Reviewing the Path Towards Reprogramming as a Basis for Rejuvenation Therapies
In conclusion, while partial reprogramming holds great therapeutic potential, the real focus should be on rejuvenation research, defining its nature and ways to quantify it. Another critical issue is the ability to quantify biological age as reprogrammed older cells acquire younger states. Understanding rejuvenation is also key to translational success, as benefits of age reversal must be considered against risks. More research into safety and tissue-specific responses of this technique are required. (Source: Fight Aging!)
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Science Snippet: Examining Enzymes
Structure of a pyruvate kinase, an enzyme that adds a phosphate group to adenosine diphosphate (ADP) to make adenosine triphosphate (ATP). Credit: PDB 7UEH. Every day, our cells must produce all the various molecules they need to stay alive. But the chemical reactions to create these molecules can’t occur without help—which is where enzymes come in. Enzymes are biological catalysts, meaning they speed up the rate of specific chemical reactions by reducing the amount of energy needed for the reaction to occur. Most enzymes are proteins, but some RNA molecules can also act as enzymes. Thousands of different enzymes ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 13, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes Proteins Science Snippet Source Type: blogs

An Example of Antihypertensive Drug Discovery Based on TRPV2 Biochemistry
This study represents a very important starting point for using this TRPV2 activation as a therapeutic strategy against diseases that cause excessive vasoconstriction, such as hypertension." In a second study, the research group used computational techniques to identify a set of 270 molecules that, due to their physical and chemical characteristics, could interact with TRPV2, and grouped them by families according to how each of these molecules would bind to TRPV2. Then, by expressing the TRPV2 protein in yeast, a screening system was designed to test its effects. This made it possible to find a molecule (4-piperid...
Source: Fight Aging! - March 13, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

My Struggle for a Good Death
Choosing from a wide selection of bad options. (Source: Depth-First)
Source: Depth-First - March 11, 2024 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process. « Back to Top Considering the Mechanisms of Vascular Calcification https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/ Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Catalase to Reduce Mitochondrial Oxidative Stress Does Not Reduce Cellular Senescence
Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now integrated into the cell. Mitochondria generate oxidative molecules as a consequence of the processes that generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. Those oxidative molecules cause damage, near all rapidly repaired. They also serve as signals, such as in the beneficial response to exercise. With aging, however, mitochondrial function becomes impaired and the degree of oxidative stress generated by the operation of mitochondria becomes harmful. Researchers have in the...
Source: Fight Aging! - March 5, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Amie Fornah Sankoh Achieves a Scientific Dream
Credit: LinkedIn. “I wanted to give up so many times. Although I tried to remain positive, I never thought I’d be able to finish my Ph.D. But I made it, and I’m extremely proud of myself,” says Amie Fornah Sankoh, Ph.D., a research scientist with Dow Chemical Company who received NIGMS support as a graduate student. Human and Plant Communication Dr. Sankoh has loved science and mathematics since she was just a child growing up in Sierra Leone. When she was 3 years old, Dr. Sankoh became deaf from a childhood disease. Math, unlike other subjects, is very visual, which played a part in her interest in it. “...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 28, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Training Source Type: blogs

Developing Low-Cost Lab Techniques: Q & A With Abraham Badu-Tawiah
Credit: Ohio State University. “I never thought I could make an impact on chemistry and students’ lives. But now, I’m the head of a lab with several Ph.D. and undergraduate students and a postdoctoral researcher; and we’re developing simple, low-cost lab techniques that can be adopted by labs across the world,” says Abraham Badu-Tawiah, Ph.D., the Robert K. Fox Professor of Chemistry at Ohio State University in Columbus. We talked with Dr. Badu-Tawiah about his career progression, research, and advice for students hoping to launch a career in science. Q: How did you get started on the path to a career in sci...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 21, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Profiles Source Type: blogs

The Witness
Just because it ' s legal doesn ' t make it right. (Source: Depth-First)
Source: Depth-First - February 20, 2024 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

More epistemology
Many people find it uncomfortable to live with deep mystery. They want their questions answered. Many people also need to be handed meaning and purpose on a platter -- it ' s too difficult to make their own, especially in the face of hardship and injustice. Making up stories that seem to satisfy the need for explanation and meaning is a temptation that many just can ' t resist. But for other people, testing stories against empirical reality is more important. Whatever dissatisfaction or psychological distress we suffer from choosing to live in reality is worth it to us, because we want the truth more than anything. On...
Source: Stayin' Alive - February 17, 2024 Category: American Health Source Type: blogs

The 2024 Word of the Year: Missense
By MIKE MAGEE Not surprisingly, my nominee for “word of the year” involves AI, and specifically “the language of human biology.” As Eliezer Yudkowski, the founder of the Machine Intelligence Research Institute and coiner of the term “friendly AI” stated in Forbes: “Anything that could give rise to smarter-than-human intelligence—in the form of Artificial Intelligence, brain-computer interfaces, or neuroscience-based human intelligence enhancement – wins hands down beyond contest as doing the most to change the world. Nothing else is even in the same league.”  Perhaps the ...
Source: The Health Care Blog - February 13, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biology Crispr DNA Mike Magee Source Type: blogs

What Does an Immunologist Do?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed. Immunology is the study of the immune system, including all the cells, tissues, and organs that work together to protect you from germs. A person who studies immunology is called an immunologist, and there are three types: Researchers, who study the immune system in the laboratory to understand how it works or how it can go awry and find new treatments for immune system-related diseases Doctors, who diagnose and care for patients with diseases related to the immune system, such as ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 12, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Injury and Illness Immunology Miniseries Infectious Diseases Medicines Microbes Research Roundup Source Type: blogs

Fight Aging! Newsletter, February 12th 2024
In conclusion, frailty is a dynamic process, and improved frailty and remaining robust are significantly associated with lower risk of all-cause mortality and cardiovascular death in older people. « Back to Top Greater Individual Wealth Correlates with Longer Life Expectancy https://www.fightaging.org/archives/2024/02/greater-individual-wealth-correlates-with-longer-life-expectancy/ Individual wealth correlates with life expectancy, with an effect size that is in the same ballpark as those related to lifestyle choices involving exercise, diet, and consequences thereof. It remains unclear...
Source: Fight Aging! - February 11, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The bias of reality
Stephen Colbert -- or rather " Stephen Colbert, " in his former character -- famously said that " Reality has a well-known liberal bias. " And so conservatives must deny reality, which as in the case of anthropogenic climate change means denying scientific findings, and the very integrity and authority of science. But that doesn ' t usually work very well with the courts --viz. the jury award of $1 million to climate scientist Michael Mann -- so they also result to scientific fraud.You may recall that U.S. District Judge Matthew Kacsmaryk ruled to suspend FDA approval of the abortion medication mifepristone,relying largely...
Source: Stayin' Alive - February 9, 2024 Category: American Health Source Type: blogs

A Mitochondrial View of Muscle Aging
The hundreds of mitochondria present in every cell are primarily responsible for generating adenosine triphosphate, a chemical energy store molecule used to power cell operations. Mitochondria are the descendants of ancient symbiotic bacteria, and carry a small circular genome, the mitochondrial DNA. They replicate as needed, can fuse together and swap component parts, and damaged mitochondria are removed by cell maintenance processes. Mitochondrial function declines with age for a variety of reasons that include damage to mitochondrial DNA and changes in the expression of genes involved in replication, fusion, and quality...
Source: Fight Aging! - February 7, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs