New advances in the treatment of chondrosarcoma under the PD-1/PD-L1 pathway
J Cancer Res Ther. 2024 Apr 1;20(2):522-530. doi: 10.4103/jcrt.jcrt_2269_23. Epub 2024 Apr 30.ABSTRACTBone sarcomas encompass a group of spontaneous mesenchymal malignancies, among which osteosarcoma, Ewing sarcoma, chondrosarcoma, and chordoma are the most common subtypes. Chondrosarcoma, a relatively prevalent malignant bone tumor that originates from chondrocytes, is characterized by endogenous cartilage ossification within the tumor tissue. Despite the use of aggressive treatment approaches involving extensive surgical resection, chemotherapy, and radiotherapy for patients with osteosarcoma, chondrosarcoma, and chordom...
Source: Cell Research - April 30, 2024 Category: Cytology Authors: Jiawei Yin Peng Ren Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
Composite Reconstruction With Irradiated Autograft Plus Total Hip Replacement After Type II Pelvic Resections for Tumors Is Feasible but Fraught With Complications
CONCLUSION: Composite reconstruction with extracorporeal irradiated autografts plus total hip replacement is a feasible reconstruction technique after Type II pelvic resections, although complications and reoperations were common. Although no reconstruction technique has been proven superior to other alternatives, the high risk of complications and reoperations associated with this technique should be considered when selecting from among possible alternative reconstruction methods.LEVEL OF EVIDENCE: Level IV, therapeutic study.PMID:38666740 | DOI:10.1097/CORR.0000000000003097 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - April 26, 2024 Category: Orthopaedics Authors: Arman Vahabi H üseyin Kaya Hakan Koray Tosyal ı Bur çin Keçeci D ündar Sabah Source Type: research
Tumours of the foot: A 10 years retrospective analysis
CONCLUSION: Foot tumours are relatively rare, mostly originating from soft tissue and exhibiting a benign nature. Nonetheless, a noteworthy proportion-approximately a quarter of these tumours-demonstrate malignancy. The surgical interventions undertaken in managing these tumours and associated functional outcomes generally yield acceptable results.PMID:38662594 | DOI:10.1177/10225536241248706 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - April 25, 2024 Category: Orthopaedics Authors: Vivek Ajit Singh Vinesh Sandhu Choo Tze Yong Nor Faissal Yasin Source Type: research
Tumours of the foot: A 10 years retrospective analysis
CONCLUSION: Foot tumours are relatively rare, mostly originating from soft tissue and exhibiting a benign nature. Nonetheless, a noteworthy proportion-approximately a quarter of these tumours-demonstrate malignancy. The surgical interventions undertaken in managing these tumours and associated functional outcomes generally yield acceptable results.PMID:38662594 | DOI:10.1177/10225536241248706 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - April 25, 2024 Category: Orthopaedics Authors: Vivek Ajit Singh Vinesh Sandhu Choo Tze Yong Nor Faissal Yasin Source Type: research
Tumours of the foot: A 10 years retrospective analysis
CONCLUSION: Foot tumours are relatively rare, mostly originating from soft tissue and exhibiting a benign nature. Nonetheless, a noteworthy proportion-approximately a quarter of these tumours-demonstrate malignancy. The surgical interventions undertaken in managing these tumours and associated functional outcomes generally yield acceptable results.PMID:38662594 | DOI:10.1177/10225536241248706 (Source: Journal of Orthopaedic Surgery)
Source: Journal of Orthopaedic Surgery - April 25, 2024 Category: Orthopaedics Authors: Vivek Ajit Singh Vinesh Sandhu Choo Tze Yong Nor Faissal Yasin Source Type: research
Chondrosarcoma of the Nasal Cavity and Paranasal Sinuses: A Rare Entity
Conclusions: The primary treatment for chondrosarcomas remains surgery, with a transnasal endoscopic approach offering a viable option for complete resection in select cases.PMID:38655844 | DOI:10.1177/01455613241249028 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: El Omri Malika Marwa Ben Njima Bellakhdher Mouna Nfikha Zeineb Kemani Wassim Sriha Badreddine Abdelkefi Mohamed Source Type: research
Chondrosarcoma of the Nasal Cavity and Paranasal Sinuses: A Rare Entity
Conclusions: The primary treatment for chondrosarcomas remains surgery, with a transnasal endoscopic approach offering a viable option for complete resection in select cases.PMID:38655844 | DOI:10.1177/01455613241249028 (Source: Ear, Nose and Throat Journal)
Source: Ear, Nose and Throat Journal - April 24, 2024 Category: ENT & OMF Authors: El Omri Malika Marwa Ben Njima Bellakhdher Mouna Nfikha Zeineb Kemani Wassim Sriha Badreddine Abdelkefi Mohamed Source Type: research
Oncolytic virotherapy stimulates anti ‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases
Oncol Lett. 2024 Apr 3;27(6):244. doi: 10.3892/ol.2024.14377. eCollection 2024 Jun.ABSTRACTSarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, a...
Source: Oncology Letters - April 19, 2024 Category: Cancer & Oncology Authors: Yeting Qiu Aijun Qin Ronghua Zhao Jun Ding William Wei-Guo Jia Manu Singh Yanal Murad Qian Tan Ganessan Kichenadasse Source Type: research
Oncolytic virotherapy stimulates anti ‑tumor immune response and demonstrates activity in advanced sarcoma: Report of two cases
Oncol Lett. 2024 Apr 3;27(6):244. doi: 10.3892/ol.2024.14377. eCollection 2024 Jun.ABSTRACTSarcoma is derived from mesenchymal neoplasms and has numerous subtypes, accounting for 1% of all adult malignancies and 15% of childhood malignancies. The prognosis of metastatic or recurrent sarcoma remains poor. The current study presents two cases of sarcoma enrolled in a phase I dose escalation trial for solid tumor, who had previously failed all standard therapies. These patients were treated with VG161, an immune-stimulating herpes simplex virus type 1 oncolytic virus with payloads of IL-12, IL-15 and IL-15 receptor α unit, a...
Source: Herpes - April 19, 2024 Category: Infectious Diseases Authors: Yeting Qiu Aijun Qin Ronghua Zhao Jun Ding William Wei-Guo Jia Manu Singh Yanal Murad Qian Tan Ganessan Kichenadasse Source Type: research
Malignant transformation of a solitary iliac enchondroma into a chondrosarcoma: A rare case report
Asian J Surg. 2024 Apr 11:S1015-9584(24)00615-8. doi: 10.1016/j.asjsur.2024.03.188. Online ahead of print.NO ABSTRACTPMID:38609818 | DOI:10.1016/j.asjsur.2024.03.188 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - April 12, 2024 Category: Surgery Authors: Zeyuan Lei Yong Liu Peng Mao Haihong Zhang Source Type: research
A CT-based radiomics nomogram for predicting histologic grade and outcome in chondrosarcoma
The preoperative identification of tumor grade in chondrosarcoma (CS) is crucial for devising effective treatment strategies and predicting outcomes. The study aims to build and validate a CT-based radiomics n... (Source: Cancer Imaging)
Source: Cancer Imaging - April 11, 2024 Category: Radiology Authors: Xiaoli Li, Xianglong Shi, Yanmei Wang, Jing Pang, Xia Zhao, Yuchao Xu, Qiyuan Li, Ning Wang, Feng Duan and Pei Nie Tags: Research article Source Type: research
Fibrocartilaginous Dysplasia of the Proximal Femur in Two Pediatric Patients, Including a Pathologic Fracture in a Patient With McCune-Albright Syndrome
We report the clinical presentation, imaging findings, and management of two pediatric patients with fibrocartilaginous dysplasia of the proximal femur to (1) highlight that recognition that fibrous dysplasia may contain cartilage upon frozen section will avoid overly aggressive therapy, and (2) FCD can occur in the McCune-Albright syndrome.PMID:38587471 | DOI:10.1080/15513815.2024.2320341 (Source: Fetal and Pediatric Pathology)
Source: Fetal and Pediatric Pathology - April 8, 2024 Category: Pathology Authors: Adam Haydel Randall Craver Matthew Cable Source Type: research
