Pharmaceutical profiteering
Another reason why we spend more on pharmaceuticals than the rest of the world ( " drugs " also means fentanyl and crank so I ' m trying to disambiguate here) is the profit motive. There are perverse incentives built into the system that encourage use of higher priced chemicals when cheaper ones would be as good or better for patients.There are some medications that people can ' t take at home. You have to go to a physician ' s office and have them infused. Medicare pays the physician a percentage of the cost of the drug, which means, obviously, that doctors make more money infusing a $10,000 drug than they would infusing ...
Source: Stayin' Alive - January 20, 2024 Category: American Health Source Type: blogs
Fight Aging! Newsletter, January 15th 2024
In conclusion, FMD cycles have high potential to be effective in increasing the toxicity of a range of therapies against ALL and other blood cancers and should be tested in randomized clinical trials, especially in combination with immunotherapy and low toxicity cancer therapies.
In summary, we present a new strategy for improving leukemia treatment by combining FMD with chemotherapy to promote the killing of ALL cells in part by an immune-dependent mechanism. Fasting/FMD has been shown to reduce chemotherapy-associated toxicity in pre-clinical and clinical studies and thus represents a safe and potentially effectiv...
Source: Fight Aging! - January 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Wanted: Chemistry and Chemical Biology Program Director
We’re seeking a highly qualified scientist to serve as a program director in our Division of Pharmacology, Physiology, and Biological Chemistry (PPBC). This is a newly created position for the Division as it reorganizes into three Branches. Applicants should have significant interest and experience in the scientific areas comprising the newly formed Chemistry and Chemical Biology Branch. The purpose of the Branch is to foster meritorious research in chemical biology, synthetic biology, chemical catalysis and synthesis, carbohydrate chemistry, natural products, bioinorganic chemistry, and metabolic engineering. We seek...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - January 10, 2024 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Job Announcements Source Type: blogs
RISE-ing Stars From Northern Arizona University
Chantel Tsosie at her college graduation, wearing her Tribe’s formal, traditional rug dress that her grandmother made. Credit: Courtesy of Chantel Tsosie.
“Science is for everyone. It’s in everything. It exists in cultures everywhere,” says Chantel Tsosie, a master’s student in the NIGMS-supported Research Initiative for Scientific Enhancement (RISE) program at Northern Arizona University (NAU) in Flagstaff. The program aims to prepare a diverse group of students for research careers through culturally relevant support, hands-on research experiences, and a tailored curriculum.
Chantel started her bachelor’...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 10, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Training Source Type: blogs
Visualizing Clearance of Cerebrospinal Fluid via the Glymphatic System
In this study, we describe an MRI method based on chemical exchange saturation transfer (CEST) of the Angiopep-2 probe to visualize the clearance function of the glymphatic system.
We injected rats with Angiopep-2 via the tail vein and performed in vivo MRI at 7 T to track differences in Angiopep-2 signal changes; we then applied the same principles in a bilateral deep cervical lymph node ligation rat model and in ageing rats. We demonstrated the feasibility of Angiopep-2 CEST for visualizing the clearance function of the glymphatic system. Finally, a pathological assessment was performed. Within the model group, th...
Source: Fight Aging! - January 9, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
DCA and Me
The proof of the pudding is in the eating. (Source: Depth-First)
Source: Depth-First - January 8, 2024 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Fight Aging! Newsletter, January 8th 2024
This study examined whether the local injection of the supernatant of activated PRP (saPRP) into the salivary gland (SG) could help prevent aging-induced SG dysfunction and explored the mechanisms responsible for the protective effects on the SG hypofunction.
Human salivary gland epithelial cells (hSGEC) were treated with saPRP or PRP after senescence through irradiation. The significant proliferation of hSGEC was observed in saPRP treated group compared to irradiation only group and irradiation + PRP group. Cellular senescence, apoptosis, and inflammation were significantly reduced in the saPRP group.
Th...
Source: Fight Aging! - January 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Crystal Gardens
A chance encounter leads to a new life. (Source: Depth-First)
Source: Depth-First - January 5, 2024 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Inspiring the Next Generation of Scientists Through CityLab
Credit: CityLab.
“Many of the students we work with don’t have access to a laboratory through their local schools. For them, CityLab is their first exposure to a laboratory environment—these are hugely important moments for these kids,” says Carl Franzblau, Ph.D., the founder of CityLab at Boston University (BU). CityLab was established more than 30 years ago as a science education outreach program for precollege students and teachers through a partnership between the Chobanian & Avedisian School of Medicine and the Wheelock College of Education & Human Development at BU.
“Since our first Science Edu...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 3, 2024 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology STEM Education SEPA Training Source Type: blogs
Failing Mitochondrial Quality Control in Aging and Neurodegeneration
Every one of our cells contains hundreds of mitochondria, the descendants of ancient symbiotic bacteria now fully integrated into our biochemistry. Mitochondria contain their own small remnant genome, the mitochondrial DNA, replicate like bacteria, and toil to produce adenosine triphosphate (ATP), a chemical energy store molecule used to power cell processes. Mitochondrial function declines with age, unfortunately, and our cells suffer for it. This contributes meaningfully to many age-related conditions. This decline appears to result in large part from changes in gene expression that impair the various quality control pro...
Source: Fight Aging! - January 2, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
My battle with atrial fibrillation
A while ago, I wrote about my experience during an attack of atrial fibrillation (afib), lamenting the fact that my management never included a proper physical exam. Nevertheless, chemical cardioversion was successful, and my hospital stay was brief. The episode was precipitated by a small pulmonary embolus acquired during sinus surgery the day before. I
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My battle with atrial fibrillation originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 31, 2023 Category: General Medicine Authors: Martin C. Young, MD Tags: Conditions Cardiology Source Type: blogs
Ring In the New Year With Basic Research
Empowering basic biomedical research, which focuses on understanding how living systems work, is one of NIGMS’ main goals. This type of research not only helps us learn how our bodies and those of other organisms function but also lays the foundation for advances in disease diagnosis, treatment, and prevention.
We’re excited to see what the upcoming year has in store for the field! In preparation, we’re highlighting what NIGMS-supported scientists had to say in 2023 about the many merits of basic research. Also check out the links to the Biomedical Beat posts that feature them if you haven’t already.
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Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 27, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Scientific Process Source Type: blogs
The surprising science of gratitude: How it boosts your well-being
I have never been a very touchy-feely person. I was trained as a biologist and chemist, then went to medical school where more science on top of science was aimed at me like a gushing firehose. I learned to put science and evidence first and to try in my practice of medicine to use only
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The surprising science of gratitude: How it boosts your well-being originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 25, 2023 Category: General Medicine Authors: Greg Smith, MD Tags: Physician Psychiatry Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
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Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
