Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology. « Back to Top Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins. Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Mitochondrial Dysfunction in the Aging of the Brain
Mitochondria are the power plants of the cell, primarily responsible for packaging adenosine triphosphate (ATP) molecules as chemical energy stores for use throughout the cell. Hundreds of mitochondria swarm inside every cell, the descendants of ancient symbiotic bacteria. These organelles retain many features characteristic of bacteria. For example, mitochondria contain a small circular genome, depleted of genes that have moved into the cell nucleus over evolutionary time. Mitochondria also constantly divide, fuse together, and swap component parts. Mitochondrial quality is controlled by the processes of mitophagy that re...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Reviewing the Path Towards Reprogramming as a Basis for Rejuvenation Therapies
In conclusion, while partial reprogramming holds great therapeutic potential, the real focus should be on rejuvenation research, defining its nature and ways to quantify it. Another critical issue is the ability to quantify biological age as reprogrammed older cells acquire younger states. Understanding rejuvenation is also key to translational success, as benefits of age reversal must be considered against risks. More research into safety and tissue-specific responses of this technique are required. (Source: Fight Aging!)
Source: Fight Aging! - March 14, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Science Snippet: Examining Enzymes
Structure of a pyruvate kinase, an enzyme that adds a phosphate group to adenosine diphosphate (ADP) to make adenosine triphosphate (ATP). Credit: PDB 7UEH. Every day, our cells must produce all the various molecules they need to stay alive. But the chemical reactions to create these molecules can’t occur without help—which is where enzymes come in. Enzymes are biological catalysts, meaning they speed up the rate of specific chemical reactions by reducing the amount of energy needed for the reaction to occur. Most enzymes are proteins, but some RNA molecules can also act as enzymes. Thousands of different enzymes ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 13, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Cellular Processes Proteins Science Snippet Source Type: blogs

An Example of Antihypertensive Drug Discovery Based on TRPV2 Biochemistry
This study represents a very important starting point for using this TRPV2 activation as a therapeutic strategy against diseases that cause excessive vasoconstriction, such as hypertension." In a second study, the research group used computational techniques to identify a set of 270 molecules that, due to their physical and chemical characteristics, could interact with TRPV2, and grouped them by families according to how each of these molecules would bind to TRPV2. Then, by expressing the TRPV2 protein in yeast, a screening system was designed to test its effects. This made it possible to find a molecule (4-piperid...
Source: Fight Aging! - March 13, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

My Struggle for a Good Death
Choosing from a wide selection of bad options. (Source: Depth-First)
Source: Depth-First - March 11, 2024 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process. « Back to Top Considering the Mechanisms of Vascular Calcification https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/ Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Catalase to Reduce Mitochondrial Oxidative Stress Does Not Reduce Cellular Senescence
Every cell contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now integrated into the cell. Mitochondria generate oxidative molecules as a consequence of the processes that generate the chemical energy store molecule adenosine triphosphate (ATP), used to power the cell. Those oxidative molecules cause damage, near all rapidly repaired. They also serve as signals, such as in the beneficial response to exercise. With aging, however, mitochondrial function becomes impaired and the degree of oxidative stress generated by the operation of mitochondria becomes harmful. Researchers have in the...
Source: Fight Aging! - March 5, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Amie Fornah Sankoh Achieves a Scientific Dream
Credit: LinkedIn. “I wanted to give up so many times. Although I tried to remain positive, I never thought I’d be able to finish my Ph.D. But I made it, and I’m extremely proud of myself,” says Amie Fornah Sankoh, Ph.D., a research scientist with Dow Chemical Company who received NIGMS support as a graduate student. Human and Plant Communication Dr. Sankoh has loved science and mathematics since she was just a child growing up in Sierra Leone. When she was 3 years old, Dr. Sankoh became deaf from a childhood disease. Math, unlike other subjects, is very visual, which played a part in her interest in it. “...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 28, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Profiles Training Source Type: blogs

Developing Low-Cost Lab Techniques: Q & A With Abraham Badu-Tawiah
Credit: Ohio State University. “I never thought I could make an impact on chemistry and students’ lives. But now, I’m the head of a lab with several Ph.D. and undergraduate students and a postdoctoral researcher; and we’re developing simple, low-cost lab techniques that can be adopted by labs across the world,” says Abraham Badu-Tawiah, Ph.D., the Robert K. Fox Professor of Chemistry at Ohio State University in Columbus. We talked with Dr. Badu-Tawiah about his career progression, research, and advice for students hoping to launch a career in science. Q: How did you get started on the path to a career in sci...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - February 21, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques Profiles Source Type: blogs

The Witness
Just because it ' s legal doesn ' t make it right. (Source: Depth-First)
Source: Depth-First - February 20, 2024 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs

More epistemology
Many people find it uncomfortable to live with deep mystery. They want their questions answered. Many people also need to be handed meaning and purpose on a platter -- it ' s too difficult to make their own, especially in the face of hardship and injustice. Making up stories that seem to satisfy the need for explanation and meaning is a temptation that many just can ' t resist. But for other people, testing stories against empirical reality is more important. Whatever dissatisfaction or psychological distress we suffer from choosing to live in reality is worth it to us, because we want the truth more than anything. On...
Source: Stayin' Alive - February 17, 2024 Category: American Health Source Type: blogs

The 2024 Word of the Year: Missense
By MIKE MAGEE Not surprisingly, my nominee for “word of the year” involves AI, and specifically “the language of human biology.” As Eliezer Yudkowski, the founder of the Machine Intelligence Research Institute and coiner of the term “friendly AI” stated in Forbes: “Anything that could give rise to smarter-than-human intelligence—in the form of Artificial Intelligence, brain-computer interfaces, or neuroscience-based human intelligence enhancement – wins hands down beyond contest as doing the most to change the world. Nothing else is even in the same league.”  Perhaps the ...
Source: The Health Care Blog - February 13, 2024 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biology Crispr DNA Mike Magee Source Type: blogs