Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1
Immunology. 2024 Mar 5. doi: 10.1111/imm.13775. Online ahead of print.ABSTRACTIn 2015, the oncolytic herpes simplex virus 1 (HSV-1) T-VEC (talimogene laherparepvec) was approved for intratumoral injection in non-resectable malignant melanoma. To determine whether viral replication is required for oncolytic activity, we compared replication-deficient HSV-1 d106S with replication-competent T-VEC. High infectious doses of HSV-1 d106S killed melanoma (n = 10), head-and-neck squamous cell carcinoma (n = 11), and chondrosarcoma cell lines (n = 2) significantly faster than T-VEC as measured by MTT metabolic activity, while low do...
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Georg Lindner Annika Walter Clara L Magnus Katharina Rosenhammer Bohdan Holoborodko Victoria Koch Sarah Hirsch Luis Grossmann Suqi Li David M Knipe Neal DeLuca Beatrice Schuler-Thurner Stefanie Gross Barbara Schwertner Martina Toelge Anette Rohrhofer Sabi Source Type: research
CORR Insights ®: Are IDH1 R132 Mutations Associated With Poor Prognosis in Patients With Chondrosarcoma of the Bone?
Clin Orthop Relat Res. 2024 Mar 6. doi: 10.1097/CORR.0000000000003019. Online ahead of print.NO ABSTRACTPMID:38446419 | DOI:10.1097/CORR.0000000000003019 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - March 6, 2024 Category: Orthopaedics Authors: Duncan C Ramsey Source Type: research
Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1
Immunology. 2024 Mar 5. doi: 10.1111/imm.13775. Online ahead of print.ABSTRACTIn 2015, the oncolytic herpes simplex virus 1 (HSV-1) T-VEC (talimogene laherparepvec) was approved for intratumoral injection in non-resectable malignant melanoma. To determine whether viral replication is required for oncolytic activity, we compared replication-deficient HSV-1 d106S with replication-competent T-VEC. High infectious doses of HSV-1 d106S killed melanoma (n = 10), head-and-neck squamous cell carcinoma (n = 11), and chondrosarcoma cell lines (n = 2) significantly faster than T-VEC as measured by MTT metabolic activity, while low do...
Source: Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Georg Lindner Annika Walter Clara L Magnus Katharina Rosenhammer Bohdan Holoborodko Victoria Koch Sarah Hirsch Luis Grossmann Suqi Li David M Knipe Neal DeLuca Beatrice Schuler-Thurner Stefanie Gross Barbara Schwertner Martina Toelge Anette Rohrhofer Sabi Source Type: research
Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1
Immunology. 2024 Mar 5. doi: 10.1111/imm.13775. Online ahead of print.ABSTRACTIn 2015, the oncolytic herpes simplex virus 1 (HSV-1) T-VEC (talimogene laherparepvec) was approved for intratumoral injection in non-resectable malignant melanoma. To determine whether viral replication is required for oncolytic activity, we compared replication-deficient HSV-1 d106S with replication-competent T-VEC. High infectious doses of HSV-1 d106S killed melanoma (n = 10), head-and-neck squamous cell carcinoma (n = 11), and chondrosarcoma cell lines (n = 2) significantly faster than T-VEC as measured by MTT metabolic activity, while low do...
Source: Herpes - March 6, 2024 Category: Infectious Diseases Authors: Georg Lindner Annika Walter Clara L Magnus Katharina Rosenhammer Bohdan Holoborodko Victoria Koch Sarah Hirsch Luis Grossmann Suqi Li David M Knipe Neal DeLuca Beatrice Schuler-Thurner Stefanie Gross Barbara Schwertner Martina Toelge Anette Rohrhofer Sabi Source Type: research
CORR Insights ®: Are IDH1 R132 Mutations Associated With Poor Prognosis in Patients With Chondrosarcoma of the Bone?
Clin Orthop Relat Res. 2024 Mar 6. doi: 10.1097/CORR.0000000000003019. Online ahead of print.NO ABSTRACTPMID:38446419 | DOI:10.1097/CORR.0000000000003019 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - March 6, 2024 Category: Orthopaedics Authors: Duncan C Ramsey Source Type: research
Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1
Immunology. 2024 Mar 5. doi: 10.1111/imm.13775. Online ahead of print.ABSTRACTIn 2015, the oncolytic herpes simplex virus 1 (HSV-1) T-VEC (talimogene laherparepvec) was approved for intratumoral injection in non-resectable malignant melanoma. To determine whether viral replication is required for oncolytic activity, we compared replication-deficient HSV-1 d106S with replication-competent T-VEC. High infectious doses of HSV-1 d106S killed melanoma (n = 10), head-and-neck squamous cell carcinoma (n = 11), and chondrosarcoma cell lines (n = 2) significantly faster than T-VEC as measured by MTT metabolic activity, while low do...
Source: Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Georg Lindner Annika Walter Clara L Magnus Katharina Rosenhammer Bohdan Holoborodko Victoria Koch Sarah Hirsch Luis Grossmann Suqi Li David M Knipe Neal DeLuca Beatrice Schuler-Thurner Stefanie Gross Barbara Schwertner Martina Toelge Anette Rohrhofer Sabi Source Type: research
CORR Insights ®: Are IDH1 R132 Mutations Associated With Poor Prognosis in Patients With Chondrosarcoma of the Bone?
Clin Orthop Relat Res. 2024 Mar 6. doi: 10.1097/CORR.0000000000003019. Online ahead of print.NO ABSTRACTPMID:38446419 | DOI:10.1097/CORR.0000000000003019 (Source: Clinical Orthopaedics and Related Research)
Source: Clinical Orthopaedics and Related Research - March 6, 2024 Category: Orthopaedics Authors: Duncan C Ramsey Source Type: research
ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair
CONCLUSION: Our results indicate that HTB94 cells were likely more efficient in DNA repair than AG01522 cells, specifically via ATR signaling, which inhibited the bystander signal-induced MN formation. This study highlights the significance of DNA repair efficiency in bystander cell responses.PMID:38442236 | DOI:10.1080/09553002.2024.2324479 (Source: International Journal of Radiation Biology)
Source: International Journal of Radiation Biology - March 5, 2024 Category: Radiology Authors: Nho Cong Luong Hidemasa Kawamura Hiroko Ikeda Reiko T Roppongi Atsushi Shibata Jiaxuan Hu Jinmeng G Jiang David S Yu Kathryn D Held Source Type: research
Evaluation of cranial nerve involvement in chordomas and chondrosarcomas: a retrospective imaging study
ConclusionThe incidence of CNI and off-midline location in chondrosarcomas was significantly higher than that in chordomas. CNI, tumor location, and the mean ADC can help distinguish between these entities. (Source: Neuroradiology)
Source: Neuroradiology - February 26, 2024 Category: Radiology Source Type: research
A meta ‐analysis comparing efficacy and safety between proton beam therapy versus carbon ion radiotherapy
ConclusionThis study highlighted the comparability of PBT and CIRT in terms of oncological outcomes and adverse events. (Source: Cancer Medicine)
Source: Cancer Medicine - February 24, 2024 Category: Cancer & Oncology Authors: Jeong Yun Jang,
Kangpyo Kim,
Miao ‐Fen Chen,
Tetsuo Akimoto,
Michael Lian Chek Wang,
Min‐Ji Kim,
Kyunga Kim,
Tae Hoon Lee,
Gyu Sang Yoo,
Hee Chul Park Tags: RESEARCH ARTICLE Source Type: research
Cancers, Vol. 16, Pages 856: Skull-Base Chondrosarcoma: A Systematic Review of the Role of Postoperative Radiotherapy
This study searched the EMBASE, Cochrane, and PubMed databases for clinical studies evaluating the long-term prognosis of surgery with or without adjuvant radiotherapy. After reviewing the search results, a total of 22 articles were selected for this review. A total of 1388 patients were included in this cohort, of which 186 received surgery only. With mean follow-up periods ranging from 39.1 to 86 months, surgical treatment provided progression-free survival (PFS) rates ranging from 83.7 to 92.9% at 3 years, 60.0 to 92.9% at 5 years, and 58.2 to 64.0% at 10 years. Postoperative radiotherapy provides PFS rates ranging betw...
Source: Cancers - February 21, 2024 Category: Cancer & Oncology Authors: Pawan Kishore Ravindran Max E. Keizer Henricus (Dirk) P. M. Kunst Inge Compter Jasper Van Aalst Dani ëlle B. P. Eekers Yasin Temel Tags: Systematic Review Source Type: research
Efficient gene delivery by multifunctional star poly ( β-amino ester)s into difficult-to-transfect macrophages for M1 polarization
J Control Release. 2024 Feb 15:S0168-3659(24)00111-1. doi: 10.1016/j.jconrel.2024.02.024. Online ahead of print.ABSTRACTGene delivery to macrophages holds great promise for cancer immunotherapy. However, traditional gene delivery methods exhibit low transfection efficiency in macrophages. The star-shaped topological structure of polymers is known to encapsulate genes inside their cores, thereby facilitating sustained release of the genetic material. Herein, combining the structural advantages of star polymers and the transfection advantages of poly (β-amino ester)s (PAEs), we developed a novel linear oligomer grafting-ont...
Source: Cancer Control - February 17, 2024 Category: Cancer & Oncology Authors: Tao Bo Chenfei Wang Dingjin Yao Qiuyu Jiang Yitong Zhao Feifei Wang Wei He Weiyi Xu Hao Zhou Ming Li Si Zhang Ruyi Xue Source Type: research
Innovative Technique of Chest Wall Reconstruction After Extensive Tumour Ablation Surgery
AbstractChest wall reconstruction is among one of the most challenging surgeries because the defect comprises multiple components and each needs to be reconstructed separately with like tissues. Chest wall reconstruction ranges from simple skin cover to complex bony and or mediastinal/precordial reconstruction. Various methods of reconstruction include autologous as well alloplastic techniques. Autologous techniques include regional or distant flaps with or without bone. Whereas alloplastic techniques include the placement of a variety of implant materials like titanium plate/mesh, stainless steel mesh, medpore and biocomp...
Source: Indian Journal of Surgical Oncology - February 15, 2024 Category: Cancer & Oncology Source Type: research
Genes, Vol. 15, Pages 242: FGF23 Expression Is a Promising Immunohistochemical Diagnostic Marker for Undifferentiated Pleomorphic Sarcoma of Bone (UPSb)
Conclusions: The results we present here suggest that FGF23 immunohistochemistry may be a useful tool to aid in differentiating UPSb from morphologically similar malignant bone sarcomas, especially in situations where sampling is restricted and there is limited clinical information available. (Source: Genes)
Source: Genes - February 14, 2024 Category: Genetics & Stem Cells Authors: Al-Hassi Ali Cooke De Silva Brini Babu Sumathi Morris Niada Tags: Article Source Type: research
