A Flawed Software Framing of Programmed Aging
The hypothesis that aging is a genetic program that is to some degree selected has always been a vocal minority view in the research community. There are just as many quite diverse theories of programmed aging as there are more mainstream evolutionary theories of aging that orbit the concept of antagonistic pleiotropy, the idea that lesser selection pressure in late life, because early reproduction means greater evolutionary fitness, allows for the evolution of mechanisms that are beneficial in youth and harmful in late life. There is even a fusion of the two sides: the hyperfunction theory of programmed aging suggests tha...
Source: Fight Aging! - April 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Consistency Quotes: 80 Powerful Sayings About the Most Underrated Success Habit
Few things are so powerful as taking consistent action and working towards your goal or dream each day.
It's the reliable but often forgotten or underrated motor that keeps you going until you get to where you want to go.
And without it you're likely to not get there at all. Or it will take a long, long time with many ups and down along the way.
With this post I'd like to inspire you to tap into this powerful habit more often. And I'd like to do that by sharing 80 of the best consistency quotes.
And if you want even more motivation for success then check out this post with quotes on how action speaks louder than words and...
Source: Practical Happiness and Awesomeness Advice That Works | The Positivity Blog - April 5, 2023 Category: Consumer Health News Authors: Henrik Edberg Tags: Inspirational Quotes Personal Development Source Type: blogs
Looking at the Connection Between Mitochondrial Dysfunction and Inflammation
Every cell contains hundreds of mitochondria, each with its own genome, mitochondrial DNA separate from that of the cell nucleus. The primary role of mitochondria is to generate chemical energy store molecules, adenosine triphosphate (ATP), used to power cell activities. Mitochondrial dysfunction with aging isn't just a loss of ATP generation and production of a harmful amount of reactive oxygen species, however. It can also be connected with chronic inflammation, as mislocalization of mitochondrial DNA can trigger sensors of the innate immune system to provide inflammatory signaling. Mitochondria are the descendants of an...
Source: Fight Aging! - April 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Gelatin-Based Surgical Sealant for Rapid Sealing Inside the Body
Researchers at the Terasaki Institute for Biomedical Innovation in Los Angeles have developed a gelatin-based surgical sealant. The sealant is thermoresponsive, meaning that it will rapidly form a semi-solid bolus when it reaches body temperature. It is also bioadhesive, adhering to slippery, wet surfaces in the body with relative ease. The researchers achieved this by incorporating caffeic acid, a substance that is naturally found in coffee and olive oil, into the gelatin gel, which helped to increase the adhesive strength of the formulation.
Sealing incisions within the body can be challenging. The slippe...
Source: Medgadget - April 3, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Surgery Source Type: blogs
Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cellular Senescence in Idiopathic Pulmonary Fibrosis
This review paper goes into some detail regarding present thought on the role of senescent cells of different types in idiopathic pulmonary fibrosis. Fibrosis in general is an often age-related dysfunction of normal tissue maintenance and regeneration, in which excessive extracellular matrix is created, leading to scar-like deposits that disrupt normal tissue structure and function. In the lung, this progressively impairs breathing and is ultimately fatal. Idiopathic pulmonary fibrosis was one of the first conditions for which early senolytic drugs to clear senescent cells were tested in humans.
Idiopathic pulmona...
Source: Fight Aging! - March 31, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
In Other Words: Not All Bases Are in the Ballpark
You might first think about sports when you hear the word base, but not all bases are on the baseball diamond. In chemistry, a base is a molecule that reacts with an acid, often by accepting a proton from the acid or from water. Baking soda and dish soap are common bases.
Credit: NIGMS.
A Building Block for Life
Bases are found throughout biological systems and in many molecules critical to life. The pH scale measures how acidic or basic (“alkaline”) liquids, such as water or blood, are. Liquids with a pH less than 7 are acidic, while liquids with a pH greater than 7 are basic. Electrolytes, like sodium, ca...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 29, 2023 Category: Research Authors: Chrissa Chverchko Tags: Cells Chemistry, Biochemistry and Pharmacology Molecular Structures DNA In Other Words RNA Source Type: blogs
ChemistGPT
There was lots of talk of ChatGPT apparently deciding to teach itself organic chemistry…now…ChatGPT is language model, it’s not really an artificial intelligence (AI) in the strict sense, all it really is is a sophisticated autocomplete that analyses your prompts and weighs up the most likely combination of words with which to reply. I wondered whether the only chemistry in all that hype was the chemistry between olfactory receptor and odourant molecules in bovine ordure. So, I set it a challenge, giving it the following prompt:
You are to act as an expert organic chemist. You need to devise a reaction sc...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 27, 2023 Category: Science Authors: David Bradley Tags: Artificial Intelligence Chemistry Source Type: blogs
Answer to Case 713
Answer to theParasite Case of the Week 713:Trichomonas vaginalistrophozoiteAs noted by Florida Fan, the Giemsa-stained preparation is ideal for highlighting the key morphologic features ofT. vaginalistrophozoites, including the flagella, undulating membrane, and axostyle. In my mind, the Pap stain just doesn ' t highlight the features as well. Here is an annotated image showing some of these features:The trophozoites ofT. vaginalisare 7-30 micrometers long, are tear drop/pear-shaped (i.e., pyriform), and have 5 flagella. Four flagella are anteriorly directed, while the 5th flagellum runs posteriorly along the undulat...
Source: Creepy Dreadful Wonderful Parasites - March 26, 2023 Category: Parasitology Source Type: blogs
CRISPR Combined with Glowing Proteins for Viral Detection
Researchers at Eindhoven University of Technology in the Netherlands have developed a sensitive diagnostic test for viral pathogens that is suitable for use in low-resource regions. The test is based on CRISPR proteins that can detect viral genetic material but also incorporates luciferase proteins, which are bioluminescent proteins that are naturally found in fireflies and other creatures. Two CRISPR/Cas proteins are specific for different parts of the viral genome, and when they both bind to target nucleic acid sequences they join together, uniting two fragments of luciferase and initiating a bioluminescent signal. The r...
Source: Medgadget - March 23, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Genetics Medicine Public Health CRISPR TUeindhoven Source Type: blogs
Automating Cellular Image Analysis to Find Potential Medicines
Dr. Anne Carpenter. Credit: Juliana Sohn.
When she started college, Anne Carpenter, Ph.D., never guessed she’d one day create software for analyzing images of cells that would help identify potential medicines and that thousands of researchers would use. She wasn’t planning to become a computational biologist, or even to focus on science at all, but she’s now an institute scientist and the senior director of the Imaging Platform at the Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard in Cambridge.
Starting Out in Science
Before beginning her undergraduate studies at Purdue University...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 22, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Cells Tools and Techniques Bioinformatics Cellular Imaging Computational Biology Cool Tools/Techniques Profiles Source Type: blogs
Scientists Grow Electrodes Inside The Body
Researchers at Linköping University in Sweden have developed a method whereby the body can ‘grow its own’ electrodes. The minimally invasive technique involves injecting a hydrogel that is laden with enzymes into target tissues. The enzymes interact with molecules that are present in the tissue to change the structure of the gel and allow it to become electrically conductive. The approach could facilitate a variety of advanced medical systems, from pacemakers to brain-computer interfaces. Excitingly, the technology avoids the need for invasive surgery or conventional stiff electrical components that are not well match...
Source: Medgadget - March 17, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Cardiac Surgery Cardiology Materials Neurology Neurosurgery bci bci brain computer interface Source Type: blogs
A foreboding of petrels
I have just finished reading the latest novel in Steve Burrows’ series of “birder murder” stories. This one was called A Foreboding of Petrels and hinges on apparently unconnected murders on the North Norfolk coast and at an environmental research station in The Antarctic.
The plot of the novel alludes to the Storm Petrel, perhaps the world’s most abundant avian species. It and related species have an incredibly sensitive sense of smell and can detect keystone odourant molecules on the wind. Compounds such as dimethyl sulfide (DMS) are released into atmosphere when other organisms are feasting on a...
Source: David Bradley Sciencebase - Songs, Snaps, Science - March 14, 2023 Category: Science Authors: David Bradley Tags: Birds Environment Source Type: blogs
Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Funding Opportunity: Modules for Enhancing Biomedical Research Workforce Training
We’re pleased to announce a new notice of special interest (NOSI) (NOT-GM-23-031) associated with PAR-20-296, modules for enhancing biomedical research workforce training (R25). The NOSI requests applications to develop biomedical research training modules on one of the following topics:
Wellness and resiliency: effectively providing individuals with the knowledge and skills to enhance their wellness, resiliency, and ultimate success during their research training.
Structural racism and discrimination: addressing harassment, intimidation, and other forms of structural racism and discrimination to reduce dispa...
Source: NIGMS Feedback Loop Blog - National Institute of General Medical Sciences - March 10, 2023 Category: Biomedical Science Authors: Chrissa Chverchko Tags: Funding Opportunities Resources Training/Fellowships/Career Development Research Resources Source Type: blogs
