Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Epigenetic Clock Data from the CALERIE Trial of Calorie Restriction
The practice of calorie restriction extends life notably in short-lived mammals, but not in long-lived mammals, despite the short-term benefits to health appearing quite similar in mice and humans. This may be because many of the beneficial shifts in metabolism triggered by a low calorie intake are already built in to long-lived species, as a part of the history of evolutionary change that led to those species becoming long-lived. Since calorie restriction alters near every aspect of cellular biochemistry, coming up with a comprehensive understanding of the important mechanisms has been a slow process, never mind how those...
Source: Fight Aging! - February 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

TL:DR – Too long, didn ’ t read
TL:DR – Adding article summaries to my blog posts to help readers better navigate the 3700 Sciencebase posts. Back in the days of print journalism, we used to write our copy, attach a headline and perhaps a strapline. For a news story, the article would usually follow a kind of pyramid structure. The headline telling pretty much the whole story, the strapline expanding on it a little, then the article building on the conventional Who, Why, What, Where, and When etc. Of course, once editors got their hands on it, your sacred text might be shredded and at the very least the headline and strapline would be stripped awa...
Source: David Bradley Sciencebase - Songs, Snaps, Science - February 15, 2023 Category: Science Authors: David Bradley Tags: Sciencebase Stuff Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

TikTok and the “New News” Media
Paul MatzkoTake a  second and think about how you heard about the recent train derailment in Ohio, which created a giant cloud of toxic chemicals and forced a mass evacuation. It’s the plot ofWhite Noise come to life.If you ’re reading this, then odds are you first heard about the crash online. But if you’re one of the dwindling number of people who rely on local newspapers and tv station for news, then you’ll likely have seen stories that mostly just repeat official statements from the authorities.“If you are in this red zone that is on the map, and you refuse to evacuate, you are risking death,”said PA Go...
Source: Cato-at-liberty - February 10, 2023 Category: American Health Authors: Paul Matzko Source Type: blogs