Complications and local recurrence of chondrosarcoma and chordoma treated by total tumor resection in thoracic and lumbar spine
En bloc resection of spinal tumors is challenging and associated with a high incidence of complications; however, it offers the potential to reduce the risk of recurrence when a wide margin is achieved. This r... (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - March 26, 2024 Category: Orthopaedics Authors: Jiacheng Liu, Panpan Hu, Zhongjun Liu and Feng Wei Tags: Research Source Type: research
Intercalary Resection of the Tibia for Primary Bone Tumors: Are Vascularized Fibula Autografts With or Without Allografts a Durable Reconstruction?
CONCLUSION: VFG, alone or combined with an allograft, could be considered in reconstructing a lower extremity after intercalary resections of the tibia for primary bone tumors, and it avoids the use of a large endoprosthesis. However, this procedure was associated with frequent, often severe complications during the first postoperative years and complication-free survival of 58% at 5 years. Nearly 10% of patients ultimately had an amputation. For patients whose reconstruction succeeded, the technique provides a durable reconstruction with good MSTS scores, and we believe it is useful for active patients with long life expe...
Source: Cell Research - March 21, 2024 Category: Cytology Authors: Domenico Andrea Campanacci Roberto Scanferla Mariagrazia Marsico Federico Scolari Guido Scoccianti Giovanni Beltrami Luca Delcroix Marco Innocenti Rodolfo Capanna Source Type: research
Intercalary Resection of the Tibia for Primary Bone Tumors: Are Vascularized Fibula Autografts With or Without Allografts a Durable Reconstruction?
CONCLUSION: VFG, alone or combined with an allograft, could be considered in reconstructing a lower extremity after intercalary resections of the tibia for primary bone tumors, and it avoids the use of a large endoprosthesis. However, this procedure was associated with frequent, often severe complications during the first postoperative years and complication-free survival of 58% at 5 years. Nearly 10% of patients ultimately had an amputation. For patients whose reconstruction succeeded, the technique provides a durable reconstruction with good MSTS scores, and we believe it is useful for active patients with long life expe...
Source: Clinical Orthopaedics and Related Research - March 21, 2024 Category: Orthopaedics Authors: Domenico Andrea Campanacci Roberto Scanferla Mariagrazia Marsico Federico Scolari Guido Scoccianti Giovanni Beltrami Luca Delcroix Marco Innocenti Rodolfo Capanna Source Type: research
Intercalary Resection of the Tibia for Primary Bone Tumors: Are Vascularized Fibula Autografts With or Without Allografts a Durable Reconstruction?
CONCLUSION: VFG, alone or combined with an allograft, could be considered in reconstructing a lower extremity after intercalary resections of the tibia for primary bone tumors, and it avoids the use of a large endoprosthesis. However, this procedure was associated with frequent, often severe complications during the first postoperative years and complication-free survival of 58% at 5 years. Nearly 10% of patients ultimately had an amputation. For patients whose reconstruction succeeded, the technique provides a durable reconstruction with good MSTS scores, and we believe it is useful for active patients with long life expe...
Source: Cell Research - March 21, 2024 Category: Cytology Authors: Domenico Andrea Campanacci Roberto Scanferla Mariagrazia Marsico Federico Scolari Guido Scoccianti Giovanni Beltrami Luca Delcroix Marco Innocenti Rodolfo Capanna Source Type: research
Intercalary Resection of the Tibia for Primary Bone Tumors: Are Vascularized Fibula Autografts With or Without Allografts a Durable Reconstruction?
CONCLUSION: VFG, alone or combined with an allograft, could be considered in reconstructing a lower extremity after intercalary resections of the tibia for primary bone tumors, and it avoids the use of a large endoprosthesis. However, this procedure was associated with frequent, often severe complications during the first postoperative years and complication-free survival of 58% at 5 years. Nearly 10% of patients ultimately had an amputation. For patients whose reconstruction succeeded, the technique provides a durable reconstruction with good MSTS scores, and we believe it is useful for active patients with long life expe...
Source: Clinical Orthopaedics and Related Research - March 21, 2024 Category: Orthopaedics Authors: Domenico Andrea Campanacci Roberto Scanferla Mariagrazia Marsico Federico Scolari Guido Scoccianti Giovanni Beltrami Luca Delcroix Marco Innocenti Rodolfo Capanna Source Type: research
DNM3OS/miR-127-5p/CDH11, activates Wnt3a/ β-catenin/LEF-1 pathway to form a positive feedback and aggravate spine facet joint osteoarthritis
In this study, spine facet joint tissue of patients were collected. In vitro and in vivo models were constructed with SW1353 cells and rats. Hematoxylin and eosin (HE) staining, Safranin O-fast Green, Alcian blue staining, and Tolueine blue O (TBO) staining were employed for histology analyses. Quantitative PCR, western blotting, and Immunofluorescence were performed to evaluate the expression of genes. The levels of inflammatory cytokines were measured by enzyme-linked immunosorbent assay analysis. Cell Counting Kit-8 and flow cytometry were used for cell activity and apoptosis evaluation. The targeting sites between micr...
Source: Cell Research - March 20, 2024 Category: Cytology Authors: Jing Wang Zhenyu Yang Xiuming He Yeyang Wang Dixin Luo Wangyang Xu Hongtao Zhang Xiaozhong Zhou Source Type: research
A systematic review and meta-analysis of radiotherapy and particle beam therapy for skull base chondrosarcoma: TRP-chondrosarcoma 2024
ConclusionPT for skull base chondrosarcoma had a good outcome and may be a valuable option among radiotherapy modalities. However, high-dose postoperative irradiation of skull base chondrosarcoma can cause adverse events such as temporal lobe necrosis. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - March 19, 2024 Category: Cancer & Oncology Source Type: research
Undifferentiated High-Grade Pleomorphic Bone Sarcoma: A Case Report
In this study, a case of undifferentiated high-grade pleomorphic bone sarcoma located in the distal femur was reported. It aimed to discuss the patient ’s clinical presentation, diagnostic approach, treatment, and follow-up process in light of the literature. In this case, the tumor was resected with wide margins after neoadjuvant chemotherapy. He died of diffuse lung metastases during the adjuvant chemotherapy process. Unlike the literature, the patient was only 29 years old. The patient died 8 months after the first diagnosis. (Source: Indian Journal of Surgical Oncology)
Source: Indian Journal of Surgical Oncology - March 19, 2024 Category: Cancer & Oncology Source Type: research
Does the presence of macroscopic intralesional fat exclude malignancy? An analysis of 613 histologically proven malignant bone lesions
ConclusionMalignant lesions rarely contain macroscopic intralesional fat on CT or MRI. While CT is effective in detecting macroscopic intralesional fat in primarily lytic lesions, MRI may be better for the assessment of heterogenous and infiltrative lesions with mixed lytic and sclerotic components.Clinical relevance statementMacroscopic intralesional fat is rarely seen in malignant bone tumors and its presence can help to guide the diagnostic workup of bone lesions.Key Points•Presence of macroscopic intralesional fat in bone lesions has been widely theorized as a sign of benignity, but there is limited supporting eviden...
Source: European Radiology - March 15, 2024 Category: Radiology Source Type: research
An innovative reconstruction of an enbloc resected composite giant chest and abdominal wall chondrosarcoma with 3D-composite mesh
Chest wall chondrosarcomas, although common, pose unique challenges due to their aggressive nature, rarity of abdominal wall involvement, and propensity for recurrence. We highlight the critical role of meticu... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - March 14, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Klein Dantis, Ramandeep Singh, Archit Goel and Brijesh Garg Tags: Case Report Source Type: research
GSE235701 A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma
Series Type : Expression profiling by high throughput sequencing ; Methylation profiling by genome tiling arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Methylation profiling by genome tiling array Homo sapiens Source Type: research
GSE235697 A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma [Illumina_methylation]
Contributors : V Rey ; J Tornin ; J J Alba-Linares ; C Robledo ; D Murillo ; A Rodriguez ; B Galego ; C Huergo ; A Bra ña ; A Astudillo ; D Heymann ; K Szuhai ; J Bovée ; A Fernandez ; M Fraga ; J Alonso ; R RodriguezSeries Type : Methylation profiling by genome tiling arrayOrganism : Homo sapiensThe heterogenous genomic nature of most sarcoma subtypes makes them especially indicated for personalized treatment approaches. Here, we developed a personalized medicine strategy based in the use of patient-derived cell lines as a drug-testing platform. Targeted sequencing of a panel of cancer-related genes in t...
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Methylation profiling by genome tiling array Homo sapiens Source Type: research
GSE235605 A personalized medicine approach identifies enasidenib as an efficient treatment for IDH2 mutant chondrosarcoma [RNAseq_Enasidenib]
Contributors : V Rey ; J Tornin ; J J Alba-Linares ; C Robledo ; D Murillo ; A Rodriguez ; B Galego ; C Huergo ; A Bra ña ; A Astudillo ; D Heymann ; K Szuhai ; J Bovée ; A Fernandez ; M Fraga ; J Alonso ; R RodriguezSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe heterogenous genomic nature of most sarcoma subtypes makes them especially indicated for personalized treatment approaches. Here, we developed a personalized medicine strategy based in the use of patient-derived cell lines as a drug-testing platform. Targeted sequencing of a panel of cancer-related gene...
Source: GEO: Gene Expression Omnibus - March 11, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Development of Injectable Thermosensitive Nanocomposite Hydrogel for Ratiometric Drug Delivery to Treat Drug Resistant Chondrosarcoma In Vivo
A radiometric nanocomposite hydrogel capable of co-delivering Doxorubicin and the Bcl-2 inhibitor ABT-737 is engineered, employing an optimized drug ratio of 5:1 (w/w) suitable for both in vitro and in vivo applications. The findings reveals a synergistic tumor inhibition effect with the co-delivery hydrogel. This innovative approach presents a transformative strategy for addressing drug resistance in chondrosarcoma chemotherapy, holding substantial promise for clinical applications. AbstractChondrosarcoma(CS), a prevalent primary malignant bone tumor, frequently exhibits chemotherapy resistance attributed to upregulated a...
Source: Small - March 8, 2024 Category: Nanotechnology Authors: Jiahui Zhu,
Ran Wei,
Guang Hu,
Hui Wang,
Wenbin Wang,
Haiqiang Wang,
Jidan Huang,
Yu Wang,
Yujing Li,
Huan Meng Tags: Research Article Source Type: research
Comparison of the oncolytic activity of a replication-competent and a replication-deficient herpes simplex virus 1
Immunology. 2024 Mar 5. doi: 10.1111/imm.13775. Online ahead of print.ABSTRACTIn 2015, the oncolytic herpes simplex virus 1 (HSV-1) T-VEC (talimogene laherparepvec) was approved for intratumoral injection in non-resectable malignant melanoma. To determine whether viral replication is required for oncolytic activity, we compared replication-deficient HSV-1 d106S with replication-competent T-VEC. High infectious doses of HSV-1 d106S killed melanoma (n = 10), head-and-neck squamous cell carcinoma (n = 11), and chondrosarcoma cell lines (n = 2) significantly faster than T-VEC as measured by MTT metabolic activity, while low do...
Source: Immunology - March 6, 2024 Category: Allergy & Immunology Authors: Georg Lindner Annika Walter Clara L Magnus Katharina Rosenhammer Bohdan Holoborodko Victoria Koch Sarah Hirsch Luis Grossmann Suqi Li David M Knipe Neal DeLuca Beatrice Schuler-Thurner Stefanie Gross Barbara Schwertner Martina Toelge Anette Rohrhofer Sabi Source Type: research
