenchymoma of pelvis —a potential diagnostic pitfall
AbstractFibrocartilaginous mesenchymoma (FM) is a rare bone tumor mimicking other fibrocartilaginous lesions on imaging and histologically. Hence, it is difficult to diagnose this entity especially on small biopsies. In this article, we report a case of FM mimicking desmoplastic fibroma on biopsy. A 36-year-old male presented with pain in the left hip. Imaging showed a large expansile lytic lesion involving the acetabulum and pubis. The differential diagnosis was suggestive of giant cell tumor, aneurysmal bone cyst, intraosseous desmoplastic fibroma, and chondrosarcoma. Biopsy revealed a low-grade spindle cell lesion with ...
Source: Skeletal Radiology - February 10, 2023 Category: Radiology Source Type: research
Does PARP Inhibition Sensitize Chondrosarcoma Cell Lines to Chemotherapy or Radiotherapy? Results From a Three-dimensional Spheroid Cell Model
CONCLUSION: In our study, long-term PARP inhibition was more effective than short-term treatment, and only one of the three chondrosarcoma spheroid lines was sensitive to combined PARP inhibition and radiotherapy. These findings suggest subsequent animal studies should focus on long-term PARP inhibition, and temozolomide combined with talazoparib has a higher chance of success than combination with radiotherapy.CLINICAL RELEVANCE: Combination treatment of talazoparib and temozolomide was effective in reducing the viability of chondrosarcoma spheroids and spheroid growth, regardless of IDH mutation status, providing rationa...
Source: Clinical Orthopaedics and Related Research - February 2, 2023 Category: Orthopaedics Authors: Ieva Palubeckait ė Sanne Venneker Brendy E W M van den Akker Inge H Briaire-de Bruijn Judith V M G Bove é Source Type: research
Association Between Insurance Status and Chondrosarcoma Stage at Diagnosis in the United States: Implications for Detection and Outcomes
CONCLUSION: Being uninsured in the United States increased the odds of a late-stage diagnosis of chondrosarcoma by 94% when compared with insured patients. Lack of medical insurance presumably leads to diminished access to necessary diagnostic testing, which results in a more advanced stage at diagnosis and ultimately a worse prognosis. Efforts are required to remediate healthcare access disparities.LEVEL OF EVIDENCE: Level III.PMID:36730695 | DOI:10.5435/JAAOS-D-22-00379 (Source: The Journal of the American Academy of Orthopaedic Surgeons)
Source: The Journal of the American Academy of Orthopaedic Surgeons - February 2, 2023 Category: Orthopaedics Authors: Puja Yatham Jacklyn Garcia Valeria Fagundo Grettel Castro Pura Rodriguez de la Vega Juan G Ruiz Ana Cecilia Belzarena Source Type: research
Does PARP Inhibition Sensitize Chondrosarcoma Cell Lines to Chemotherapy or Radiotherapy? Results From a Three-dimensional Spheroid Cell Model
CONCLUSION: In our study, long-term PARP inhibition was more effective than short-term treatment, and only one of the three chondrosarcoma spheroid lines was sensitive to combined PARP inhibition and radiotherapy. These findings suggest subsequent animal studies should focus on long-term PARP inhibition, and temozolomide combined with talazoparib has a higher chance of success than combination with radiotherapy.CLINICAL RELEVANCE: Combination treatment of talazoparib and temozolomide was effective in reducing the viability of chondrosarcoma spheroids and spheroid growth, regardless of IDH mutation status, providing rationa...
Source: Cell Research - February 2, 2023 Category: Cytology Authors: Ieva Palubeckait ė Sanne Venneker Brendy E W M van den Akker Inge H Briaire-de Bruijn Judith V M G Bove é Source Type: research
Does PARP Inhibition Sensitize Chondrosarcoma Cell Lines to Chemotherapy or Radiotherapy? Results From a Three-dimensional Spheroid Cell Model
CONCLUSION: In our study, long-term PARP inhibition was more effective than short-term treatment, and only one of the three chondrosarcoma spheroid lines was sensitive to combined PARP inhibition and radiotherapy. These findings suggest subsequent animal studies should focus on long-term PARP inhibition, and temozolomide combined with talazoparib has a higher chance of success than combination with radiotherapy.CLINICAL RELEVANCE: Combination treatment of talazoparib and temozolomide was effective in reducing the viability of chondrosarcoma spheroids and spheroid growth, regardless of IDH mutation status, providing rationa...
Source: Clinical Orthopaedics and Related Research - February 2, 2023 Category: Orthopaedics Authors: Ieva Palubeckait ė Sanne Venneker Brendy E W M van den Akker Inge H Briaire-de Bruijn Judith V M G Bove é Source Type: research
