SMARCB1-Deficient Skull Base Chondrosarcoma with 12p Duplication Presenting as Somatic-Type Malignancy Arising from Metastatic Seminoma
AbstractSomatic-type malignancy (STM) can occur infrequently within a primary or metastatic testicular germ cell tumor (TGCT) and is associated with dismal prognosis and survival. STM with chondrosarcomatous features is exceedingly rare and head and neck involvement has not been previously documented. A 39-year-old white man presented with nasal obstruction and epistaxis. Imaging disclosed a 6.9-cm expansile tumor involving the nasal cavity and skull base with intraorbital and intracranial extension. The histopathologic properties of the tumor were compatible with chondrosarcoma, grade II-III. Immunohistochemically, malign...
Source: Head and Neck Pathology - January 18, 2024 Category: Pathology Source Type: research
Intratumoral and peritumoral CT radiomics in predicting prognosis in patients with chondrosarcoma: a multicenter study
ConclusionThe CT-based combined signature incorporating intratumoral and peritumoral radiomics features can predict PFS in patients with CS, which might assist clinicians in selecting individualized surveillance and treatment plans for CS patients.Critical relevance statementDevelop and validate CT-based intratumoral, peritumoral, and combined radiomics signatures to evaluate the efficacy in predicting prognosis of patients with CS.Key points• Reliable prognostic models for preoperative chondrosarcoma are lacking.• Combined radiomics signature incorporating intratumoral and peritumoral features can predict progression-...
Source: Insights into Imaging - January 17, 2024 Category: Radiology Source Type: research
Racial disparities in the management and outcomes of primary osseous neoplasms of the spine: a SEER analysis
ConclusionRace may be associated with tumor characteristics at diagnosis (including subtype, size, and site), treatment utilization, and mortality, with non-White patients having lower survival compared to White patients. Further studies are necessary to identify underlying causes of these disparities and solutions for eliminating them. (Source: Journal of Neuro-Oncology)
Source: Journal of Neuro-Oncology - January 16, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 363: Chondrosarcoma of the Femur: Is Local Recurrence Influenced by the Presence of an Extraosseous Component?
Conclusions: In CS of the femur, the presence of an extraosseous tumor component has a predictive role in LRFS, and extraosseous tumor component arising from the superior aspect was significant for decreased LRFS. Wide margins were more commonly achieved when the tumor had only an intraosseous component, and the rate of LR was significantly higher in cases with an extraosseous tumor component. When the extraosseous component arose from the superior aspect of the femur, LR occurred more frequently despite achieving adequate margins. (Source: Cancers)
Source: Cancers - January 15, 2024 Category: Cancer & Oncology Authors: Minna K. Laitinen Michael C. Parry Guy V. Morris Robert J. Grimer Vaiyapuri Sumathi Jonathan D. Stevenson Lee M. Jeys Tags: Article Source Type: research
An audit of medullary thyroid carcinoma from a tertiary care hospital in northwest India
ConclusionThis study showed that MTC comprises 3% of thyroid malignancies with a female preponderance. RET mutation-positive patients had a younger age at presentation. Surgery was the first-line therapy. Radiotherapy, TKI, and PRRT were given as a part of second-line or third-line therapy due to persistent disease and/or disease recurrence. The median PFS was better in female patients and in patients who had no residual lesions and stable disease after the primary modality of therapy. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 8, 2024 Category: Endocrinology Source Type: research
Is motherhood still possible after pelvic carbon ion radiotherapy? A promising combined fertility-preservation approach
CONCLUSION: The patient achieved optimal oncological response and delivered a healthy infant following the completion of cancer treatment.PMID:38183176 | DOI:10.1177/03008916231218794 (Source: Tumori)
Source: Tumori - January 6, 2024 Category: Cancer & Oncology Authors: Amelia Barcellini Chiara Cassani Ester Orlandi Rossella E Nappi Federica Broglia Maria Paola Delmonte Silvia Molinelli Alessandro Vai Viviana Vitolo Alessandro Gronchi Gioacchino D'Ambrosio Lorenzo Cobianchi Maria Rosaria Fiore Source Type: research
Cancers, Vol. 16, Pages 247: Grade 2, 3 and Dedifferentiated Chondrosarcomas: A Comparative Study of Isocitrate Dehydrogenase-Mutant and Wild-Type Tumors with Implications for Prognosis and Therapy
Conclusions: Grade 2, 3 and dedifferentiated chondrosarcomas are further characterized by IDH status, which in turn informs transcriptomic phenotype and overall survival. The transcriptome is distinct depending on IDH status, and implies different treatment targets. (Source: Cancers)
Source: Cancers - January 5, 2024 Category: Cancer & Oncology Authors: Karen Schoedel Tanya Heim Anette Duensing Ines Lohse Laura Presutti Rebekah Belayneh Sumail Bhogal Anya Singh-Varma Alexander Chang Uma Chandran Daniel Marker Heather Szabo-Rogers Kurt Weiss Tags: Article Source Type: research
Are IDH1 R132 Mutations Associated With Poor Prognosis in Patients With Chondrosarcoma of the Bone?
CONCLUSION: We found that IDH1 R132 mutations were negatively associated with the prognosis of patients with bone chondrosarcomas. Nevertheless, more extensive studies (such as multicenter international studies) are needed and advisable to confirm our observations in this preliminary small series. Moreover, evaluating mutational status in fresh samples instead of in paraffin-embedded sections could help to increase the number of patients with adequate DNA for analysis. If our findings will be confirmed, the evaluation of IDH mutational status in biopsy samples or resection specimens could be considered when stratifying pat...
Source: Clinical Orthopaedics and Related Research - January 3, 2024 Category: Orthopaedics Authors: Giulia Trovarelli Marta Sbaraglia Andrea Angelini Elena Bellan Elisa Pala Elisa Belluzzi Assunta Pozzuoli Chiara Borga Angelo Paolo Dei Tos Pietro Ruggieri Source Type: research
Preparation of Borrelia-Infected Mammalian Cells for Helium Ion Microscopy
Methods Mol Biol. 2024;2742:123-129. doi: 10.1007/978-1-0716-3561-2_10.ABSTRACTPreparation of mammalian cells for a Borrelia burgdorferi infection can be cumbersome especially if investigating possible cell entry processes. The initial steps of infection or entry into cells by a pathogen often involve attachment to the cell surface and plasma membrane changes. To topologically investigate with great resolution and detail these interactions of the pathogen and the mammalian cell, helium ion microscopy (HIM) can be employed. Here we describe a protocol used to define a specific multiplicity of infection (MOI) of Borrelia bur...
Source: Mol Biol Cell - January 2, 2024 Category: Molecular Biology Authors: Kati Karvonen Source Type: research
Preparation of Borrelia-Infected Mammalian Cells for Helium Ion Microscopy
Methods Mol Biol. 2024;2742:123-129. doi: 10.1007/978-1-0716-3561-2_10.ABSTRACTPreparation of mammalian cells for a Borrelia burgdorferi infection can be cumbersome especially if investigating possible cell entry processes. The initial steps of infection or entry into cells by a pathogen often involve attachment to the cell surface and plasma membrane changes. To topologically investigate with great resolution and detail these interactions of the pathogen and the mammalian cell, helium ion microscopy (HIM) can be employed. Here we describe a protocol used to define a specific multiplicity of infection (MOI) of Borrelia bur...
Source: Mol Biol Cell - January 2, 2024 Category: Molecular Biology Authors: Kati Karvonen Source Type: research
Electromyographic predictors of abducens nerve palsy after endoscopic skull base surgery
CONCLUSIONS: The presence of f-EMG activity, lack of CMAP response to stimulation, decreased CMAP amplitude, and increased CMAP onset latency were associated with immediately postoperative ANP. Long-term ANP outcomes may be associated with t-EMG parameters, including whether the nerve is able to be stimulated once identified and CMAP amplitude. Future prospective studies may be designed to standardize abducens nerve electrophysiological monitoring protocols to further refine operative and prognostic utility.PMID:38157534 | DOI:10.3171/2023.10.JNS23648 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - December 29, 2023 Category: Neurosurgery Authors: Joaquin E Jimenez Mahmoud Omar Gregory M Adams Tina Costacou Parthasarathy D Thirumala Donald J Crammond Katherine M Anetakis Jeffrey R Balzer Varun Shandal Carl H Snyderman Paul A Gardner Georgios A Zenonos Eric W Wang Source Type: research
Electromyographic predictors of abducens nerve palsy after endoscopic skull base surgery
CONCLUSIONS: The presence of f-EMG activity, lack of CMAP response to stimulation, decreased CMAP amplitude, and increased CMAP onset latency were associated with immediately postoperative ANP. Long-term ANP outcomes may be associated with t-EMG parameters, including whether the nerve is able to be stimulated once identified and CMAP amplitude. Future prospective studies may be designed to standardize abducens nerve electrophysiological monitoring protocols to further refine operative and prognostic utility.PMID:38157534 | DOI:10.3171/2023.10.JNS23648 (Source: Journal of Neurosurgery)
Source: Journal of Neurosurgery - December 29, 2023 Category: Neurosurgery Authors: Joaquin E Jimenez Mahmoud Omar Gregory M Adams Tina Costacou Parthasarathy D Thirumala Donald J Crammond Katherine M Anetakis Jeffrey R Balzer Varun Shandal Carl H Snyderman Paul A Gardner Georgios A Zenonos Eric W Wang Source Type: research
