Canine Idiopathic Arteriopathy, Appendicular Bone Infarcts, and Neoplastic Transformation of Bone Infarcts in 108 Dogs (Canis lupus familiaris)
In this study, 653 cases of canine bone infarcts were received through a referral veterinary osteopathology service over a 14-y period. We identified an idiopathic disorder affecting the nutrient artery, termed canine idiopathic arteriopathy (CIA), which to our knowledge has no direct counterpart in human medicine. This disorder was documented alongside ischemic necrosis of the medullary cavity in 114 bone infarcts in 108 dogs. We hypothesize that CIA precipitated an ischemic environment, resulting in development of a bone infarct downstream of the abnormal artery. In 52% (59 of 114) of cases, bone infarcts demonstrated ev...
Source: Comparative Medicine - September 16, 2022 Category: Zoology Authors: Isabel A Jimenez Roy R Pool Kathleen L Gabrielson Source Type: research

Canine Idiopathic Arteriopathy, Appendicular Bone Infarcts, and Neoplastic Transformation of Bone Infarcts in 108 Dogs ( < em > Canis lupus familiaris < /em > )
In this study, 653 cases of canine bone infarcts were received through a referral veterinary osteopathology service over a 14-y period. We identified an idiopathic disorder affecting the nutrient artery, termed canine idiopathic arteriopathy (CIA), which to our knowledge has no direct counterpart in human medicine. This disorder was documented alongside ischemic necrosis of the medullary cavity in 114 bone infarcts in 108 dogs. We hypothesize that CIA precipitated an ischemic environment, resulting in development of a bone infarct downstream of the abnormal artery. In 52% (59 of 114) of cases, bone infarcts demonstrated ev...
Source: Comparative Medicine - September 16, 2022 Category: Zoology Authors: Isabel A Jimenez Roy R Pool Kathleen L Gabrielson Source Type: research

Identification of Novel PGR-NR4A3 Fusion in Extraskeletal Myxoid Chondrosarcoma and Resultant Patient Benefit From Tamoxifen Therapy
JCO Precis Oncol. 2022 Aug;6:e2200039. doi: 10.1200/PO.22.00039.NO ABSTRACTPMID:36103645 | DOI:10.1200/PO.22.00039 (Source: Ann Oncol)
Source: Ann Oncol - September 14, 2022 Category: Cancer & Oncology Authors: H Catherine Wilbur Dan R Robinson Yi-Mi Wu Chandan Kumar-Sinha Arul M Chinnaiyan Rashmi Chugh Source Type: research

The Effects and Mechanisms of Sennoside A on Inducing Cytotoxicity, Apoptosis, and Inhibiting Metastasis in Human Chondrosarcoma Cells
Evid Based Complement Alternat Med. 2022 Aug 31;2022:8063497. doi: 10.1155/2022/8063497. eCollection 2022.ABSTRACTCurrently, developing therapeutic strategies for chondrosarcoma (CS) remains important. Sennoside A (SA), a dianthrone glycoside from Senna and Rhubarb, is widely used as an irritant laxative, weight-loss agent, or dietary supplement, which possesses various bioactive properties such as laxative, antiobesity, and hypoglycemic activities. For the first time, our results suggested that cell proliferation and metastasis were inhibited by SA in CS SW1353 cells. SA induced cell growth arrest by inhibiting cell proli...
Source: Evidence-based Complementary and Alternative Medicine - September 12, 2022 Category: Complementary Medicine Authors: Jiamei Le Houlin Ji Peixian Pi Kaijie Chen Xuefeng Gu Yujie Ma Yi Fu Yongning Sun Xiaoxiao Zhou Hailong Wu Source Type: research

Laryngeal chondrosarcoma treated with conventional radiotherapy - case report and review of the literature
We report a case of a 68-year-old patient with laryngeal chondrosarcoma, whose first symptoms were hoarseness and gradually increasing dyspnoea, but there was no sign of disease in clinical examination, which postponed the diagnosis. The patient underwent complete laryngectomy and adjuvant conformal radiotherapy with a total dose of 70 Gy. The pathological assessment confirmed advanced laryngeal chondrosarcoma originating from thyroid cartilage. Imaging studies and directoscopy were performed, and they did not reveal recurrence or metastases of the disease for 6 years. Distant metastatic spread in the liver and lungs was c...
Source: Polish Journal of Pathology - September 8, 2022 Category: Pathology Authors: Agata Roch-Zniszczo ł Dorota Ksi ężniak-Baran Ewa Chmielik Maria Gole ń Natalia Amrogowicz Dorota Gabry ś Source Type: research

Laryngeal chondrosarcoma treated with conventional radiotherapy - case report and review of the literature
We report a case of a 68-year-old patient with laryngeal chondrosarcoma, whose first symptoms were hoarseness and gradually increasing dyspnoea, but there was no sign of disease in clinical examination, which postponed the diagnosis. The patient underwent complete laryngectomy and adjuvant conformal radiotherapy with a total dose of 70 Gy. The pathological assessment confirmed advanced laryngeal chondrosarcoma originating from thyroid cartilage. Imaging studies and directoscopy were performed, and they did not reveal recurrence or metastases of the disease for 6 years. Distant metastatic spread in the liver and lungs was c...
Source: Polish Journal of Pathology - September 8, 2022 Category: Pathology Authors: Agata Roch-Zniszczo ł Dorota Ksi ężniak-Baran Ewa Chmielik Maria Gole ń Natalia Amrogowicz Dorota Gabry ś Source Type: research

Differentiation of Skull Base Chondrosarcomas, Chordomas, and Metastases: Utility of DWI and Dynamic Contrast-Enhanced Perfusion MR Imaging [FUNCTIONAL]
CONCLUSIONS: DWI and dynamic contrast-enhanced MR imaging sequences can be beneficial for differentiating the 3 common skull base tumors. (Source: American Journal of Neuroradiology)
Source: American Journal of Neuroradiology - September 7, 2022 Category: Radiology Authors: Ota, Y., Liao, E., Capizzano, A. A., Baba, A., Kurokawa, R., Kurokawa, M., Srinivasan, A. Tags: FUNCTIONAL Source Type: research

Lumbopelvic shortening and local host bone-to-host bone reconstruction: a surgical method for lumbopelvic fusion following total sacrectomy
ConclusionPrimary lumbopelvic shortening represents an alternative local autograft reconstructive technique for management of large sacral defects following total sacrectomy. This technique obviates the additional morbidity and surgical cost associated with the use of previously described techniques. (Source: European Spine Journal)
Source: European Spine Journal - September 3, 2022 Category: Orthopaedics Source Type: research

Chondroitin sulfate proteoglycan 4 expression in chondrosarcoma: A potential target for antibody-based immunotherapy
Chondrosarcoma is a common primary bone malignancy whose phenotype increases with its histologic grade. They are relatively resistant to chemotherapy and radiation therapy limiting curative options for disseminated disease. Chondroitin sulfate proteoglycan 4 (CSPG4) is a cell surface proteoglycan that is highly expressed across various human cancers, including chondrosarcoma, and has restricted distribution in healthy tissues, making it an attractive target for the antibody-based therapy. CSPG4 specific chimeric antigen receptor (CAR) T cell therapies have been shown to be effective in treating other cancers such as melano...
Source: Frontiers in Oncology - August 30, 2022 Category: Cancer & Oncology Source Type: research

A genetic model for central chondrosarcoma evolution correlates with patient outcome
ConclusionsTumours withIDH1 orIDH2 mutations or those that areIDHwt have significantly different genetic pathways and outcomes in relation toTERT mutation. Diagnostic testing forIDH1,IDH2, andTERT mutations could therefore help to guide clinical monitoring and prognostication. (Source: Genome Medicine)
Source: Genome Medicine - August 30, 2022 Category: Genetics & Stem Cells Source Type: research

Primary thyroid chondrosarcoma: a case report of an extremely rare malignancy
CONCLUSION: Chondrosarcoma of the thyroid gland is extremely rare either in the primary or metastatic setting. Although the prognosis is bad, surgery is the main line of treatment after early prompt diagnosis.PMID:36031648 | DOI:10.1186/s43046-022-00138-z (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - August 28, 2022 Category: Cancer & Oncology Authors: Shadi Awny Mohammad Zuhdy Omar Hamdy Gehad Ahmad Saleh Ahmed Hassan Mohamed Abdelkhalek Amir Mosaad Mohamed T Hafez Sameh Roshdy Ahmed Setit Nirmeen Megahed Source Type: research

Primary thyroid chondrosarcoma: a case report of an extremely rare malignancy
CONCLUSION: Chondrosarcoma of the thyroid gland is extremely rare either in the primary or metastatic setting. Although the prognosis is bad, surgery is the main line of treatment after early prompt diagnosis.PMID:36031648 | DOI:10.1186/s43046-022-00138-z (Source: J Egypt Natl Canc In...)
Source: J Egypt Natl Canc In... - August 28, 2022 Category: Cancer & Oncology Authors: Shadi Awny Mohammad Zuhdy Omar Hamdy Gehad Ahmad Saleh Ahmed Hassan Mohamed Abdelkhalek Amir Mosaad Mohamed T Hafez Sameh Roshdy Ahmed Setit Nirmeen Megahed Source Type: research