GSE248490 Decoupling NAD+ metabolic dependency in chondrosarcoma by targeting the SIRT1 –HIF-2α axis
Contributors : Jooyeon Suh ; Hyeonkyeong Kim ; Jin-Hong Kim ; Yi-Jun KimSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensChondrosarcomas represent the second most common primary bone malignancy. Despite the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD+) depletion, targeting the NAD+ synthesis pathway remains challenging due to broad implications in biological processes. Here, we establish SIRT1 as a central mediator reinforcing the dependency of chondrosarcoma cells on NAD+ metabolism via HIF-2 α-mediated transcriptional reprogramming. SIRT1 knoc...
Source: GEO: Gene Expression Omnibus - December 1, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Cancers, Vol. 15, Pages 5687: Risk Factors for Radiation Necrosis and Local Recurrence after Proton Beam Therapy for Skull Base Chordoma or Chondrosarcoma
Conclusions] For skull base chordoma and chondrosarcoma, the risk factors of local recurrence were chordoma and large tumor size, and those of radiation necrosis were BED Gy10 and total dose, respectively. DVH analysis is needed to investigate the risk factors for brain necrosis in more detail. (Source: Cancers)
Source: Cancers - December 1, 2023 Category: Cancer & Oncology Authors: Mizuki Takahashi Masashi Mizumoto Yoshiko Oshiro Hiroyoshi Kino Hiroyoshi Akutsu Kei Nakai Taisuke Sumiya Eiichi Ishikawa Kazushi Maruo Hideyuki Sakurai Tags: Article Source Type: research
Cancers, Vol. 15, Pages 5579: Five-Fraction Proton Therapy for the Treatment of Skull Base Chordomas and Chondrosarcomas: Early Results of a Prospective Series and Description of a Clinical Trial
Conclusions: Hypofractionated proton therapy is showing encouraging preliminary results. However, to fully assess the efficacy of this therapeutic approach, future trials with adequate sample sizes and extended follow-ups are necessary. (Source: Cancers)
Source: Cancers - November 25, 2023 Category: Cancer & Oncology Authors: Morena Sallabanda Juan Antonio Vera Juan Mar ía Pérez Ra úl Matute Marta Montero Ana de Pablo Fernando Cerr ón Mireia Valero Juan Castro Alejandro Mazal Raymond Miralbell Tags: Article Source Type: research
Hypoxia-regulated exosomes mediate M2 macrophage polarization and promote metastasis in chondrosarcoma
In this study, we focused on the mechanism of interaction between hypoxic chondrosarcoma cells (SW1353) and macrophages. Our results suggest that hypoxia enhances the release of exosomes from chondrosarcoma cells. These hypoxia-induced exosomes promoted macrophage polarization towards the M2 phenotype, characterized by the expression of CD163 and CD206, but not the M1 phenotype, characterized by CD86 expression. Further analysis revealed that M2 macrophages polarized by exosomes expressed arginase-1 and feedback to chondrosarcoma cells to promote migration. These results suggest that chondrosarcoma cells secrete more exoso...
Source: Aging - November 22, 2023 Category: Biomedical Science Authors: Sheng-Mou Hou Chih-Yang Lin Yi-Chin Fong Chih-Hsin Tang Source Type: research
Hypoxia-regulated exosomes mediate M2 macrophage polarization and promote metastasis in chondrosarcoma
In this study, we focused on the mechanism of interaction between hypoxic chondrosarcoma cells (SW1353) and macrophages. Our results suggest that hypoxia enhances the release of exosomes from chondrosarcoma cells. These hypoxia-induced exosomes promoted macrophage polarization towards the M2 phenotype, characterized by the expression of CD163 and CD206, but not the M1 phenotype, characterized by CD86 expression. Further analysis revealed that M2 macrophages polarized by exosomes expressed arginase-1 and feedback to chondrosarcoma cells to promote migration. These results suggest that chondrosarcoma cells secrete more exoso...
Source: Aging - November 22, 2023 Category: Biomedical Science Authors: Sheng-Mou Hou Chih-Yang Lin Yi-Chin Fong Chih-Hsin Tang Source Type: research
Hypoxia-regulated exosomes mediate M2 macrophage polarization and promote metastasis in chondrosarcoma
In this study, we focused on the mechanism of interaction between hypoxic chondrosarcoma cells (SW1353) and macrophages. Our results suggest that hypoxia enhances the release of exosomes from chondrosarcoma cells. These hypoxia-induced exosomes promoted macrophage polarization towards the M2 phenotype, characterized by the expression of CD163 and CD206, but not the M1 phenotype, characterized by CD86 expression. Further analysis revealed that M2 macrophages polarized by exosomes expressed arginase-1 and feedback to chondrosarcoma cells to promote migration. These results suggest that chondrosarcoma cells secrete more exoso...
Source: Aging - November 22, 2023 Category: Biomedical Science Authors: Sheng-Mou Hou Chih-Yang Lin Yi-Chin Fong Chih-Hsin Tang Source Type: research
Is total-body MRI useful as a screening tool to rule out malignant progression in patients with multiple osteochondromas? Results in a single-center cohort of 319 adult patients
ConclusionTB-MRI can identify malignant transformation of osteochondromas in HMO patients. All peripheral chondrosarcomas occurred in flat bones (ribs, scapula, pelvis) in our study. TB-MRI might assist in triage between higher risk patients with a high burden of OC, including the location of OC in main flat bones vs lower risk patients without OC of the flat bones. (Source: Skeletal Radiology)
Source: Skeletal Radiology - November 20, 2023 Category: Radiology Source Type: research
Proton Therapy for Skull Base Chondrosarcoma
J Neurol Surg Rep 2023; 84: e144-e145 DOI: 10.1055/a-2192-5775Chondrosarcoma is a type of an endochondral bone malignancy that is primarily treated surgically with radiation therapy used in the adjuvant setting or in cases of unresectable disease. Proton therapy has potential advantages compared with traditional photon therapy for the treatment of tumors in close proximity to critical structures due to the theoretic lower exit dose. Studies have shown improved survival in patients with skull base chondrosarcoma who undergo proton therapy. However, there is a lack of randomized data. Further studies are needed to define the...
Source: Journal of Neurological Surgery Reports - November 20, 2023 Category: Neurosurgery Authors: Tang, Dennis M. Cutri, Raffaello M. Wu, Arthur W. Patil, Chirag Zumsteg, Zachary S. Tags: Skull Base Oncology Case Series Source Type: research
Acute growth of chondrosarcoma of the pelvis in a young male ：A case report
Asian J Surg. 2023 Nov 15:S1015-9584(23)01771-2. doi: 10.1016/j.asjsur.2023.11.040. Online ahead of print.NO ABSTRACTPMID:37977927 | DOI:10.1016/j.asjsur.2023.11.040 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 17, 2023 Category: Surgery Authors: Yue Xie Jianmin Song Source Type: research
Acute growth of chondrosarcoma of the pelvis in a young male ：A case report
Asian J Surg. 2023 Nov 15:S1015-9584(23)01771-2. doi: 10.1016/j.asjsur.2023.11.040. Online ahead of print.NO ABSTRACTPMID:37977927 | DOI:10.1016/j.asjsur.2023.11.040 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - November 17, 2023 Category: Surgery Authors: Yue Xie Jianmin Song Source Type: research
Cancers, Vol. 15, Pages 5294: The Role of Macrophages in Sarcoma Tumor Microenvironment and Treatment
wski
Sarcomas are a heterogeneous group of malignant mesenchymal tumors, including soft tissue and bone sarcomas. Macrophages in the tumor microenvironment, involved in immunosuppression and leading to tumor development, are called tumor-associated macrophages (TAMs). TAMs are very important in modulating the microenvironment of sarcomas by expressing specific markers and secreting factors that influence immune and tumor cells. They are involved in many signaling pathways, such as p-STAT3/p-Erk1/2, PI3K/Akt, JAK/MAPK, and JAK/STAT3. TAMs also significantly impact the clinical outcomes of patients suffering from sarcoma...
Source: Cancers - November 5, 2023 Category: Cancer & Oncology Authors: Agnieszka E. Zaj ąc Anna M. Czarnecka Piotr Rutkowski Tags: Review Source Type: research
Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
Cancers (Basel). 2023 Oct 17;15(20):5021. doi: 10.3390/cancers15205021.ABSTRACTSkull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic and evidence-based review of the clinical outcomes of patients with skull-base chordoma and chondrosarcoma treated with carbon ion radiotherapy (CIRT). A literature review was performed using a MEDLINE search of all articles to date. We identified 227 studies as appropriate for review, and 24 were ultimately inc...
Source: Cancer Control - October 28, 2023 Category: Cancer & Oncology Authors: Adam L Holtzman Katharina Seidensaal Alberto Iannalfi Kyung Hwan Kim Masashi Koto Wan-Chin Yang Cheng-Ying Shiau Anita Mahajan Safia K Ahmed Daniel M Trifiletti Jennifer L Peterson Daniel M Koffler Laura A Vallow Bradford S Hoppe Michael S Rutenberg Source Type: research
Creation, evolution, and future challenges of ion beam therapy from a medical physicist ’s viewpoint (Part 3): Chapter 3. Clinical research, Chapter 4. Future challenges, Chapter 5. Discussion, and Conclusion
This article summarizes a series of articles (Parts 1–3) and describes future issues of immune ion beam therapy and linear energy transfer optimization. (Source: Radiological Physics and Technology)
Source: Radiological Physics and Technology - October 26, 2023 Category: Physics Source Type: research
