Wolf spider (Schizocosa ocreata)
A wolf spider ( Schizocosa ocreata). Researchers discovered that wolf spiders can't communicate with potential mates as easily on wet leaves, relying more on visual signals rather than chemical or vibratory cues after it rains.
[Research supported by U.S. National Science Foundation ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - February 3, 2024 Category: Science Source Type: video
Computation model predicts transition states of reactions
During a chemical reaction, molecules gain energy until they reach what’s known as the transition state — a point of no return from which the reaction must proceed. Using generative AI, researchers created a computation model that can rapidly calculate and predict the transition state of a reaction ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - January 12, 2024 Category: Science Source Type: video
Designing Nanoparticles to Probe and Cross Biological Barriers to Immunotherapy
The Mucosal Associated Immune System Engineering and Lymphatics (MAISEL) Lab ’ s research integrates nanotechnology, materials science, and tissue engineering with physiology, medicine, and immunology to probe lymphatics and extracellular barriers via novel ex vivo and in vitro models and nanoparticles. We are particularly focused on studying mucosal barriers to the therapeutic path from the mucosal lumen to the downstream lymph nodes and integrating the newly created knowledge to design immune modulatory therapeutic interventions. We have made significant progress in understanding how nanoparticle material properties li...
Source: Videocast - All Events - November 14, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The Future of CRISPR: What ’ s Ahead for Genome Editing
Jennifer Doudna is a Nobel Laureate in Chemistry, and a Professor of Biochemistry, Biophysics and Structural Biology. Her research focuses on RNA as it forms a variety of complex globular structures, some of which function like enzymes or form functional complexes with proteins. Her lab's research into RNA biology led to the discovery of CRISPR-Cas9 as a tool for making targeted changes to the genome. In bacteria, CRISPR systems preserve invading genetic material and incorporate it into surveillance complexes to achieve adaptive immunity. Crystal structures of diverse Cas9 proteins reveal RNA-mediated conformational activa...
Source: Videocast - All Events - August 30, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Generative Biology: Learning to Program Cellular Machines
My general scientific interests are in understanding how genetically encoded molecular programs can yield the remarkable behaviors observed in biological organisms, at multiple scales. I began my research career as a biophysical chemist and structural biologist studying problems such as the evolutionary optimization of enzymes, how protein structure is encoded in sequence, and the determinants of protein-protein interaction specificity. My research has gradually shifted towards utilizing this mechanistic understanding of molecules as a foundation to study how systems of interacting molecules assemble to yield cellular or o...
Source: Videocast - All Events - August 22, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
The dark side of DNA - how the immune system senses DNA as a danger signal
Zhijian “ James ” Chen ’ s research into complex cellular biochemistry has led to the discovery of pathways and proteins that trigger immune and stress responses. Chen has identified proteins, such as the mitochondrial protein MAVS, that are crucial to the body ’ s defense against RNA viruses such as influenza and Ebola. Now, Chen and his team are dissecting a signaling pathway involving a novel DNA sensor – cyclic GMP-AMP (cGAMP) synthase, or cGAS – which activates an interferon response that may play a role in immune defense against pathogens and malignant cells, as well as in autoimmune diseases such as lupu...
Source: Videocast - All Events - July 26, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Bioorthogonal chemistry, the journey from basic science to clinical translation
Part of the Wednesday Afternoon Lecture Series, the lecture is given by a researcher dedicated to advancing and improving the careers of women scientists. Since 1994 when this annual lecture began, every speaker has exemplified the intelligence, scientific excellence and drive that made Margaret Pittman a leader as the first female laboratory chief at NIH.
Professor Carolyn Bertozzi's research interests span the disciplines of chemistry and biology with an emphasis on studies of cell surface sugars important to human health and disease. Her research group profiles changes in cell surface glycosylation associated with ca...
Source: Videocast - All Events - July 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
2023 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture
Special CCR Grand Rounds 2023 AAAS Martin and Rose Wachtel Cancer Research Award and Lecture “ Harnessing Microenvironmental Dependencies for Cancer Therapy – The Role of the Nervous System in Cancer Growth ” Humsa Venkatesh, Ph.D.Assistant Professor of Neurology Brigham and Women's Hospital Harvard Medical SchoolFriday, July 28, 202312:00 – 1:15 p.m.Lipsett AmphitheaterAlso available to view via NIH Videocast.To register for the lecture, please visit https://go.cancer.gov/BsJHlb0 The Wachtel Cancer Research Award is presented to early-career scientists who have made outstanding contributions to the field of cancer...
Source: Videocast - All Events - July 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
2023 Safety, Health and Wellness Day
National Institutes of Health (NIH) Safety, Health and Wellness Day will be held on Thursday, June 29, from 10:00am – 2:00pm, on the South lawn and patio area of Building 10, NIH Bethesda campus. Everyone is welcome to come and enjoy the activities and learn about safety, health, and wellness opportunities at NIH. This year's event – held in person for the first time since 2019 – will focus on enhancing employee awareness of mental health, wellness, chemical safety, roadway and pedestrian safety, and preventing/reducing work-related injuries and illnesses.For more information go tohttps://ors.od.nih.gov/sr/dohs/Event...
Source: Videocast - All Events - June 7, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Biomedical Engineering Scientific Interest Group: Engineering mucus and innate lung defense
Gregg Duncan earned his Ph.D. in chemical engineering under the guidance of Michael Bevan at Johns Hopkins University in 2014. He then completed his postdoctoral training at Johns Hopkins School of Medicine in the Center for Nanomedicine directed by Justin Hanes. Dr. Duncan is currently an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland. Dr. Duncan leads the Respiratory Nano Bioengineering (RnB) lab, which aims to understand the airway microenvironment in health and disease to engineer new therapeutic strategies for obstructive lung diseases such as asthma, chronic obstructive...
Source: Videocast - All Events - May 23, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Ozone hole over the South Pole on Oct. 5, 2022
A map showing the size and shape of the ozone hole over the South Pole on Oct. 5, 2022. A study found that smoke particles in the stratosphere can trigger chemical reactions that erode the ozone layer and that smoke particles from Australian wildfires widened the ozone hole by 10% in 2020. ...This is an NSF Multimedia Gallery item. (Source: NSF Multimedia Gallery)
Source: NSF Multimedia Gallery - May 20, 2023 Category: Science Source Type: video
Author Lecture and Meet-and-Greet with Nick Lane - Transformer: The Deep Chemistry of Life and Death
Please join us for a special lecture and reception with scientist and author Nick Lane, Ph.D., a British biochemist and writer. He is a professor in evolutionary biochemistry at University College London. He has published five books to date which have won several awards. His latest book, and the subject of this lecture, is Transformer: The Deep Chemistry of Life and Death. This lecture is sponsored mutually by FAES, the OIR, and Demystifying Medicine.Air date: 6/26/2023 2:00:00 PM (Source: Videocast - All Events)
Source: Videocast - All Events - May 19, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
NIH Director's Seminar Series: How the fat gets on proteins – structure and mechanism of enzymes that catalyze protein palmitoylation
Posttranslational modification of proteins by attachment of lipids touches almost all areas of cellular physiology. One of the major areas of interest in our lab are integral membrane enzymes that catalyze protein lipidation. The most widely prevalent form of protein lipidation is protein S-acylation or protein palmitoylation whereby membrane proximal cysteines are modified by fatty acids through a thioester linkage. Protein palmitoylation, owing to its inherent lability through the action of cellular thioesterases, offers a unique, potentially dynamic form of protein lipidation. There are 23 members of the DHHC family of ...
Source: Videocast - All Events - May 8, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
Expanding Translationally Relevant Chemical Space: Insights Into Natural Product Resources, Technologies, and Mechanisms (Part-Two) — April 28, 2023
This two-part Hot Topic Webinar Series highlights emerging trends in natural products research. Experts in the natural products field will touch on topics in organic structure analysis, metabologenomics, venomics, high-throughput phenotypic screening, electron microscopy techniques, host microbe interactions, and structural biology. In Part Two of the series will take place on April 28, 2023. This webinar will focus on applications of emerging research technologies to elucidate the mechanism of action of bioactive natural products. Part One took place on March 6, 2023, and covered natural product research resources enablin...
Source: Videocast - All Events - April 27, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
BME-SIG Lecture with Molly Schoichet
Drug discovery in cancer typically involves screening cells grown on 2-dimensional, hard plastic dishes; however, since human tissue is neither 2D nor plastic, this environment does not sufficiently emulate human disease. To overcome this limitation, we designed materials (i.e., hydrogels) for 3-dimensional cell culture with the goal of screening cells in an environment that mimics that of native tissue. With 3D cell culture, we gain an understanding of both cell invasion and cell viability, thereby providing insights that are inherently limited with traditional 2D cell culture. To achieve a suitable environment, we synthe...
Source: Videocast - All Events - April 24, 2023 Category: General Medicine Tags: Upcoming Events Source Type: video
