Psychedelic Science 2023 – Film Festival Day
I love how friendly and open the vibe is here at Psychedelic Science 2023 in Denver.
As we were heading down the elevator in our hotel yesterday, we got to chatting with an enthusiastic attendee on the way out. She told us they had to cap registrations at 11,500 and turn away 70 interested vendors. That doesn’t surprise me. We’re clearly in a wave of surging interest in psychedelics. I’m here because I’m keenly interested to learn more about the potential for using psychedelics for self-development. I’ve only done a few psychedelic journeys so far, and I’d say there’s a 99% chan...
Source: Steve Pavlina's Personal Development Blog - June 21, 2023 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Creating Reality Lifestyle Source Type: blogs
Senolytic Drug Discovery as a Proving Ground for New Machine Learning Approaches
In principle, machine learning can be used to make small molecule drug discovery run more rapidly, more cost-effectively, and with a greater chance of success. The development of senolytic drugs to clear senescent cells is a good proving ground for this type of approach, and will likely accelerate investment into machine learning driven drug discovery platforms with broad application. Firstly, the state of the science shows that senescent cells are vulnerable to mechanisms that can be targeted effectively by small molecules. Secondly, it is also clear that far from all of these mechanisms are known and much remains to be d...
Source: Fight Aging! - June 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Can You Drink Coconut Water With Hypertension?
Conclusion
So, circling back to our initial question: Can you drink coconut water if you have hypertension?
The evidence seems to suggest that the answer is yes, provided it’s consumed in moderation, given its potassium and magnesium content.
However, one must not overlook potential risks associated with overconsumption.
A cornerstone of any dietary change, especially concerning a health condition like hypertension, is professional healthcare advice.
Always consult your healthcare provider before making significant changes to your diet.
After all, managing hypertension is an individual journey,...
Source: The EMT Spot - June 18, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
poem
Taylor SwiftAt the Taylor Swift show in PittsburghMost of the restrooms were reserved femaleWhen I finally found a men ’s roomIt was near empty and very cleanAs I pissed a pleasant tropical fragrance Wafted around me in heady swirls.It struck me the pains we take to mitigateThe foul, the ugly, the reeking, the distastefulMy own piss, via complex chemical reactionsWith the lime green slab at the baseWas creating a Costa Rican faunaOf sweet citrusy florality It ’s just piss, I thoughtIt ’s just me and my own pissI didn ’t need this Funeral home perfumes, deodorants and antiperspirantsThe way we d...
Source: Buckeye Surgeon - June 18, 2023 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Physical and Cognitive Impairments
My symptoms get much worse after brain surgery. (Source: Depth-First)
Source: Depth-First - June 17, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Of moths and box
This is a female Box-tree Moth. They were inadvertently brought into the UK in 2007 on imported, exotic Box plants. They are spreading rapidly and I see lots in Cottenham. I don’t think they’ve got as far north as Ely yet, but it’s only a matter of time.
Female Box-tree Moths lack the male’s hair pencil at the end of the abdomen
The female lays her eggs on Box plants and her larvae will ravage the plant, you’ll see the damage pretty quickly. In their native environment the moths are kept in check somewhat by the ecosystem itself, but that doesn’t happen here. I have warned people not to ...
Source: David Bradley Sciencebase - Songs, Snaps, Science - June 16, 2023 Category: Science Authors: David Bradley Tags: Lepidoptera Source Type: blogs
Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri.
A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards Small Molecules that Induce Expression of Reprogramming Factor OCT4
Reprogramming involves inducing expression of reprogramming factors, canonically OSKM (OCT4, SOX2, KLF4, and MYC), the Yamanaka factors. When expressed for a sufficiently long time, a period of days to weeks, some fraction of OSKM-expressing cells dedifferentiate into induced pluripotent stem cells (iPSCs). Before that happens, however, beneficial epigenetic changes occur, resetting a cell to a more youthful pattern of gene expression, resulting in improvements such as restored mitophagy and mitochondrial function. The present focus of the industry is to find a way to safely apply transient exposure to reprogramming factor...
Source: Fight Aging! - June 7, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The G-Word
I finally get a name for my attacker. (Source: Depth-First)
Source: Depth-First - June 7, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Urine Test for Parkinson ’s Disease
Scientists at Purdue University have developed a urine test for early-stage Parkinson’s disease. The technology involves isolating extracellular vesicles of neural origin from urine samples and then assessing the proteins within the vesicles to detect biomarkers of the disease. The researchers have called their technology “EVtrap” (Extracellular Vesicles total recovery and purification) and it involves using magnetic beads to concentrate extracellular vesicles in urine, before subsequent proteomics analysis. The goal of the technique is to detect levels of LRRK2 (leucine-rich repeat kinase 2) proteins and related dow...
Source: Medgadget - June 6, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Neurology parkinson's purdue Source Type: blogs
An Example of In Silico Drug Screening for Senolytic Compounds
The average small molecule drug development program starts with a mechanism, an intended outcome such as inhibition, and then screening of as many molecules as possible from the libraries. Sometimes it is possible to make educated guesses as to what types of molecule are more likely to be useful, but often screening must be very broad and with little direction. In principle, low cost computation makes it possible to dramatically reduce the cost of discovery of useful molecules given a specific target mechanism. This shift from physical to in silico screening has been underway for a while, for example at Insilico Medicine, ...
Source: Fight Aging! - June 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Reflections on My Brain Surgery
One nerd ' s attempt to cope with an overwhelming situation. (Source: Depth-First)
Source: Depth-First - June 2, 2023 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Pencil-on-Paper Wearable Sensor
Researchers at Penn State have developed a low-cost, wearable sensor using pencil-on-paper technology. This approach involves depositing graphite (pencil ‘lead’) on paper that has been treated with sodium chloride, to create a conductive, low-cost sensor. Previously, these researchers had developed such sensors to detect moisture and even used them to develop a smart diaper (yes, really). However, they have now developed a hydrophobic version of the sensor that is not affected by water to create a skin-worn device that can measure a variety of health data, including assessments of gas molecules, temperature, and electr...
Source: Medgadget - June 1, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiology Diagnostics Materials PennState Source Type: blogs
Smart Sutures Sense Inflammation, Deliver Drugs, Cells
Researchers at MIT have developed smart sutures with a hydrogel coating that contains sensing and drug delivery components, and could even be used to implant therapeutic cells. The sutures are made using pig tissues that have been decellularized with detergents to reduce the possibility that they could provoke an immune reaction. The surrounding hydrogel layer contains microparticles that can release peptides when enzymes involved in inflammation are present, and other microparticles that allow for controlled release of drugs. Another potential cargo is therapeutic stem cells that can assist with tissue repair. So far, the...
Source: Medgadget - May 30, 2023 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Medicine Surgery mit sutures Source Type: blogs
