Trichorhinophalangeal Syndrome Type 1–Positive Cells in Breast Dermal Granulation Tissues and Scars: A Potential Diagnostic Pitfall
Abstract: Trichorhinophalangeal syndrome type 1 (TRPS1) immunohistochemistry has been gaining popularity in recent years in the field of surgical pathology for its utility as a highly sensitive and specific marker for breast carcinomas, including those with triple-negative phenotype. More recent data suggest TRPS1 may also prove its utility in the diagnosis of mesenchymal tumors arising in the breast parenchyma, including malignant phyllodes tumors and primary chondrosarcomas and osteosarcomas of the breast. However, little is known about TRPS1 expression in nontumor cells, such as stromal fibroblasts/myofibroblasts of...
Source: The American Journal of Dermatopathology - November 26, 2022 Category: Pathology Tags: Extraordinary Case Report Source Type: research

Pulmonary blastoma that was first diagnosed as dedifferentiated chondrosarcoma using medical thoracoscopy: A case report
Rationale: Pulmonary blastoma is an extremely rare and highly aggressive tumor. Only a few hundred cases of pulmonary blastoma have been reported. In other cases, a definitive diagnosis is often made through surgical resection. The use of preoperative histopathological sampling in diagnosing was of limited value because of the variety of pulmonary blastoma histology. And there was no literature that the first biopsy was attempted with medical thoracoscopy for diagnosis. Patient concerns: A 65-year-old man presented to our hospital with pleural effusion and lung mass. Diagnoses: The patient was initially d...
Source: Medicine - November 25, 2022 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Pure proton therapy for skull base chordomas and chondrosarcomas: A systematic review of clinical experience
ConclusionsUntil now, medical centers worldwide have exerted PT to improve outcomes of skull base chordomas and chondrosarcomas. PT not combined with other radiation modalities showed favorable local control and survival with a low incidence of severe radiation-induced toxicities, which manifests promising clinical benefits. However, high-quality evidence is still limited, requiring future clinical trials and prospective studies in selected patients. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - November 25, 2022 Category: Cancer & Oncology Source Type: research

“In-house” Design and Use of 3-dimensional Printed Patient-specific Bone Tumor Resection Guides for Geometric Osteotomies in Sarcoma Surgery
We report on the successful design and use of three-dimensional printed patient-specific bone tissue resection guides in a case of proximal tibial parosteal osteosarcoma resection and reconstruction with a size-matched allograft, and in a case of a secondary pelvic chondrosarcoma resection. (Source: Techniques in Orthopaedics)
Source: Techniques in Orthopaedics - November 24, 2022 Category: Orthopaedics Tags: Special Technical Articles Source Type: research

Retroperitoneal mesenchymal chondrosarcoma with metastasis to iliac vein: A rare case report and review of the literature
In this study, we reviewed the major characteristics of ESMC and the previously reported cases, considering the rarity of these tumors. (Source: Clinical Case Reports)
Source: Clinical Case Reports - November 24, 2022 Category: General Medicine Authors: Mahsa Masjedi Esfahani, Seyed Mohammad Ali Mirazimi, Javid Azadbakht, Fatemeh Dashti Tags: CASE REPORT Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers)
Source: Cancer Biomarkers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research

Association of FBXW11 levels with tumor development and prognosis in chondrosarcoma
CONCLUSIONS: These findings establish that FBXW11 was markedly downregulated and recognized as an independent prognostic factor for patients with chondrosarcoma, and restored FBXW11 expression can suppress chondrosarcoma growth and induce apoptosis, highlighting a novel biological marker and potential therapeutic target against chondrosarcoma.PMID:36404534 | DOI:10.3233/CBM-210426 (Source: Cancer Biomarkers : Section A of Disease Markers)
Source: Cancer Biomarkers : Section A of Disease Markers - November 21, 2022 Category: Cancer & Oncology Authors: Changbao Chen Hua Zhou Xiaolin Zhang Zhongjun Liu Xinlong Ma Source Type: research