Are IDH1 R132 Mutations Associated With Poor Prognosis in Patients With Chondrosarcoma of the Bone?

CONCLUSION: We found that IDH1 R132 mutations were negatively associated with the prognosis of patients with bone chondrosarcomas. Nevertheless, more extensive studies (such as multicenter international studies) are needed and advisable to confirm our observations in this preliminary small series. Moreover, evaluating mutational status in fresh samples instead of in paraffin-embedded sections could help to increase the number of patients with adequate DNA for analysis. If our findings will be confirmed, the evaluation of IDH mutational status in biopsy samples or resection specimens could be considered when stratifying patients, highlighting those who may benefit from more aggressive treatment (such as adjuvant chemotherapy) or closer follow-up.LEVEL OF EVIDENCE: Level III, prognostic study.PMID:38170705 | DOI:10.1097/CORR.0000000000002960

Source: Clinical Orthopaedics and Related Research - January 3, 2024 Category: Orthopaedics Authors: Giulia Trovarelli Marta Sbaraglia Andrea Angelini Elena Bellan Elisa Pala Elisa Belluzzi Assunta Pozzuoli Chiara Borga Angelo Paolo Dei Tos Pietro Ruggieri Source Type: research