Forequarter Amputation for Malignant Tumours: Tale of Sustained Relevance or Telltale Sign of Doom?
AbstractForequarter amputation (interscapulothoracic amputation) includes surgical removal of an upper limb and the shoulder girdle, including the scapula and a portion of the clavicle. We aim to report about our recent experience of having to resort to this mutilating surgery and the clinicopathological variables in that context. The study was done at a cancer centre in Northeast India. It was an ambispective study design, where the patient cohort who underwent FQA was identified retrospectively from the operative register of major surgeries for the time period 1st June 2020 to 31st May 2022 (24 months), and these patient...
Source: Indian Journal of Surgical Oncology - July 15, 2023 Category: Cancer & Oncology Source Type: research
The novel dynamic nomogram and risk classification system constructed for predicting post-surgical overall survival and mortality risk in primary chondrosarcoma: a population study based on SEER database
ConclusionWe successfully constructed and validated the first nomogram that could reliably predict 3-, 5-, and 8-year post-surgical OS in primary chondrosarcoma patients. Furthermore, the web-based dynamic nomogram could be more conveniently applied to clinic, providing assistance to surgeons and patients. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - July 15, 2023 Category: Cancer & Oncology Source Type: research
Establishment and characterization of a novel dedifferentiated chondrosarcoma cell line, SMU-DDCS, harboring an IDH1 mutation
AbstractDedifferentiated chondrosarcoma (DDCS) is a high-grade subtype with a bi-morphic histological appearance of a conventional chondrosarcoma component and it can abruptly transition to a high-grade non-cartilaginous sarcoma. To better understand the biological features of DDCSs and to help develop new therapies, a novel DDCS cell line, SMU-DDCS, was established. Tissue from an open biopsy of a tumor resected from a 75-year-old patient was subjected to primary culture. The cell line was established and authenticated by assessing DNA microsatellite short tandem repeats. The cells maintained in monolayer cultures exhibit...
Source: Human Cell - July 15, 2023 Category: Cytology Source Type: research
Cancers, Vol. 15, Pages 3603: IDH Mutations in Chondrosarcoma: Case Closed or Not?
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Chondrosarcomas are malignant cartilage-producing tumours that frequently harbour isocitrate dehydrogenase 1 and -2 (IDH) gene mutations. Several studies have confirmed that these mutations are key players in the early stages of cartilage tumour development, but their role in later stages remains ambiguous. The prognostic value of IDH mutations remains unclear and preclinical studies have not identified effective treatment modalities (in)directly targeting these mutations. In contrast, the IDH mutation status is a prognostic factor in other cancers, and IDH mutant inhibitors as well as therapeutic strategies targeti...
Source: Cancers - July 13, 2023 Category: Cancer & Oncology Authors: Sanne Venneker Judith V. M. G. Bov ée Tags: Review Source Type: research
