Implant Coating Fights Infection and Monitors Strain
Researchers at the University of Illinois at Urbana-Champaign have developed a bioinspired implant coating that is designed to be implanted along with devices such as spinal implants. The technology has been inspired by dragonfly and cicada wings that contain tiny pillars that can skewer bacteria, providing mechanical anti-microbial action. Unlike current approaches that use antibiotics that are gradually released by the implant, the mechanical approach will not become depleted over time or cause side-effects in nearby tissues. It also avoids the manifestation of antimicrobial drug resistance and can also easily kill drug-...
Source: Medgadget - May 17, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Orthopedic Surgery Source Type: blogs
Machine Learning Aids Rapid Design of Protein Therapeutics
Researchers at Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have created a machine learning approach to scan millions of protein fragments and assess their structure and binding properties. Based on the surface chemistry and geometry of a protein, the developed software can determine a ‘fingerprint’ for each protein and predict how they might bind to various protein fragments. The researchers have now used their approach to design new protein ‘binders’ that have been created specifically to bind to proteins of therapeutic interest, such as the SARS-CoV-2 spike protein. The technique could allow ...
Source: Medgadget - May 17, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine EPFL machine learning Source Type: blogs
How to Construct Measures of Biological Age
This paper provides an introduction to the several different methodological approaches that can be used to assemble a measure of biological age from data sets that exhibit changes with age. In recent years, many varied aging clocks have been produced and tested. Where such clocks are derived from epigenetic, transcriptomic, proteomic, and similar data, it remains unclear as to which processes of aging they reflect, and to what level of sensitivity. Clocks that use very few data points can produce good measures in a naturally aging population, but are unlikely to be useful when assessing the outcome of a potential rejuvenat...
Source: Fight Aging! - May 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
15 Causes Of High Blood Pressure: Your Essential Guide To Navigating Hypertension Triggers
Conclusion
In conclusion, high blood pressure can go unnoticed until it causes serious health issues, making it crucial to understand its causes and take preventative measures.
Lifestyle factors, genetics, and medical conditions can contribute to high blood pressure, but maintaining a healthy weight, exercising regularly, reducing salt intake, eating a healthy diet, limiting alcohol consumption, and quitting smoking can help prevent it.
Additionally, smart blood pressure monitors and natural supplements can aid in managing blood pressure levels and promoting heart health.
By implementing these strategies and re...
Source: The EMT Spot - May 14, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species.
We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Are The Symptoms Of High Blood Pressure?
Conclusion
To summarize, hypertension is frequently unrecognized until it becomes severe, making it one of the major reasons for death worldwide.
Unfortunately, many people are unaware of their condition and fail to recognize the symptoms. This lack of awareness can lead to serious health consequences, particularly as hypertension affects approximately 1 in 3 adults worldwide.
Although high blood pressure may not cause noticeable symptoms in many cases, some signs that may indicate a person has this condition include headaches (particularly at the back of the head), dizziness, blurred vision, shortness of breath, ...
Source: The EMT Spot - May 11, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Blood Pressure Source Type: blogs
Targeting Mitochondrial Oxidative Stress
Cells are each packed with hundreds of the organelles called mitochondria, the distant descendants of ancient symbiotic bacteria, constantly dividing, fusing, and passing around component parts. Mitochondria are the power plants of the cell, conducting energetic reactions to produce the chemical energy store molecule adenosine triphosphate. As a side-effect, these reactions produce a flux of oxidative molecules that can react with other cell components to damage them. This damage is constantly repaired in a healthy cell, and even acts as a hormetic signal under some circumstances. It is involved in the beneficial response ...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Ianap
I am not a physicist, but I do think I have a good intuitive understanding of the state of physics and cosmology today. Rather than continue this discussion in the comments to an earlier post, I thought I ' d elevate it to the front page. I would say that a funny thing happened on the way to a Theory of Everything.The profound discoveries of the 20th Century -- relativity, quantum theory, field theories and the so-called Standard Model of particles and forces, and of course Big Bang* cosmology -- to many signaled the end of metaphysics. Mere speculation about the deep nature of the universe and first causes was obsolete. T...
Source: Stayin' Alive - May 10, 2023 Category: American Health Source Type: blogs
Career Conversations: Q & A With Biochemist Prabodhika Mallikaratchy
Credit: CUNY School of Medicine.
“One of the biggest things I hope for in my career is that in 20 years, I still feel the same joy and enthusiasm for research and training that I feel now,” says Prabodhika Mallikaratchy, Ph.D., a professor in the department of molecular, cellular, and biomedical sciences at the City University of New York (CUNY) School of Medicine. Dr. Mallikaratchy talks with us about her career path, research on developing new immunotherapies and molecular tools using nucleic acids, and her belief in the importance of being passionate about your career.
Q: How did you first become interested in ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 10, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques DNA Medicines Profiles Proteins Source Type: blogs
Urine Test Could Reveal Cancer and Metastases
Researchers at MIT have developed a urine test that can distinguish between different types of cancer, and could even highlight if metastases are present. The test involves first administering nanoparticles to patients that can circulate around their blood before encountering a tumor. Enzymes that are overexpressed by the tumor can then cleave a linker on the particle surface, releasing a DNA barcode into the blood. These DNA strands are excreted in the urine, and if the patient places a urine sample on a paper strip designed by the researchers, the CRISPR/Cas system can amplify the signal to highlight its presence, which ...
Source: Medgadget - May 9, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Genetics Oncology CRISPR mit Source Type: blogs
Can You Use Blood Pressure Pills If You Are Taking Bodybuilding Supplements?
Conclusion
To summarize, natural bodybuilding supplements are a safer alternative to anabolic steroids and can help build muscle mass, increase strength, and enhance athletic performance without harmful side effects.
They can also be used safely alongside natural blood pressure supplements as long as certain precautions are taken.
It’s important to choose certified supplements and avoid bodybuilding supplements with caffeine content to prevent any adverse effects.
You can always use both in tandem provided you follow the safe and effective practices to juice the best benefits out of both.
Incorporating...
Source: The EMT Spot - May 8, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Supplements Source Type: blogs
Fight Aging! Newsletter, May 8th 2023
In conclusion, NAT mitigated age-associated cerebral injury in mice through gut-brain axis. The findings provide novel evidence for the effect of NAT on anti-aging, and highlight the potential application of NAT as an effective intervention against age-related diseases.
Retinal Cell Reprogramming Restores Vision in Non-Human Primate Study
https://www.fightaging.org/archives/2023/05/retinal-cell-reprogramming-restores-vision-in-non-human-primate-study/
Early applications of in vivo cellular reprogramming to medicine are cautiously focused on retinal regeneration. The eye is as close to an isolated system...
Source: Fight Aging! - May 7, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How To Choose The Best Supplement For Your Blood Pressure Condition?
Conclusion
To sum up, natural supplements have become popular for controlling high blood pressure due to their perceived safety compared to prescription medications, which often cause unpleasant side effects.
Prioritizing your health is essential, and seeking medical advice before taking any supplements is especially crucial, particularly if you struggle with comorbidity, pregnancy, or breastfeeding.
When choosing a blood pressure supplement, consider the ingredients, dosage, brand reputation, and cost.
Remember that supplements are not a substitute for a healthy lifestyle that includes a balanced diet, regular...
Source: The EMT Spot - May 3, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Supplements Source Type: blogs
Do Blood Pressure Supplements Interact With Any Foods Or Drinks?
Conclusion
To sum things up, blood pressure supplements are a safe and effective option for managing hypertension, and they typically do not interact with most foods and drinks.
However, some fruits and beverages may reduce the effectiveness of natural supplements. To ensure that you receive the maximum benefit from your blood pressure supplements, avoiding certain foods and drinks is essential.
Licorice, grapefruit, and alcohol are among the top culprits that can interfere with the efficacy of supplements and cause negative side effects.
High-fat meals and salt substitutes containing potassium can also hinder ...
Source: The EMT Spot - May 3, 2023 Category: Emergency Medicine Authors: Michael Rotman, MD, FRCPC, PhD Tags: Supplements Source Type: blogs
Bottlebrush Nanoparticles Deliver Immunostimulatory Drugs
Researchers at MIT have developed a nanoparticle system that is designed to deliver immunostimulatory drugs to tumors. These drugs are intended to stimulate immune cells in the vicinity of tumors to begin destroying tumor cells, but when delivered systemically they cause unacceptable dose limiting side-effects such as systemic inflammation. These particles are bottle-brush shaped, with the inactive drug being conjugated to the “brush backbone”. By tweaking the formulation of the particles, the researchers can fine tune their release profile, and have been able to create particles that will accumulate at the tumor witho...
Source: Medgadget - May 3, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine mit Source Type: blogs
